Tak Mao Chan
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View article: Cardiovascular disease as a mediator in the relationship between lifestyle risk factors and cognitive outcomes: a scoping review
Cardiovascular disease as a mediator in the relationship between lifestyle risk factors and cognitive outcomes: a scoping review Open
Dementia is a major global health challenge and lifestyle modification is a key prevention strategy. Cardiovascular disease (CVD) is hypothesized to mediate lifestyle–dementia relationships, but empirical evidence is unclear. Mediation ana…
View article: Colchicine for the Secondary Prevention of Cardiovascular Diseases: A Cumulative-Dose Meta-analysis of Randomized Controlled Trials including 31,397 Subjects Worldwide
Colchicine for the Secondary Prevention of Cardiovascular Diseases: A Cumulative-Dose Meta-analysis of Randomized Controlled Trials including 31,397 Subjects Worldwide Open
PROSPERO identifier no. CRD420251003142.
View article: <scp>HLA</scp>‐Typing of Donor‐Origin Cells Enriched From Urine Cell Culture of Kidney Transplanted Recipients
<span>HLA</span>‐Typing of Donor‐Origin Cells Enriched From Urine Cell Culture of Kidney Transplanted Recipients Open
The incomplete or lack of histocompatibility information constitutes a barrier for the early detection and management of de novo donor‐specific antibodies (DSA). To improve the quantity and quality of DNA materials for HLA typing, we devel…
View article: Expanded Hemodialysis with Theranova Compared with Conventional High-Flux Hemodialysis
Expanded Hemodialysis with Theranova Compared with Conventional High-Flux Hemodialysis Open
Key Points This randomized controlled trial confirms that medium cutoff hemodialysis (MCO-HD) was safe and well tolerated over a 12-month period in patients on twice-weekly hemodialysis. MCO-HD was associated with a transient reduction of …
View article: A long term bone and renal safety of TAF treatment on renal transplant recipients
A long term bone and renal safety of TAF treatment on renal transplant recipients Open
Our results suggest that TAF provides favorable efficacy, renal safety, and tolerability in KTRs. ETV also provided effective and sustainable viral suppression. TAF may offer additional advantages such as no concern of viral resistance and…
View article: P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis
P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis Open
Cancer adhesion to the mesothelium is critical for peritoneal metastasis, but how metastatic cells adapt to the biomechanical microenvironment remains unclear. Our study demonstrates that highly metastatic (HM), but not non-metastatic, ova…
View article: Efficacy and safety of guselkumab in patients with active lupus nephritis: results from a phase 2, randomized, placebo-controlled study
Efficacy and safety of guselkumab in patients with active lupus nephritis: results from a phase 2, randomized, placebo-controlled study Open
Objective Evaluate the efficacy and safety of guselkumab, an IL-23p19-subunit inhibitor, in a phase 2, multicentre, randomized, double-blind, placebo-controlled study of patients with active LN. Methods Adults (18–75 years) with active LN …
View article: Ten tips in lupus nephritis management
Ten tips in lupus nephritis management Open
Lupus nephritis is an important cause of severe glomerulonephritis, and a leading cause of kidney failure in young adults. While the disease can lead to rapid destruction of nephrons if untreated, there are effective therapies to reverse t…
View article: Long-Term Kidney Outcome of Lupus Nephritis by Renal Response Status
Long-Term Kidney Outcome of Lupus Nephritis by Renal Response Status Open
In Chinese patients with LN, mPERR and mCRR at 2 years postbiopsy predict superior long-term kidney outcomes and lower CKD progression risk.
View article: Cluster of differentiation-44 as a novel biomarker of lupus nephritis and its role in kidney inflammation and fibrosis
Cluster of differentiation-44 as a novel biomarker of lupus nephritis and its role in kidney inflammation and fibrosis Open
Introduction CD44 is a transmembrane glycoprotein implicated in tissue inflammation and fibrosis. We investigated its role in kidney inflammation and fibrosis in a murine model of lupus nephritis (LN), and the clinico-pathological associat…
View article: Correlation of Urinary Soluble CD163 Levels With Disease Activity and Treatment Response in IgA Nephropathy
Correlation of Urinary Soluble CD163 Levels With Disease Activity and Treatment Response in IgA Nephropathy Open
u-sCD163 is a reliable noninvasive biomarker associated with active pathological lesions in IgAN and can guide glucocorticoid therapy.
