Daniel Batlle
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View article: Aminopeptidase A Effect on Angiotensin Peptides and Their Blood Pressure Action
Aminopeptidase A Effect on Angiotensin Peptides and Their Blood Pressure Action Open
Aminopeptidase A (APA) cleaves a single aspartate residue from the amino terminus of peptides within the renin angiotensin system (RAS). Since several RAS peptides contain an N-terminal aspartate, we developed an assay to evaluate the effe…
View article: ACE2, From the Kidney to SARS-CoV-2: Donald Seldin Award Lecture 2023
ACE2, From the Kidney to SARS-CoV-2: Donald Seldin Award Lecture 2023 Open
ACE2 (angiotensin-converting enzyme 2) is a monocarboxypeptidase that cleaves Ang II (angiotensin II) among other substrates. ACE2 is present in the cell membrane of many organs, most abundantly in epithelial cells of kidney proximal tubul…
View article: Long-Circulating Vasoactive 1,18-Octadecanedioic Acid–Terlipressin Conjugate
Long-Circulating Vasoactive 1,18-Octadecanedioic Acid–Terlipressin Conjugate Open
Hepatorenal syndrome (HRS) is a life-threatening complication of end-stage liver disease first reported over a century ago, but its management still poses an unmet challenge. A therapeutic agent found to stabilize the condition is a short …
View article: Effect of SARS-CoV-2 S protein on the proteolytic cleavage of the epithelial Na+ channel ENaC
Effect of SARS-CoV-2 S protein on the proteolytic cleavage of the epithelial Na+ channel ENaC Open
Severe cases of COVID-19 are characterized by development of acute respiratory distress syndrome (ARDS). Water accumulation in the lungs is thought to occur as consequence of an exaggerated inflammatory response. A possible mechanism could…
View article: Sodium Zirconium Cyclosilicate in CKD, Hyperkalemia, and Metabolic Acidosis
Sodium Zirconium Cyclosilicate in CKD, Hyperkalemia, and Metabolic Acidosis Open
Key Points Sodium zirconium cyclosilicate effectively lowers serum potassium and maintains normokalemia in patients with CKD with concomitant hyperkalemia and metabolic acidosis. Despite high screen failure and small sample size, a nominal…
View article: Soluble Angiotensin-Converting Enzyme 2 Protein Improves Survival and Lowers Viral Titers in Lethal Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection with the Delta Variant
Soluble Angiotensin-Converting Enzyme 2 Protein Improves Survival and Lowers Viral Titers in Lethal Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection with the Delta Variant Open
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) utilizes angiotensin-converting enzyme 2 (ACE2) as its main receptor for cell entry. We bioengineered a soluble ACE2 protein termed ACE2 618-DDC-ABD that has increased bindi…
View article: A Soluble ACE2 Protein Improves Survival and Lowers Viral Titers in a Lethal Mouse Model of SARS-CoV-2 Infection with the Delta Variant
A Soluble ACE2 Protein Improves Survival and Lowers Viral Titers in a Lethal Mouse Model of SARS-CoV-2 Infection with the Delta Variant Open
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) utilizes Angiotensin Converting Enzyme 2 (ACE2) as its main receptor for cell entry. We have bioengineered a soluble ACE2 protein termed ACE2 618-DDC-ABD that has increased …
View article: #5797 AMINOPEPTIDASE A REGULATES ACUTE ANGIOTENSIN DEPENDENT HYPERTENSION
#5797 AMINOPEPTIDASE A REGULATES ACUTE ANGIOTENSIN DEPENDENT HYPERTENSION Open
Background and Aims Aminopeptidase A (APA) is an enzyme that cleaves a single aspartate residue from the amino-terminus of several renin-angiotensin systems (RAS) peptides. We have shown that genetic deficiency of APA was associated with i…
View article: FSGS and COVID-19 in Non–African American Patients
FSGS and COVID-19 in Non–African American Patients Open
Collapsing Focal Segmental Glomerulosclerosis (FSGS) has been reported relatively frequently in African American (AA) patients with coronavirus disease 2019 (COVID-19), and it is associated almost always with Apolipoprotein L gen 1 ( APOL1…
View article: Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection
Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection Open
A soluble ACE2 protein bioengineered for long duration of action and high affinity to SARS-CoV-2 was administered either intranasally (IN) or intraperitoneally (IP) to SARS-CoV-2–inoculated k18hACE2 mice. This decoy protein (ACE2 618-DDC-A…
