Daniel B. Polley
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View article: The slowest timescales of neural synchronization reveal the strongest influence of auditory distraction
The slowest timescales of neural synchronization reveal the strongest influence of auditory distraction Open
Introduction Among all the sounds occurring at any given time, people are often interested in listening to just one. Some competing sounds are merely background noise, whereas others distract attention from target sounds and are less easil…
View article: Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex
Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex Open
Basal forebrain cholinergic neurons (BFCNs) densely innervate auditory cortex (ACtx), conveying signals linked to internal brain states and external sensory cues. Several studies have shown that acetylcholine (ACh) rapidly modifies local c…
View article: Arousal state fluctuations are a source of internal noise underlying age-related declines in speech intelligibility
Arousal state fluctuations are a source of internal noise underlying age-related declines in speech intelligibility Open
Understanding speech in noisy, multi-talker environments is crucial for social communication but becomes increasingly challenging and frustrating as we age. Here, we simulated the acoustic challenges of multi-talker listening and found tha…
View article: The Slowest Timescales of Neural Synchronization Reveal the Strongest Influence of Auditory Distraction
The Slowest Timescales of Neural Synchronization Reveal the Strongest Influence of Auditory Distraction Open
Among all the sounds occurring at any given time, people are often interested in listening to just one. Some competing sounds are merely background noise, whereas others distract attention from target sounds and are less easily suppressed.…
View article: Objective autonomic signatures of tinnitus and sound sensitivity disorders
Objective autonomic signatures of tinnitus and sound sensitivity disorders Open
Hypersensitivity, phantom percepts, and sensory reactivity are core features of many neurological disorders. Direct, objective measurements of these features have proven difficult to identify, leaving subjective questionnaires as the prima…
View article: Cortical determinants of loudness perception and auditory hypersensitivity
Cortical determinants of loudness perception and auditory hypersensitivity Open
Summary Parvalbumin-expressing inhibitory neurons (PVNs) stabilize cortical network activity, generate gamma rhythms, and regulate experience-dependent plasticity. Here, we observed that activation or inactivation of PVNs functioned like a…
View article: Reward contingency gates selective cholinergic suppression of amygdala neurons
Reward contingency gates selective cholinergic suppression of amygdala neurons Open
Basal forebrain cholinergic neurons modulate how organisms process and respond to environmental stimuli through impacts on arousal, attention, and memory. It is unknown, however, whether basal forebrain cholinergic neurons are directly inv…
View article: The human pupil and face encode sound affect and provide objective signatures of tinnitus and auditory hypersensitivity disorders
The human pupil and face encode sound affect and provide objective signatures of tinnitus and auditory hypersensitivity disorders Open
Summary Sound is jointly processed along acoustic and emotional dimensions. These dimensions can become distorted and entangled in persons with sensory disorders, producing a spectrum of loudness hypersensitivity, phantom percepts, and – i…
View article: Sound elicits stereotyped facial movements that provide a sensitive index of hearing abilities
Sound elicits stereotyped facial movements that provide a sensitive index of hearing abilities Open
SUMMARY Sound elicits rapid movements of muscles in the face, ears, and eyes that protect the body from injury and trigger brain-wide internal state changes. Here, we performed quantitative facial videography from mice resting atop a piezo…
View article: Sensory representations and pupil-indexed listening effort provide complementary contributions to multi-talker speech intelligibility
Sensory representations and pupil-indexed listening effort provide complementary contributions to multi-talker speech intelligibility Open
Optimal speech perception in noise requires successful separation of the target speech stream from multiple competing background speech streams. The ability to segregate these competing speech streams depends on the fidelity of bottom-up n…
View article: Reward contingency gates selective cholinergic suppression of amygdala neurons
Reward contingency gates selective cholinergic suppression of amygdala neurons Open
Basal forebrain cholinergic neurons modulate how organisms process and respond to environmental stimuli through impacts on arousal, attention, and memory. It is unknown, however, whether basal forebrain cholinergic neurons are directly inv…
View article: Reward contingency gates selective cholinergic suppression of amygdala neurons
Reward contingency gates selective cholinergic suppression of amygdala neurons Open
Basal forebrain cholinergic neurons modulate how organisms process and respond to environmental stimuli through impacts on arousal, attention, and memory. It is unknown, however, whether basal forebrain cholinergic neurons are directly inv…
