Daniel C. Pan
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View article: A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens
A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens Open
View article: Ultrasound‐mediated delivery of flexibility‐tunable polymer drug conjugates for treating glioblastoma
Ultrasound‐mediated delivery of flexibility‐tunable polymer drug conjugates for treating glioblastoma Open
Effective chemotherapy delivery for glioblastoma multiforme (GBM) is limited by drug transport across the blood–brain barrier and poor efficacy of single agents. Polymer–drug conjugates can be used to deliver drug combinations with a ratio…
View article: A dual macrophage polarizer conjugate for synergistic melanoma therapy
A dual macrophage polarizer conjugate for synergistic melanoma therapy Open
View article: Erythrocyte-driven immunization via biomimicry of their natural antigen-presenting function
Erythrocyte-driven immunization via biomimicry of their natural antigen-presenting function Open
Significance Red blood cells perform the unique function of capturing certain pathogens in blood and presenting them to the immune cells in the spleen. We developed a strategy based on this innate immune function of red blood cells to deli…
View article: Hyaluronic a<scp>cid–doxorubicin</scp> nanoparticles for targeted treatment of colorectal cancer
Hyaluronic a<span>cid–doxorubicin</span> nanoparticles for targeted treatment of colorectal cancer Open
Colorectal cancer, common in both men and women, occurs when tumors form in the linings of the colon. Common treatments of colorectal cancer include surgery, chemotherapy, and radiation therapy; however, many colorectal cancer treatments o…
View article: Cellular backpacks for macrophage immunotherapy
Cellular backpacks for macrophage immunotherapy Open
Backpacks enable a new strategy to control cellular phenotypes in vivo by attaching to macrophages and guiding their phenotypes.
View article: Nanoparticle Properties Modulate Their Attachment and Effect on Carrier Red Blood Cells
Nanoparticle Properties Modulate Their Attachment and Effect on Carrier Red Blood Cells Open
Attachment of nanoparticles (NPs) to the surface of carrier red blood cells (RBCs) profoundly alters their interactions with the host organism, decelerating NP clearance from the bloodstream while enabling NP transfer from the RBC surface …
View article: Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude Open
View article: The effects of inhaled multi-walled carbon nanotubes on blood pressure and cardiac function
The effects of inhaled multi-walled carbon nanotubes on blood pressure and cardiac function Open
View article: Ferritin Nanocages with Biologically Orthogonal Conjugation for Vascular Targeting and Imaging
Ferritin Nanocages with Biologically Orthogonal Conjugation for Vascular Targeting and Imaging Open
Genetic incorporation of biologically orthogonal functional groups into macromolecules has the potential to yield efficient, controlled, reproducible, site-specific conjugation of affinity ligands, contrast agents, or therapeutic cargoes. …
View article: Biocompatible coupling of therapeutic fusion proteins to human erythrocytes
Biocompatible coupling of therapeutic fusion proteins to human erythrocytes Open
Key Points Thrombomodulin was fused to scFvs targeting RhCE (Rh17 epitope) and band 3/GPA (Wrb epitope). Fusion proteins were efficacious in a humanized microfluidic model of inflammatory thrombosis.
View article: Nanoparticle Properties Modulate Their Attachment and Effect on Carrier Red Blood Cells
Nanoparticle Properties Modulate Their Attachment and Effect on Carrier Red Blood Cells Open
View article: Mechanisms that determine nanocarrier targeting to healthy versus inflamed lung regions
Mechanisms that determine nanocarrier targeting to healthy versus inflamed lung regions Open
View article: The Effect of Polymeric Nanoparticles on Biocompatibility of Carrier Red Blood Cells
The Effect of Polymeric Nanoparticles on Biocompatibility of Carrier Red Blood Cells Open
Red blood cells (RBCs) can be used for vascular delivery of encapsulated or surface-bound drugs and carriers. Coupling to RBC prolongs circulation of nanoparticles (NP, 200 nm spheres, a conventional model of polymeric drug delivery carrie…
View article: Long-circulating Janus nanoparticles made by electrohydrodynamic co-jetting for systemic drug delivery applications
Long-circulating Janus nanoparticles made by electrohydrodynamic co-jetting for systemic drug delivery applications Open
Background: Nanoparticles with controlled physical properties have been widely used for controlled release applications. In addition to shape, the anisotropic nature of the particles can be an important design criterion to ensure se…
View article: Delivery of Drugs Bound to erythrocytes: New Avenues for an Old Intravascular Carrier
Delivery of Drugs Bound to erythrocytes: New Avenues for an Old Intravascular Carrier Open
For several decades, researchers have used erythrocytes for drug delivery of a wide variety of therapeutics in order to improve their pharmacokinetics, biodistribution, controlled release and pharmacodynamics. Approaches include encapsulat…