Daniel C. Gray
YOU?
Author Swipe
View article: Data from Oncogenic BRAF Is Required for Tumor Growth and Maintenance in Melanoma Models
Data from Oncogenic BRAF Is Required for Tumor Growth and Maintenance in Melanoma Models Open
The usual paradigm for developing kinase inhibitors in oncology is to use a high-affinity proof-of-concept inhibitor with acceptable metabolic properties for key target validation experiments. This approach requires substantial medicinal c…
View article: Supplementary Figures 1-3 from Oncogenic BRAF Is Required for Tumor Growth and Maintenance in Melanoma Models
Supplementary Figures 1-3 from Oncogenic BRAF Is Required for Tumor Growth and Maintenance in Melanoma Models Open
Supplementary Figures 1-3 from Oncogenic BRAF Is Required for Tumor Growth and Maintenance in Melanoma Models
View article: Data from Oncogenic BRAF Is Required for Tumor Growth and Maintenance in Melanoma Models
Data from Oncogenic BRAF Is Required for Tumor Growth and Maintenance in Melanoma Models Open
The usual paradigm for developing kinase inhibitors in oncology is to use a high-affinity proof-of-concept inhibitor with acceptable metabolic properties for key target validation experiments. This approach requires substantial medicinal c…
View article: Supplementary Figures 1-3 from Oncogenic BRAF Is Required for Tumor Growth and Maintenance in Melanoma Models
Supplementary Figures 1-3 from Oncogenic BRAF Is Required for Tumor Growth and Maintenance in Melanoma Models Open
Supplementary Figures 1-3 from Oncogenic BRAF Is Required for Tumor Growth and Maintenance in Melanoma Models
View article: Development and Validation of a Mobile Application to Detect Visual Dysfunction Following Mild Traumatic Brain Injury
Development and Validation of a Mobile Application to Detect Visual Dysfunction Following Mild Traumatic Brain Injury Open
Introduction Following mild traumatic brain injury, visual dysfunction is a common occurrence, yet the condition often goes undiagnosed. A mobile application was developed to measure aspects of visual acuity and oculomotor function. The ai…
View article: Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface
Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface Open
Significance This manuscript reports on a member of the FK506/rapamycin family, WDB002, and the realization that FKBP-mediated recognition is a genetically programmable modality that enables engagement of topologically flat targets. FKBP-m…
View article: Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling
Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling Open
Significance Apoptosis, a type of programmed cell death, is critical for the removal of diseased or superfluous cells and is essential in maintaining tissue homeostasis. At the molecular level, apoptosis leads to the highly coordinated sel…