View article: Cortical contributions to the perception of loudness and hyperacusis
Cortical contributions to the perception of loudness and hyperacusis Open
Sound perception is closely linked to the spatiotemporal patterning of neural activity in the auditory cortex (ACtx). Inhibitory interneurons sculpt the patterns of excitatory ACtx pyramidal neuron activity, and thus play a central role in…
View article: Potentiated cholinergic and corticofugal inputs support reorganized sensory processing in the basolateral amygdala during auditory threat acquisition and retrieval
Potentiated cholinergic and corticofugal inputs support reorganized sensory processing in the basolateral amygdala during auditory threat acquisition and retrieval Open
Summary Reappraising neutral stimuli as environmental threats reflects rapid and discriminative changes in sensory processing within the basolateral amygdala (BLA). To understand how BLA inputs are also reorganized during discriminative th…
View article: Neural signatures of auditory hypersensitivity following acoustic trauma
Neural signatures of auditory hypersensitivity following acoustic trauma Open
Neurons in sensory cortex exhibit a remarkable capacity to maintain stable firing rates despite large fluctuations in afferent activity levels. However, sudden peripheral deafferentation in adulthood can trigger an excessive, non-homeostat…
View article: Author response: Neural signatures of auditory hypersensitivity following acoustic trauma
Author response: Neural signatures of auditory hypersensitivity following acoustic trauma Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Neurons in sensory cor…
View article: Automatic identification of tinnitus malingering based on overt and covert behavioral responses during psychoacoustic testing
Automatic identification of tinnitus malingering based on overt and covert behavioral responses during psychoacoustic testing Open
Tinnitus, or ringing in the ears, is a prevalent condition that imposes a substantial health and financial burden on the patient and to society. The diagnosis of tinnitus, like pain, relies on patient self-report, which can complicate the …
View article: Predicting neural deficits in sensorineural hearing loss from word recognition scores
Predicting neural deficits in sensorineural hearing loss from word recognition scores Open
The current gold standard of clinical hearing assessment includes a pure-tone audiogram combined with a word recognition task. This retrospective study tests the hypothesis that deficits in word recognition that cannot be explained by loss…
View article: Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms
Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms Open
In animal models, cochlear neural degeneration (CND) is associated with excess central gain and hyperacusis, but a compelling link between reduced cochlear neural inputs and heightened loudness perception in humans remains elusive. The pre…
View article: Neural signatures of auditory hypersensitivity following acoustic trauma
Neural signatures of auditory hypersensitivity following acoustic trauma Open
Throughout the brain, neurons exhibit a remarkable capacity to maintain stable firing rates despite large perturbations in afferent activity levels. As an exception, homeostatic regulation of neural activity often fails in the adult audito…
View article: Reward contingency gates selective cholinergic suppression of amygdala neurons
Reward contingency gates selective cholinergic suppression of amygdala neurons Open
Basal forebrain cholinergic neurons modulate how organisms process and respond to environmental stimuli through impacts on arousal, attention, and memory. It is unknown, however, whether basal forebrain cholinergic neurons are directly inv…
View article: Automatic Identification of Tinnitus Malingering Based on Overt and Covert Behavioral Responses During Psychoacoustic Testing
Automatic Identification of Tinnitus Malingering Based on Overt and Covert Behavioral Responses During Psychoacoustic Testing Open
Tinnitus, or ringing in the ears, is a prevalent condition that imposes a substantial health and financial burden on the patient and to society. The diagnosis of tinnitus, like pain, relies on patient self-report. Subjective self-report me…
View article: Author response: A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes
Author response: A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Basal forebrain cholin…
View article: Behavioral Approaches to Study Top-Down Influences on Active Listening
Behavioral Approaches to Study Top-Down Influences on Active Listening Open
The massive network of descending corticofugal projections has been long-recognized by anatomists, but their functional contributions to sound processing and auditory-guided behaviors remain a mystery. Most efforts to characterize the audi…
View article: A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes
A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes Open
Basal forebrain cholinergic neurons (BFCNs) project throughout the cortex to regulate arousal, stimulus salience, plasticity, and learning. Although often treated as a monolithic structure, the basal forebrain features distinct connectivit…