Explanipedia

Hippocampal neural stem cell-derived extracellular vesicles modulate microglia to promote resilience against tau oligomers Open

Salvatore Saieva, Jutatip Guptarak, Wen-Ru Zhang, Daniel C. Jupiter, Michela Marcatti · 2025

Neural stem cells and adult hippocampal neurogenesis modulate synaptic plasticity and cognitive function. Neural stem cells secrete extracellular vesicles - microvesicles carrying biomolecular cargos - that modulate the function of other c…

Sagittal Position of Nail in Talus Affects Tibiotalocalcaneal Arthrodesis Outcomes Open

Sean O’Leary, Navneet K. Venugopal, Ariadna Robledo, Roshan B. Tom, Daniel C. Jupiter , et al. · 2025

Background Tibiotalocalcaneal (TTC) nails are commonly used implants for hindfoot arthrodesis. This study evaluated the relationship between the sagittal placement of the nail—specifically, more anterior versus more posterior positioning w…

Genotype-Specific Electroretinogram Signatures in Drosophila : Implications for Neurodegeneration Models Using w1118 Backgrounds Open

N.A. Manuel, Malav Mallipudi, Arya Gajwani, Sahana Murthy, Daniel C. Jupiter , et al. · 2024

Drosophila melanogaster serves as a powerful model for studying neurodegenerative diseases, often employing the GAL4-UAS system for targeted gene expression. Electroretinograms (ERGs) provide a robust in vivo functional readout of neuronal…

Cognitive integrity in Non‐Demented Individuals with Alzheimer’s Disease Neuropathology is associated with preservation and remodeling of dendritic spines Open

Jutatip Guptarak, Pietro Scaduto, Batbayar Tumurbaatar, Daniel C. Jupiter, Giulio Taglialatela , et al. · 2024

Background Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder leading to dementia. The existence of individuals who remain cognitively intact despite presenting histopathological signs of AD, here referred to as “Non…

Reviewing the Raters: A Study of Orthopedic Oncology Rating Outcomes During COVID-19 Open

Megna Panchbhavi, Alexander Yu, Jie Chen, John C. Hagedorn, Cory Janney , et al. · 2024

Background During the 2020 COVID outbreak, telemedicine usage rates skyrocketed. We investigated the effect of telemedicine availability and demographic factors on orthopedic oncologist ratings and review rates. We also investigated patien…

A New Clinical Test to Evaluate Intrinsic Foot Muscle Function Open

Megna Panchbhavi, Michael C. Poliner, P. J. Finegan, Daniel C. Jupiter · 2024

Background: Intrinsic foot muscle weakness has been implicated in a wide range of forefoot conditions and is typically measured by the paper grip test. The proposed “knuckle test” is intended to evaluate intrinsic foot muscle function, in …

Surgical Specialty Outcome Differences for Major Spinal Procedures in Low-Acuity Patients Open

A. W. Price, Christopher File, Alvin LeBlanc, Nathan Fredricks, Rylie Ju , et al. · 2024

Study Design Retrospective Cohort Study. Objectives There is an ongoing debate as to the influence of specialty training on spine surgery. Alomari et al. indicated the influence of specialty on ACDF procedures. However, deeper analysis int…

Case-control analysis of hip fractures with concurrent benzodiazepine and opioid use and surgery class at a single teaching institution Open

Andrew Z. Coskey, Ernst J Nicanord, Margaret A. Goodwin, Haris Vakil, Daniel C. Jupiter , et al. · 2024

In this study, we analyze the relationship between polypharmacy and surgical treatment in a population at a single teaching institution. The design of the study is a case-control analysis of hip fractures. The setting is at a single teachi…

Trajectories of Diabetes-Related Sequelae for Identifying Transition Probabilities, and Optimal Timepoints for Prevention of Ulceration, Infection, and Amputation Open

Daniel C. Jupiter, Yuanyi Zhang, Naohiro Shibuya · 2024

Cognitive integrity in Non‐Demented Individuals with Alzheimer's Neuropathology is associated with preservation and remodeling of dendritic spines Open

Jutatip Guptarak, Pietro Scaduto, Batbayar Tumurbaatar, Wen Ru Zhang, Daniel C. Jupiter , et al. · 2024

