Daniel B. Owen
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View article: Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging
Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging Open
Cognitive function in aging is heterogeneous: while some older individuals develop significant impairments and dementia, others remain resilient and retain cognitive function throughout their lifespan. The molecular mechanisms that underli…
View article: The Ability of Activity and Cognition in Old Mice to Predict Age of Death
The Ability of Activity and Cognition in Old Mice to Predict Age of Death Open
The goal of this study was to determine if measures of healthspan, which have been shown to decline with age, are associated with and predict mortality. We measured voluntary running activity, spontaneous activity, and cognition in male an…
View article: Neuronal Necroptosis Drives Neuroinflammation and Cognitive Decline Independent of Neuronal Cell Death
Neuronal Necroptosis Drives Neuroinflammation and Cognitive Decline Independent of Neuronal Cell Death Open
Markers of necroptosis increase in neurons with neurodegenerative diseases and aging. Using a novel knockin mouse model that overexpresses the terminal necroptosis effector gene MLKL specifically in neurons (nMlkl-KI), we studied the impac…
View article: Mitochondrial calcium uniporter deficiency in dentate granule cells remodels neuronal metabolism and impairs reversal learning
Mitochondrial calcium uniporter deficiency in dentate granule cells remodels neuronal metabolism and impairs reversal learning Open
The mitochondrial calcium uniporter (MCU) is the main route of calcium (Ca 2+ ) entry into neuronal mitochondria. This channel has been linked to mitochondrial Ca 2+ overload and cell death under neurotoxic conditions, but its physiologic …
View article: Progressive cognitive impairment after recovery from neuroinvasive and non-neuroinvasive Listeria monocytogenes infection
Progressive cognitive impairment after recovery from neuroinvasive and non-neuroinvasive Listeria monocytogenes infection Open
Background Neuro-cognitive impairment is a deleterious complication of bacterial infections that is difficult to treat or prevent. Listeria monocytogenes ( Lm ) is a neuroinvasive bacterial pathogen and commonly used model organism for stu…
View article: Cognitive heterogeneity reveals molecular signatures of age-related impairment
Cognitive heterogeneity reveals molecular signatures of age-related impairment Open
The greatest risk factor for cognitive decline is aging. The biological mechanisms for this decline remain enigmatic due, in part, to the confounding of normal aging mechanisms and those that contribute to cognitive impairment. Importantly…
View article: Selective Ablation of <i>Sod2</i> in Astrocytes Induces Sex-Specific Effects on Cognitive Function, d-Serine Availability, and Astrogliosis
Selective Ablation of <i>Sod2</i> in Astrocytes Induces Sex-Specific Effects on Cognitive Function, d-Serine Availability, and Astrogliosis Open
Cognitive decline is a debilitating aspect of aging and neurodegenerative diseases such as Alzheimer's disease are closely associated with mitochondrial dysfunction, increased reactive oxygen species, neuroinflammation, and astrogliosis. T…
View article: Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice
Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice Open
Cognitive decline with age is a harmful process that can reduce quality of life. Multiple factors have been established to contribute to cognitive decline, but the overall etiology remains unknown. Here, we hypothesized that cognitive dysf…
View article: Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function
Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function Open
Age-related decline in circulating levels of insulin-like growth factor (IGF)-1 is associated with reduced cognitive function, neuronal aging, and neurodegeneration. Decreased mitochondrial function along with increased reactive oxygen spe…
View article: Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes
Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes Open
Regulation of astrocytic mitochondrial function and redox status by IGF-1 is essential to maintain astrocytic function and coordinate hippocampal-dependent spatial learning. Age-related astrocytic dysfunction caused by diminished IGF-1 sig…