View article: An Update on Kidney Ammonium Transport Along the Nephron
An Update on Kidney Ammonium Transport Along the Nephron Open
Acid-base homeostasis is critical to the maintenance of normal health. The kidneys have a central role in bicarbonate generation, which occurs through the process of net acid excretion. Renal ammonia excretion is the predominant component …
View article: Superiority of intranasal over systemic administration of bioengineered soluble ACE2 for survival and brain protection against SARS-CoV-2 infection
Superiority of intranasal over systemic administration of bioengineered soluble ACE2 for survival and brain protection against SARS-CoV-2 infection Open
The present study was designed to investigate the effects of a soluble ACE2 protein termed ACE2 618-DDC-ABD, bioengineered to have long duration of action and high binding affinity to SARS-CoV-2, when administered either intranasally (IN) …
View article: ACE2 in the Urine: Where Does It Come From?
ACE2 in the Urine: Where Does It Come From? Open
Introduction An enzyme that metabolizes angiotensin II (Ang II) and other substrates was discovered in 2000, and was termed angiotensin converting enzyme 2 (ACE2) because of its substantial homology with ACE. Since the beginning of the cor…
View article: On the essentiality of the angiotensin converting enzyme 2 receptor for SARS‐CoV‐2 infection and the potential of soluble angiotensin converting enzyme 2 proteins as universal approach for variants causing COVID‐19
On the essentiality of the angiotensin converting enzyme 2 receptor for SARS‐CoV‐2 infection and the potential of soluble angiotensin converting enzyme 2 proteins as universal approach for variants causing COVID‐19 Open
After the outbreak of severe actute respiratory syndrom coronavirus (SARS-CoV) in 2003, it was shown that angiotensin converting enzyme 2 (ACE2) was the receptor for this coronavrius.1 As early as January 2020, it was reported that ACE2 wa…
View article: Serum potassium changes during hypothermia and rewarming: a case series and hypothesis on the mechanism
Serum potassium changes during hypothermia and rewarming: a case series and hypothesis on the mechanism Open
Introduction Hypokalemia is known to occur in association with therapeutically induced hypothermia and is usually managed by the administration of potassium (K+). Methods We reviewed data from 74 patients who underwent a therapeutic hypoth…
View article: Spherical nucleic acids as an infectious disease vaccine platform
Spherical nucleic acids as an infectious disease vaccine platform Open
Significance Using SARS-CoV-2 as a relevant case study for infectious disease, we investigate the structure–function relationships that dictate antiviral spherical nucleic acid (SNA) vaccine efficacy. We show that the SNA architecture can …
View article: A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection
A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection Open
Background Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) uses full-length angiotensin converting enzyme 2 (ACE2) as a main receptor to enter target cells. The goal of this study was to demonstrate the preclinical effica…
View article: Effect of Sodium Zirconium Cyclosilicate on Serum Potassium and Bicarbonate in Patients with Hyperkalemia and Metabolic Acidosis Associated with Chronic Kidney Disease: Rationale and Design of the NEUTRALIZE Study
Effect of Sodium Zirconium Cyclosilicate on Serum Potassium and Bicarbonate in Patients with Hyperkalemia and Metabolic Acidosis Associated with Chronic Kidney Disease: Rationale and Design of the NEUTRALIZE Study Open
Introduction: Sodium zirconium cyclosilicate (SZC) is a selective potassium (K+) binder for hyperkalemia management that provides rapid and sustained correction of hyperkalemia. The NEUTRALIZE study is investigating whether SZC, in additio…
View article: Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19
Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19 Open
Despite evidence of multiorgan tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with coronavirus disease 2019 (COVID-19), direct viral kidney invasion has been difficult to demonstrate. The question of wh…