INTRODUCTION Individuals referred to as Non‐Demented with Alzheimer's Neuropathology (NDAN) exhibit cognitive resilience despite presenting Alzheimer's disease (AD) histopathological signs. Investigating the mechanisms behind this resilien…

Effectiveness of Concurrent Ankle Arthroscopy During Open Reduction and Internal Fixation of Malleolar Fractures in Prevention of Common Short-Term Complications Open

Naohiro Shibuya, Daniel C. Jupiter · 2024

Reduced Prevalence of Parkinson’s Disease in Patients Prescribed Calcineurin Inhibitors Open

Jacqueline Silva, Daniel C. Jupiter, Giulio Taglialatela · 2024

Background: Preclinical evidence suggests calcineurin inhibitors (CNIs) combat α-synuclein-induced neuronal dysfunction and motor impairments. However, whether CNIs prevent or treat Parkinson’s disease (PD) in humans has never been investi…

Intermediate-Term Follow-Up of Biopro® Modular Thumb Implant for Carpometacarpal Arthritis Open

Alexander T Goodsett, Daniel C. Jupiter, Navneet K. Venugopal, John J. Faillace · 2024

Purpose: Basilar thumb arthritis is a common condition that can be associated with significant disability. While surgical management has historically consisted of trapeziectomy-type procedures, hemiarthroplasty has become an increasingly c…

The Effect of Limb Salvage Efforts in Different Age Groups: Relationships Between Major and Minor Amputations Open

Wenye Song, Javier La Fontaine, Naohiro Shibuya, John Prochaska, Daniel C. Jupiter · 2024

Preserved Autophagy in Cognitive Intact Non‐Demented Individuals with Alzheimer’s Neuropathology Open

Anna Fracassi, Batbayar Tumurbaatar, Pietro Scaduto, Jutatip Guptarak, Daniel C. Jupiter , et al. · 2023

Background Alzheimer’s disease (AD) is a terminal neurodegenerative disease and the most common cause of dementia. Notably, some individuals, here referred to as Non‐Demented individuals with Alzheimer’s Neuropathology (NDAN) are cognitive…

Radiographic Anatomy of the Lateral Ankle Ligament Complex: A Cadaveric Study Open

Jordan B. Robbins, Shepheard A. Stahel, Randal P. Morris, Daniel C. Jupiter, Jie Chen , et al. · 2023

Background: When lateral ankle sprains progress into chronic lateral ankle instability (CLAI), restoring precise anatomic relationships of the lateral ankle ligament complex (LALC) surgically is complex. This study quantifies the radiograp…

Radiographic Anatomy of the Lateral Ankle Ligament Complex: A Cadaveric Study Open

P Tansey, Jordan M. Robbins, Shepherd A. Stahel, Randal P. Morris, Daniel C. Jupiter , et al. · 2023

Category: Ankle; Sports Introduction/Purpose: Lateral ankle sprains are common orthopedic injuries that may progress on as chronic lateral ankle instability (CLAI). Great care must be taken to restore precise anatomic relationships of the …

Reduced Prevalence of Dementia in Patients Prescribed Tacrolimus, Sirolimus, or Cyclosporine Open

Jacqueline Silva, Giulio Taglialatela, Daniel C. Jupiter · 2023

Background: Evidence suggests patients prescribed calcineurin inhibitors (CNIs) have a reduced prevalence of dementia, including Alzheimer’s disease (AD); however, this result has never been replicated in a large cohort and the involved me…

Preoperative Serum Albumin and Other Risk Factors Related to 30-Day Postoperative Complications in Total Ankle Arthroplasty Open

Jeffrey T. Bowcutt, Naohiro Shibuya, Daniel C. Jupiter · 2023

Retrospective Analyses of Dementia Outcomes in Patients Prescribed Immunosuppressants Open

Jacqueline Silva, Daniel C. Jupiter, Giulio Taglialatela · 2023

Preserved autophagy in cognitively intact non‐demented individuals with Alzheimer's neuropathology Open

Batbayar Tumurbaatar, Anna Fracassi, Pietro Scaduto, Jutatip Guptarak, Randall L. Woltjer , et al. · 2023

