David Beckett
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View article: Adaptations in <i>Plasmodium</i> tubulin determine unique microtubule architectures, mechanics and drug susceptibility
Adaptations in <i>Plasmodium</i> tubulin determine unique microtubule architectures, mechanics and drug susceptibility Open
Microtubules are ubiquitous yet diverse cytoskeleton filaments. However, tubulin conservation presents challenges in understanding the origins of diverse microtubule architectures. The mechanisms by which microtubule architecture varies th…
View article: An mTOR Inhibitor Discovery System Using the Growth of Drug-Sensitized Yeast Strains
An mTOR Inhibitor Discovery System Using the Growth of Drug-Sensitized Yeast Strains Open
Inhibition of the target of rapamycin (TOR/mTOR) protein kinase by the drug rapamycin extends lifespan and healthspan across diverse species. However, rapamycin has potential off-target and side effects that warrant the discovery of additi…
View article: Clarivein® might have a role in the treatment of truncal pelvic vein reflux, but not in the treatment of pelvic varicosities - results from an ovine model.
Clarivein® might have a role in the treatment of truncal pelvic vein reflux, but not in the treatment of pelvic varicosities - results from an ovine model. Open
Aims:Pelvic vein embolisation is the recognised treatment for symptomatic pelvic vein reflux. There is a requirement to ablate incompetent pelvic veins without using an implantable device. The aim of this study was to assess the use of the…
View article: 324 Outcomes of Prostate Artery Embolisation In Catheterised Patients: A Case Series
324 Outcomes of Prostate Artery Embolisation In Catheterised Patients: A Case Series Open
Aim Prostate artery embolisation (PAE) is an approved treatment for men with lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH-LUTS). Evidence of efficacy for PAE in patients who are unable to void urine spontaneo…
View article: Six-Month Results of Treatment-Blinded Medication Titration for Hypertension Control After Randomization to Endovascular Ultrasound Renal Denervation or a Sham Procedure in the RADIANCE-HTN SOLO Trial
Six-Month Results of Treatment-Blinded Medication Titration for Hypertension Control After Randomization to Endovascular Ultrasound Renal Denervation or a Sham Procedure in the RADIANCE-HTN SOLO Trial Open
Background: The multicenter, international, randomized, blinded, sham-controlled RADIANCE-HTN SOLO trial (A Study of the ReCor Medical Paradise System in Clinical Hypertension) demonstrated a 6.3 mm Hg greater reduction in daytime ambulato…
View article: Anatomical Abnormalities of the Pelvic Venous System and their Implications for Endovascular Management of Pelvic Venous Reflux
Anatomical Abnormalities of the Pelvic Venous System and their Implications for Endovascular Management of Pelvic Venous Reflux Open
Background: Pelvic venous reflux is often treated with pelvic vein embolisation; however, atypical pelvic venous anatomy may provide therapeutic challenges. Method(s): We retrospectively over 100 patient files and reported symptoms and dia…
View article: Pelvic Venous Reflux in Males with Varicose Veins and Recurrent Varicose Veins
Pelvic Venous Reflux in Males with Varicose Veins and Recurrent Varicose Veins Open
Background: To report on a male cohort with pelvic vein reflux and associated primary and recurrent lower limb varicose veins. Method(s): Full lower limb duplex ultrasonography revealed significant pelvic contribution in eight males (3% of…
View article: Pelvic Vein Embolisation of Gonadal and Internal Iliac Veins Can be Performed Safely and with Good Technical Results in an Ambulatory Vein Clinic, Under Local Anaesthetic Alone: Results from Two Years’ Experience
Pelvic Vein Embolisation of Gonadal and Internal Iliac Veins Can be Performed Safely and with Good Technical Results in an Ambulatory Vein Clinic, Under Local Anaesthetic Alone: Results from Two Years’ Experience Open
Background: Pelvic vein embolisation is increasing in venous practice for the treatment of conditions associated with pelvic venous reflux. In July 2014, we introduced a local anaesthetic “walk-in walk-out” pelvic vein embolisation service…
View article: Does Left Ovarian Vein Reflux Cause a Pseudo-Nutcracker Effect Creating Meso-Aortic Narrowing of the Left Renal Vein?
Does Left Ovarian Vein Reflux Cause a Pseudo-Nutcracker Effect Creating Meso-Aortic Narrowing of the Left Renal Vein? Open
Background: Trans-abdominal and trans-vaginal ultrasounds are performed for pelvic venous reflux. Patients are scanned at diagnosis and at 6-8 weeks following Pelvic Vein Embolization. Our aim was: 1) Identify the proximal extent of Left O…
View article: Diagnosis of stenosis within the popliteal–femoral venous segment upon clinical presentation with a venous ulcer and subsequent successful treatment with venoplasty
Diagnosis of stenosis within the popliteal–femoral venous segment upon clinical presentation with a venous ulcer and subsequent successful treatment with venoplasty Open
This case study reports the diagnosis and treatment of a lower limb venous ulcer with abnormal underlying venous pathology. One male patient presented with bilateral varicose veins and a right lower limb ulcer. Upon investigation, full-leg…
View article: Successful release of an entrapped circular mapping catheter using a snare and a multidisciplinary approach
Successful release of an entrapped circular mapping catheter using a snare and a multidisciplinary approach Open
A 44-year-old attended for pulmonary vein isolation procedure as treatment for highly symptomatic, paroxysmal atrial fibrillation. SLO sheaths (St Jude Medical, USA) were used to facilitate introduction of a 3.5-mm irrigated tip ablation c…