Daniel Candinas
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View article: Fast and user-friendly multi-spectra Mueller matrix polarimeter for fresh tissue biopsy imaging
Fast and user-friendly multi-spectra Mueller matrix polarimeter for fresh tissue biopsy imaging Open
Mueller Matrix polarimetry (MMP) characterizes changes in light polarization after interacting with a medium, providing insights into tissue microstructure. Combined with multispectral (MS) imaging cameras, MS-MMP offers a novel way to qui…
View article: DNA Replication Stress in Metabolic Dysfunction-Associated Steatohepatitis
DNA Replication Stress in Metabolic Dysfunction-Associated Steatohepatitis Open
Background MASLD is an increasing health global problem characterized by the accumulation of liver-fat. MASLD patients can progress to MASH, a more severe stage of the disease characterized by liver inflammation and an oxidative stress bac…
View article: Trends and Perioperative Outcomes in Gastric Cancer Surgery in Switzerland: A National Inpatient Database Analysis (1998–2021)
Trends and Perioperative Outcomes in Gastric Cancer Surgery in Switzerland: A National Inpatient Database Analysis (1998–2021) Open
Background Volume–outcome relationships have driven the implementation of minimum case volume regulations for various surgical procedures under the framework of Highly Specialised Medicine (HSM) in Switzerland. However, the regulation of g…
View article: Recipient‐Donor Sex Constellation in Liver Transplantation for Hepatocellular Carcinoma—An <scp>ELTR</scp> Study
Recipient‐Donor Sex Constellation in Liver Transplantation for Hepatocellular Carcinoma—An <span>ELTR</span> Study Open
Background & Aims Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related death worldwide. Liver transplantation (LT) is a curative treatment option. We investigated survival outcomes based on recipient‐donor sex conste…
View article: In vivo DNA replication dynamics unveil aging-dependent replication stress
In vivo DNA replication dynamics unveil aging-dependent replication stress Open
The genome duplication program is affected by multiple factors in vivo, including developmental cues, genotoxic stress, and aging. Here, we monitored DNA replication initiation dynamics in regenerating livers of young and old mice after pa…
View article: Online 3D reconstruction and dense tracking in endoscopic videos
Online 3D reconstruction and dense tracking in endoscopic videos Open
3D scene reconstruction from stereo endoscopic video data is crucial for advancing surgical interventions. In this work, we present an online framework for online, dense 3D scene reconstruction and tracking, aimed at enhancing surgical sce…
View article: Noise in the operating room coincides with surgical difficulty
Noise in the operating room coincides with surgical difficulty Open
Background Noise in the operating room has been shown to distract the surgical team and to be associated with postoperative complications. It is, however, unclear whether complications after noisy operations are the result of objective or …
View article: Glued suture-less peritoneum closure in laparoscopic inguinal hernia repair reduces acute postoperative pain
Glued suture-less peritoneum closure in laparoscopic inguinal hernia repair reduces acute postoperative pain Open
Inguinal hernia repair is performed more than 20 million times per annum, representing a significant health and economic burden. Over the last three decades, significant technical advances have started to reduce the invasiveness of these s…
View article: Pathological Complete Response after Radio Chemotherapy and Esophagectomy – false Sense of Security?
Pathological Complete Response after Radio Chemotherapy and Esophagectomy – false Sense of Security? Open
Background Esophageal cancer (EC) is associated with a high morbidity and mortality, even in a curative treatment approach. The current standard of care for curative treatment of EC consists of neoadjuvant radio chemotherapy (RCT) followed…
View article: Spatial Transcriptomics Reveals Interaction of Injury-Derived Osteopontin with Mesothelial Cells in Serosal Scarring
Spatial Transcriptomics Reveals Interaction of Injury-Derived Osteopontin with Mesothelial Cells in Serosal Scarring Open
Background Abdominal surgeries are often live-saving procedures. However, surgical interventions in the peritoneal cavity can cause the formation of post-surgical adhesions. These irreversible scar bands can trigger severe complications, s…
View article: Selective Inhibition of Hepatocyte Claudin-3 Ameliorates Fibrotic and Cholestatic Liver Damage by Enhancing Bicarbonate Secretion and Bile Dynamics.
Selective Inhibition of Hepatocyte Claudin-3 Ameliorates Fibrotic and Cholestatic Liver Damage by Enhancing Bicarbonate Secretion and Bile Dynamics. Open
Background Cholestatic-fibrotic liver diseases have a high unmet medical need. Tight junctions, which maintain the blood-biliary-barrier in the liver, have important biological functions that impact cholestatic diseases. A main component o…
View article: Transgastric Laparoscopic Resection of Gastric Submucosal Tumors: An Alternative Approach in Anatomically Challenging Locations?
