Daniel Béchet
YOU?
Author Swipe
View article: A Single Bout of Ultra-Endurance Exercise Reveals Early Signs of Muscle Aging in Master Athletes
A Single Bout of Ultra-Endurance Exercise Reveals Early Signs of Muscle Aging in Master Athletes Open
Middle-aged and master endurance athletes exhibit similar physical performance and long-term muscle adaptation to aerobic exercise. Nevertheless, we hypothesized that the short-term plasticity of the skeletal muscle might be distinctly alt…
View article: Magnesium Homeostasis in Myogenic Differentiation—A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters
Magnesium Homeostasis in Myogenic Differentiation—A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters Open
Magnesium (Mg) is essential for skeletal muscle health, but little is known about the modulation of Mg and its transporters in myogenic differentiation. Here, we show in C2C12 murine myoblasts that Mg concentration fluctuates during their …
View article: A Mix of Dietary Fibres Changes Interorgan Nutrients Exchanges and Muscle-Adipose Energy Handling in Overfed Mini-Pigs
A Mix of Dietary Fibres Changes Interorgan Nutrients Exchanges and Muscle-Adipose Energy Handling in Overfed Mini-Pigs Open
This study evaluates the capacity of a bread enriched with fermentable dietary fibres to modulate the metabolism and nutrients handling between tissues, gut and peripheral, in a context of overfeeding. Net fluxes of glucose, lactate, urea,…
View article: UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin
UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin Open
The ubiquitin proteasome system (UPS) is the main player of skeletal muscle wasting, a common characteristic of many diseases (cancer, etc.) that negatively impacts treatment and life prognosis. Within the UPS, the E3 ligase MuRF1/TRIM63 t…
View article: Concurrent BMP Signaling Maintenance and TGF-β Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear
Concurrent BMP Signaling Maintenance and TGF-β Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear Open
Muscle atrophy arises from a multiplicity of physio-pathological situations and has very detrimental consequences for the whole body. Although knowledge of muscle atrophy mechanisms keeps growing, there is still no proven treatment to date…
View article: Magnesium Deficiency Alters Expression of Genes Critical for Muscle Magnesium Homeostasis and Physiology in Mice
Magnesium Deficiency Alters Expression of Genes Critical for Muscle Magnesium Homeostasis and Physiology in Mice Open
Chronic Mg2+ deficiency is the underlying cause of a broad range of health dysfunctions. As 25% of body Mg2+ is located in the skeletal muscle, Mg2+ transport and homeostasis systems (MgTHs) in the muscle are critical for whole-body Mg2+ h…
View article: Muscle Proteomic and Transcriptomic Profiling of Healthy Aging and Metabolic Syndrome in Men
Muscle Proteomic and Transcriptomic Profiling of Healthy Aging and Metabolic Syndrome in Men Open
(1) Background: Aging is associated with a progressive decline in muscle mass and function. Aging is also a primary risk factor for metabolic syndrome, which further alters muscle metabolism. However, the molecular mechanisms involved rema…
View article: Magnesium Influences Membrane Fusion during Myogenesis by Modulating Oxidative Stress in C2C12 Myoblasts
Magnesium Influences Membrane Fusion during Myogenesis by Modulating Oxidative Stress in C2C12 Myoblasts Open
Magnesium (Mg) is essential to skeletal muscle where it plays a key role in myofiber relaxation. Although the importance of Mg in the mature skeletal muscle is well established, little is known about the role of Mg in myogenesis. We studie…
View article: Mitophagy and Mitochondria Biogenesis Are Differentially Induced in Rat Skeletal Muscles during Immobilization and/or Remobilization
Mitophagy and Mitochondria Biogenesis Are Differentially Induced in Rat Skeletal Muscles during Immobilization and/or Remobilization Open
Mitochondria alterations are a classical feature of muscle immobilization, and autophagy is required for the elimination of deficient mitochondria (mitophagy) and the maintenance of muscle mass. We focused on the regulation of mitochondria…
View article: Beneficial effects of endurance exercise training on skeletal muscle microvasculature in sickle cell disease patients
Beneficial effects of endurance exercise training on skeletal muscle microvasculature in sickle cell disease patients Open
In a Plenary Paper, Merlet et al report a provocative and elegant study demonstrating that exercise training leads to muscle capillary growth in patients with sickle cell disease, a finding with potential to improve their lives.
View article: Muscle wasting in patients with end‐stage renal disease or early‐stage lung cancer: common mechanisms at work
Muscle wasting in patients with end‐stage renal disease or early‐stage lung cancer: common mechanisms at work Open
Background Loss of muscle mass worsens many diseases such as cancer and renal failure, contributes to the frailty syndrome, and is associated with an increased risk of death. Studies conducted on animal models have revealed the preponderan…
View article: Erratum: Polge, C., et al. UBE2E1 Is Preferentially Expressed in the Cytoplasm of Slow-Twitch Fibers and Protects Skeletal Muscles from Exacerbated Atrophy upon Dexamethasone Treatment. Cells 2018, 7, 214
Erratum: Polge, C., et al. UBE2E1 Is Preferentially Expressed in the Cytoplasm of Slow-Twitch Fibers and Protects Skeletal Muscles from Exacerbated Atrophy upon Dexamethasone Treatment. Cells 2018, 7, 214 Open
Change in author names (order). [...]
