Daniel C. Lowes
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View article: Altered striatal dopamine regulation in <i>ADGRL3</i> knockout mice
Altered striatal dopamine regulation in <i>ADGRL3</i> knockout mice Open
Dopaminergic signaling is essential for regulating movement, learning, and reward. Disruptions in this system are linked to neuropsychiatric disorders such as ADHD. ADGRL3, an adhesion G protein-coupled receptor highly expressed in the bra…
View article: Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels
Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels Open
In the striatum, acetylcholine (ACh) neuron activity is modulated co-incident with dopamine (DA) release in response to unpredicted rewards and reward-predicting cues and both neuromodulators are thought to regulate each other. While this …
View article: Author response: Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels
Author response: Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract In the striatum, acety…
View article: Ventral tegmental area GABA neurons mediate stress-induced anhedonia
Ventral tegmental area GABA neurons mediate stress-induced anhedonia Open
Stressful experiences frequently precede depressive episodes 1 . Depression results in anhedonia, or disrupted reward-seeking, in most patients 2 . In humans 3,4 and rodents 5,6 , stress can disrupt reward-seeking, providing a potential me…
View article: Postsynaptic integrative properties of dorsal CA1 pyramidal neuron subpopulations
Postsynaptic integrative properties of dorsal CA1 pyramidal neuron subpopulations Open
The population activity of CA1 pyramidal neurons (PNs) segregates along anatomical axes with different behaviors, suggesting that CA1 PNs are functionally subspecialized based on somatic location. In dorsal CA1, spatial encoding is biased …
View article: Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain
Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain Open
Significance Neuronal inhibition in the CNS occurs via two mechanisms. Synaptic inhibition is transient and localized; extrasynaptic inhibition is continuous and diffuse. Glycine receptor (GlyR)-mediated synaptic inhibition in spinal cord …
View article: Medial and Lateral Entorhinal Cortex Differentially Excite Deep versus Superficial CA1 Pyramidal Neurons
Medial and Lateral Entorhinal Cortex Differentially Excite Deep versus Superficial CA1 Pyramidal Neurons Open
Although hippocampal CA1 pyramidal neurons (PNs) were thought to comprise a uniform population, recent evidence supports two distinct sublayers along the radial axis, with deep neurons more likely to form place cells than superficial neuro…