View article: P-cadherin mechanoactivates tumor–mesothelium metabolic coupling to promote ovarian cancer metastasis
P-cadherin mechanoactivates tumor–mesothelium metabolic coupling to promote ovarian cancer metastasis Open
Peritoneal metastasis exacerbates the prognosis of ovarian cancer patients. Adhesion of cancer cells to mesothelium is a rate-limiting prerequisite for this process. How metastatic cells sense and respond to the dynamic biomechanical micro…
View article: Palliative care in kidney transplant recipients with graft failure
Palliative care in kidney transplant recipients with graft failure Open
Kidney transplantation is the best renal replacement therapy for patients with end stage kidney disease. It provides longer patient survival and better quality of life than dialysis. The clinical course after kidney transplantation could b…
View article: The Efficacy and Safety of Reduced-Dose Oral Methylprednisolone in High-Risk Immunoglobulin A Nephropathy
The Efficacy and Safety of Reduced-Dose Oral Methylprednisolone in High-Risk Immunoglobulin A Nephropathy Open
Reduced-dose methylprednisolone is effective in improving kidney outcomes in high risk IgAN; however, it is associated with a modestly higher number of SAEs compared to placebo.
View article: Cardiovascular risk factors and complications in patients with systemic lupus erythematosus with and without nephritis: a systematic review and meta-analysis
Cardiovascular risk factors and complications in patients with systemic lupus erythematosus with and without nephritis: a systematic review and meta-analysis Open
Introduction It remains unclear how the presence of renal involvement will affect the cardiovascular (CV) risk factors and complications in patients with SLE. Methods We conducted a systematic review and meta-analysis using PubMed, EMBASE,…
View article: Consensus statement on the management of hyperkalaemia—An<scp>Asia–Pacific</scp>perspective
Consensus statement on the management of hyperkalaemia—An<span>Asia–Pacific</span>perspective Open
Hyperkalaemia is an electrolyte imbalance that impairs muscle function and myocardial excitability, and can potentially lead to fatal arrhythmias and sudden cardiac death. The prevalence of hyperkalaemia is estimated to be 6%–7% worldwide …
View article: Immunogenicity and Safety of the Three-Dose COVID-19 Vaccine Regimen in Patients Receiving Renal Replacement Therapy: A Systematic Review and Meta-Analysis
Immunogenicity and Safety of the Three-Dose COVID-19 Vaccine Regimen in Patients Receiving Renal Replacement Therapy: A Systematic Review and Meta-Analysis Open
Background: A three-dose regimen is the current standard for COVID-19 vaccination, but systematic data on immunogenicity and safety in chronic kidney disease patients remains limited. Objectives: We conducted a meta-analysis on the immunog…
View article: Framework of Guidelines for Management of CKD in Asia
Framework of Guidelines for Management of CKD in Asia Open
Approximately 850 million individuals live with kidney disorders globally.1 Chronic kidney disease (CKD) is an emerging public health concern with a global prevalence of 13.4%.2 The overall prevalence of CKD in Asia is estimated to be 434.…
View article: A PRoliferation-Inducing Ligand (APRIL) in the Pathogenesis of Immunoglobulin A Nephropathy: A Review of the Evidence
A PRoliferation-Inducing Ligand (APRIL) in the Pathogenesis of Immunoglobulin A Nephropathy: A Review of the Evidence Open
A PRoliferation-Inducing Ligand (APRIL), the thirteenth member of the tumor necrosis factor superfamily, plays a key role in the regulation of activated B cells, the survival of long-lived plasma cells, and immunoglobulin (Ig) isotype clas…
View article: A Phase 2 Trial of Sibeprenlimab in Patients with IgA Nephropathy
A Phase 2 Trial of Sibeprenlimab in Patients with IgA Nephropathy Open
In patients with IgA nephropathy, 12 months of treatment with sibeprenlimab resulted in a significantly greater decrease in proteinuria than placebo. (Funded by Visterra; ENVISION ClinicalTrials.gov number, NCT04287985; EudraCT number, 201…