View article: UBE2E1 Is Preferentially Expressed in the Cytoplasm of Slow-Twitch Fibers and Protects Skeletal Muscles from Exacerbated Atrophy upon Dexamethasone Treatment
UBE2E1 Is Preferentially Expressed in the Cytoplasm of Slow-Twitch Fibers and Protects Skeletal Muscles from Exacerbated Atrophy upon Dexamethasone Treatment Open
Skeletal muscle mass is reduced during many diseases or physiological situations (disuse, aging), which results in decreased strength and increased mortality. Muscle mass is mainly controlled by the ubiquitin-proteasome system (UPS), invol…
View article: Increased Serpina3n release into circulation during glucocorticoid‐mediated muscle atrophy
Increased Serpina3n release into circulation during glucocorticoid‐mediated muscle atrophy Open
Background Glucocorticoids (GC) play a major role in muscle atrophy. As skeletal muscle is a secretory organ, characterization of the muscle secretome elicited by muscle atrophy should allow to better understand the cellular mechanisms and…
View article: Cellular and functional mechanisms underlying muscle aging and associated diseases
Cellular and functional mechanisms underlying muscle aging and associated diseases Open
The loss of skeletal muscle mass and function during the aging process (sarcopenia) has a major impact on muscle function and is a key component of frailty. A clear understanding of the mechanisms of sarcopenia through the identification o…
View article: A muscle-specific MuRF1-E2 Network requires stabilization of MuRF1-E2 complexes by Telethonin, a newly identified substrate
A muscle-specific MuRF1-E2 Network requires stabilization of MuRF1-E2 complexes by Telethonin, a newly identified substrate Open
Muscle wasting is observed during the development of many diseases and also during non-pathological situations (disuse, aging). Skeletal muscle mass is largely controlled by the ubiquitin-proteasome system and thus by ubiquitinating enzyme…
View article: A muscle‐specific <scp>MuRF1‐E2</scp> network requires stabilization of <scp>MuRF1‐E2</scp> complexes by telethonin, a newly identified substrate
A muscle‐specific <span>MuRF1‐E2</span> network requires stabilization of <span>MuRF1‐E2</span> complexes by telethonin, a newly identified substrate Open
Background Muscle wasting is observed in the course of many diseases and also during physiological conditions (disuse, ageing). Skeletal muscle mass is largely controlled by the ubiquitin‐proteasome system and thus by the ubiquitinating en…
View article: Abstracts of the 9<sup>th</sup> International Conference on Cachexia, Sarcopenia and Muscle Wasting, Berlin, Germany, 10–11 December 2016 (part 1)
Abstracts of the 9<sup>th</sup> International Conference on Cachexia, Sarcopenia and Muscle Wasting, Berlin, Germany, 10–11 December 2016 (part 1) Open
Background and aims: Cachexia and muscle atrophy are common derivations of cancer and chemotherapy treatments (cisplatin). Growth Hormone Secretagogues (GHSs) are synthetic peptidic and nonpeptidic molecules, able to stimulate Growth Hormo…
View article: A Proof of Concept to Bridge the Gap between Mass Spectrometry Imaging, Protein Identification and Relative Quantitation: MSI~LC-MS/MS-LF
A Proof of Concept to Bridge the Gap between Mass Spectrometry Imaging, Protein Identification and Relative Quantitation: MSI~LC-MS/MS-LF Open
Mass spectrometry imaging (MSI) is a powerful tool to visualize the spatial distribution of molecules on a tissue section. The main limitation of MALDI-MSI of proteins is the lack of direct identification. Therefore, this study focuses on …
View article: Upregulation of MuRF1 and MAFbx participates to muscle wasting upon gentamicin-induced Acute Renal Failure
Upregulation of MuRF1 and MAFbx participates to muscle wasting upon gentamicin-induced Acute Renal Failure Open
Acute Renal Failure (ARF) is frequently encountered in hospitalized patients where it is associated with increased mortality and morbidity notably affecting muscle wasting. Increased protein degradation has been shown to be the main factor…
View article: Mechanisms of myofibrillar proteolysis in skeletal muscle: role of E2 enzymes
Mechanisms of myofibrillar proteolysis in skeletal muscle: role of E2 enzymes Open
ORGANIZING COMMITTEE Chairs: Didier Attaix - Lydie Combaret - Daniel Taillandier Daniel Béchet - Agnès Claustre - Cécile Coudy-Gandilhon - Christiane Deval - Gérard Donadille - Cécile Polge SCIENTIFIC COMMITTEE Didier Attaix - Lydie Combar…
View article: The coordinated up-regulation of the ubiquitin-proteasome and autophagy-lysosomal pathways strongly alters the Human muscle proteome during ultra-endurance exercise
The coordinated up-regulation of the ubiquitin-proteasome and autophagy-lysosomal pathways strongly alters the Human muscle proteome during ultra-endurance exercise Open
ORGANIZING COMMITTEE Chairs: Didier Attaix - Lydie Combaret - Daniel Taillandier Daniel Béchet - Agnès Claustre - Cécile Coudy-Gandilhon - Christiane Deval - Gérard Donadille - Cécile Polge SCIENTIFIC COMMITTEE Didier Attaix - Lydie Combar…
View article: Docosahexaenoic acid‐supplementation prior to fasting prevents muscle atrophy in mice
Docosahexaenoic acid‐supplementation prior to fasting prevents muscle atrophy in mice Open
Background Muscle wasting prevails in numerous diseases (e.g. diabetes, cardiovascular and kidney diseases, COPD,…) and increases healthcare costs. A major clinical issue is to devise new strategies preventing muscle wasting. We hypothesiz…