INTRODUCTION Growing evidence supports that dysfunctional autophagy, the major cell mechanism responsible for removing protein aggregates and a route of clearance for Tau in healthy neurons, is a major finding in demented Alzheimer's disea…

Five-Factor Modified Frailty Index as a Predictor of Complications Following Total Ankle Arthroplasty Open

Lauren K. Lewis, Daniel C. Jupiter, Vinod K. Panchbhavi, Jie Chen · 2023

Introduction Ankle arthritis adversely affects patients’ function and quality of life. Treatment options for end-stage ankle arthritis include total ankle arthroplasty (TAA). A 5-item modified frailty index (mFI-5) has predicted adverse ou…

The Effects of COVID-19 on Orthopaedic Surgery Training Programs in the United States Open

Shivan N Chokshi, Tsola A Efejuku, Jie Chen, Daniel C. Jupiter, Jeremy S. Somerson , et al. · 2023

Introduction: This study investigates the effects of the COVID-19 pandemic on medical education, research opportunities, and mental health in orthopaedic surgical training programs. Methods: A survey was sent to the 177 Electronic Residenc…

Development and Evaluation of Rehabilitation Service Areas for the United States Open

Timothy Reistetter, Julianna M. Dean, Allen Haas, John Prochaska, Daniel C. Jupiter , et al. · 2023

Functional Outcomes and Patient Satisfaction with Anterior Talofibular Ligament Repair Using Ultrasonically Interdigitated Suture Anchors Open

Jordan B. Robbins, Michael Nemec, Waleed Cassis, Kiya Shazadeh Safavi, Daniel C. Jupiter , et al. · 2023

This study evaluates the clinical efficacy and patient satisfaction for the Broström-Gould repair of the anterior talofibular ligament using an ultrasonically interdigitated suture anchor. Medical records for patients who underwent open Br…

Digital Biomarkers of Gait and Balance in Diabetic Foot, Measurable by Wearable Inertial Measurement Units: A Mini Review Open

Gu Eon Kang, Angeloh Stout, Ke’Vaughn Waldon, Seung-Min Kang, Amanda L. Killeen , et al. · 2022

People with diabetic foot frequently exhibit gait and balance dysfunction. Recent advances in wearable inertial measurement units (IMUs) enable to assess some of the gait and balance dysfunction associated with diabetic foot (i.e., digital…

Current Gender Diversity and Geographic Trends Among Orthopaedic Sports Medicine Surgeons in the United States Open

Kristine Kocjan, Kiya Shazadeh Safavi, Brett Flaherty, Aryan Rezvani, Daniel C. Jupiter , et al. · 2022

Background: Female representation varies geographically among orthopaedic residency programs, with the southern region of the United States reported as having relatively lower rates of female orthopaedic surgeons. Purpose: To determine the…

Return to Play and Performance Measures for National Football League Athletes Following Operative Ankle Fractures Open

Jordan M. Robbins, Daniel C. Jupiter, Vinod K. Panchbhavi, William M. Weiss, John C. Hagedorn , et al. · 2022

Category: Sports; Ankle; Trauma Introduction/Purpose: Ankle fractures are common injuries in the National Football League (NFL). Yet, there is a need for deeper understanding about the impacts of surgically managed ankle fractures on athle…

Comparative Analysis of Hallux Valgus Surgical Techniques: A Systematic Review Open

Atish S. Amin, Shahrukh R. Ali, Mayurkumar S. Patel, Tyler B. Nsekpong, Brian J. Beasley , et al. · 2022

Category: Bunion; Midfoot/Forefoot Introduction/Purpose: Hallux valgus is a foot deformity where the distal portion of the hallux deviates laterally, forming a bunion. Here we review three surgical techniques for correction of the deformit…

Digital Biomarkers of Poor Gait and Balance in Diabetic Foot, Measurable by Wearables: A Review of Literature Open

Gu Eon Kang, Angeloh Stout, Ke’Vaughn Waldon, Seungmin Kang, Amanda L. Killeen , et al. · 2022

People with diabetic foot frequently exhibit poor gait and balance. However, there is no review to inform digital biomarkers of poor gait and balance related to diabetic foot, measurable by wearables outside traditional gait laboratories. …

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