Transgastric Laparoscopic Resection of Gastric Submucosal Tumors: An Alternative Approach in Anatomically Challenging Locations? Open
Background Surgical resection remains the recommended method in treatment for patients with Gastrointestinal stromal tumors (GIST). However, resection in anatomically challenging locations, e.g., lesser curvature of the stomach or gastroes…
View article: Overall Survival in Patients with Esophageal Cancer and Clinical Complete Response after Radio Chemotherapy: Should a Watchful Waiting Strategy be the new Standard of Care?
Overall Survival in Patients with Esophageal Cancer and Clinical Complete Response after Radio Chemotherapy: Should a Watchful Waiting Strategy be the new Standard of Care? Open
Background The current standard of care for curative treatment of esophageal cancer (EC) consists of neoadjuvant radio chemotherapy (RCT) followed by resection. However, an organ-sparing approach with a watchful waiting (WW) strategy and r…
View article: Recipient donor sex combinations in solid organ transplantation and impact on clinical outcome: A scoping review
Recipient donor sex combinations in solid organ transplantation and impact on clinical outcome: A scoping review Open
Introduction Solid organ transplantation (SOT) is a lifesaving treatment for end‐stage organ failure. Although many factors affect the success of organ transplantation, recipient and donor sex are important biological factors influencing t…
View article: Abstracts Surgical Research
Abstracts Surgical Research Open
Background:The perspective of patients has historically not been heard in both clinical research and care.Currently, just few scientific institutions provide sustainable mechanisms for patient involvement in research projects.Nevertheless,…
View article: Longitudinal analysis of caloric requirements in critically ill trauma patients: a retrospective cohort study
Longitudinal analysis of caloric requirements in critically ill trauma patients: a retrospective cohort study Open
Purpose Nutrition is of paramount importance in critically ill trauma patients. However, adequate supply is difficult to achieve, as caloric requirements are unknown. This study investigated caloric requirements over time, based on indirec…
View article: Physical activity decreases in patients on the liver transplant waiting list and influences postoperative outcome—a prospective cohort study
Physical activity decreases in patients on the liver transplant waiting list and influences postoperative outcome—a prospective cohort study Open
In patients listed for LT, MPA decreased over time, showing a significant association with adverse outcome, specifically after week 30 on the waiting list. Our data support the implementation of routine pre-habilitation in patients awaitin…
View article: The trajectory of anti-recEm18 antibody levels determines follow-up after curative resection of hepatic alveolar echinococcosis
The trajectory of anti-recEm18 antibody levels determines follow-up after curative resection of hepatic alveolar echinococcosis Open
In patients with preoperative elevated values, anti-recEm18 confirms curative surgery at 12 months follow-up and allows for long-term surveillance.
View article: Comparison of transarterial bland embolization and drug-eluting beads transarterial chemoembolization for very early and early hepatocellular carcinoma not amenable for surgery or ablation: a single center retrospective data analysis
Comparison of transarterial bland embolization and drug-eluting beads transarterial chemoembolization for very early and early hepatocellular carcinoma not amenable for surgery or ablation: a single center retrospective data analysis Open
Compared with DEB-TACE, TAE is an equally effective and save therapy for very early and early HCC not amenable for resection or ablation without differences in local tumor control and OS.
View article: No signs of check-list fatigue – introducing the StOP? intra-operative briefing enhances the quality of an established pre-operative briefing in a pre-post intervention study
No signs of check-list fatigue – introducing the StOP? intra-operative briefing enhances the quality of an established pre-operative briefing in a pre-post intervention study Open
Background The team timeout (TTO) is a safety checklist to be performed by the surgical team prior to incision. Exchange of critical information is, however, important not only before but also during an operation and members of surgical te…
View article: Anti-Recem18 Antibody Levels are Associated with Lesion Size and Determine Follow-Up after Resection of Hepatic Alveolar Echinococcosis
Anti-Recem18 Antibody Levels are Associated with Lesion Size and Determine Follow-Up after Resection of Hepatic Alveolar Echinococcosis Open
Background Best monitoring practices for patients after resection of hepatic alveolar echinococcosis remain unclear. Aims The current study tested if assessment of anti-recEm18 allows for postsurgical patient surveillance. Methods A retros…
View article: Feasibility and Safety of Intraoperative Bile Duct Clearance by Sphincter Oddi Balloon Dilatation: A Prospective Observational Pilot Study
Feasibility and Safety of Intraoperative Bile Duct Clearance by Sphincter Oddi Balloon Dilatation: A Prospective Observational Pilot Study Open
Background Concomitant cholecysto- and choledocholithiasis is common. Standard treatments are ERCP followed by cholecystectomy or laparoendoscopic rendez-vous. ERCP has drawbacks such as post-ERCP-pancreatitis (5%) or -bleeding (5%) and po…