Daniel Catchpoole
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View article: Clinical and germline risk factors for multiple treatment-related toxicities in pediatric acute lymphoblastic leukemia
Clinical and germline risk factors for multiple treatment-related toxicities in pediatric acute lymphoblastic leukemia Open
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View article: Lossless Compression with Trie-Based Shared Dictionary for Omics Data in Edge–Cloud Frameworks
Lossless Compression with Trie-Based Shared Dictionary for Omics Data in Edge–Cloud Frameworks Open
The growing complexity and volume of genomic and omics data present critical challenges for storage, transfer, and analysis in edge–cloud platforms. Existing compression techniques often involve trade-offs between efficiency and speed, req…
View article: Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastoma
Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastoma Open
View article: Table S4 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S4 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Copy number changes
View article: Table S3 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S3 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
WES results
View article: Data from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Data from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Wilms tumor, the most common pediatric kidney cancer, resembles embryonic renal progenitors. Currently, there are no ways to therapeutically target Wilms tumor driver mutations, such as in the microRNA processing gene DROSHA. In thi…
View article: Table S7 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S7 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Metabolomics
View article: Table S4 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S4 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Copy number changes
View article: Table S2 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S2 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Targeted genes
View article: Figure S2 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S2 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S2. (A) Mutational burden in Wilms tumors compared to other tumor types in TCGA. (B) Most common SNV types in Wilms tumors analyzed by WES. (C) SNV types in Wilms tumor compared to subtypes of renal cell carcinoma. (D)…
View article: Table S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Fusions
View article: Table S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Tumors list
View article: Table S2 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S2 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Targeted genes
View article: Table S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Tumors list
View article: Figure S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
(A) Landscape of mutations identified by whole exome sequencing. (B) Variants detected by WGS in Wilms tumors. A red “g” represents gain of chromosome 8p or 12p.
View article: Table S6 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S6 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
MicroRNA sequencing
View article: Figure S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
(A) Landscape of mutations identified by whole exome sequencing. (B) Variants detected by WGS in Wilms tumors. A red “g” represents gain of chromosome 8p or 12p.
View article: Table S7 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S7 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Metabolomics
View article: Supplementary Figure legends and Table names from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Supplementary Figure legends and Table names from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure legends and Table names
View article: Figure S6 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S6 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S6. Metabolomics of Wilms tumors were used to determine differential abundance of metabolites, expressed as log2-fold-change in tumors with microRNA processing mutations versus without such mutations, demonstrating tha…
View article: Data from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Data from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Wilms tumor, the most common pediatric kidney cancer, resembles embryonic renal progenitors. Currently, there are no ways to therapeutically target Wilms tumor driver mutations, such as in the microRNA processing gene DROSHA. In thi…
View article: Figure S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S5. Structure of DROSHA RNase IIIb metal-binding pocket.
View article: Table S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Fusions
View article: Figure S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S5. Structure of DROSHA RNase IIIb metal-binding pocket.
View article: Figure S6 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S6 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S6. Metabolomics of Wilms tumors were used to determine differential abundance of metabolites, expressed as log2-fold-change in tumors with microRNA processing mutations versus without such mutations, demonstrating tha…
View article: Figure S3 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S3 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S3. (A) GSEA of mutational classes matched to transcriptional signatures in UTSW/Westmead tumors. (B) GSEA enrichment of “hallmark” gene sets in Wilms tumors with miRNA processing mutations.
View article: Figure S2 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S2 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S2. (A) Mutational burden in Wilms tumors compared to other tumor types in TCGA. (B) Most common SNV types in Wilms tumors analyzed by WES. (C) SNV types in Wilms tumor compared to subtypes of renal cell carcinoma. (D)…
View article: Figure S4 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S4 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S4. (A) TARGET tumors, by mutational class. (B,C) GSEA of mutational classes matched to transcriptional signatures in TARGET tumors; NES, normalized enrichment score.
View article: Figure S4 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S4 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S4. (A) TARGET tumors, by mutational class. (B,C) GSEA of mutational classes matched to transcriptional signatures in TARGET tumors; NES, normalized enrichment score.
View article: Figure S3 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S3 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S3. (A) GSEA of mutational classes matched to transcriptional signatures in UTSW/Westmead tumors. (B) GSEA enrichment of “hallmark” gene sets in Wilms tumors with miRNA processing mutations.