Daniel Chappell
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View article: Association between intraoperative hypotension and postoperative nausea and vomiting: a retrospective cohort study
Association between intraoperative hypotension and postoperative nausea and vomiting: a retrospective cohort study Open
The study demonstrates an association between intraoperative hypotension and early PONV. A more severe decrease of MAP had a pronounced effect.
View article: Treatment of spinal anaesthesia-induced hypotension with cafedrine/theodrenaline versus ephedrine during caesarean section
Treatment of spinal anaesthesia-induced hypotension with cafedrine/theodrenaline versus ephedrine during caesarean section Open
BACKGROUND In Germany, hypotension induced by spinal anaesthesia is commonly treated with a combination of cafedrine hydrochloride (C, 200 mg) and theodrenaline hydrochloride (T, 10 mg) in 2 ml. We compared the effectiveness of C/T with ep…
View article: Bioinformatic Prediction and Therapy Optimization by Artificial Intelligence in Hypotension
Bioinformatic Prediction and Therapy Optimization by Artificial Intelligence in Hypotension Open
Intraoperative hypotension (IOH) is a relevant complication of general anesthesia, representing a major challenge for anesthesiologic management. Depending on the definition of IOH, it occurs in up to 81 % of non-cardiac surgery and is ass…
View article: Natriuretic Peptides as a Prognostic Marker for Delirium in Cardiac Surgery—A Pilot Study
Natriuretic Peptides as a Prognostic Marker for Delirium in Cardiac Surgery—A Pilot Study Open
Background and Objectives: Delirium is a common and major complication subsequent to cardiac surgery. Despite scientific efforts, there are no parameters which reliably predict postoperative delirium. In delirium pathology, natriuretic pep…
View article: A case series on the value of tau and neurofilament protein levels to predict and detect delirium in cardiac surgery patients
A case series on the value of tau and neurofilament protein levels to predict and detect delirium in cardiac surgery patients Open
Tau and NfL might be of benefit to identify patients in cardiac surgery at risk for delirium and to detect patients with the postoperative emergence of delirium.
View article: Should hydroxyethyl starch be banned?
Should hydroxyethyl starch be banned? Open
Roberts and colleagues'1Roberts I Shakur H Bellomo R et al.Hydroxyethyl starch solutions and patient harm.Lancet. 2018; 391: 736Summary Full Text Full Text PDF PubMed Scopus (33) Google Scholar Correspondence in The Lancet asking WHO to su…
View article: The impact of phosphate-balanced crystalloid infusion on acid-base homeostasis (PALANCE study): study protocol for a randomized controlled trial
The impact of phosphate-balanced crystalloid infusion on acid-base homeostasis (PALANCE study): study protocol for a randomized controlled trial Open
EudraCT number 201002422520 . Registered on 30 November 2010.
View article: Regulation of blood flow and volume exchange across the microcirculation
Regulation of blood flow and volume exchange across the microcirculation Open
Oxygen delivery to cells is the basic prerequisite of life. Within the human body, an ingenious oxygen delivery system, comprising steps of convection and diffusion from the upper airways via the lungs and the cardiovascular system to the …
View article: Sevoflurane mitigates shedding of hyaluronan from the coronary endothelium, also during ischemia/reperfusion: an ex vivo animal study
Sevoflurane mitigates shedding of hyaluronan from the coronary endothelium, also during ischemia/reperfusion: an ex vivo animal study Open
Glycosaminoglycan hyaluronan (HA), a major constituent of the endothelial glycocalyx, helps to maintain vascular integrity. Preconditioning the heart with volatile anesthetic agents protects against ischemia/reperfusion injury. We investig…
View article: Gender-Specific Differences in Low-Dose Haloperidol Response for Prevention of Postoperative Nausea and Vomiting: A Register-Based Cohort Study
Gender-Specific Differences in Low-Dose Haloperidol Response for Prevention of Postoperative Nausea and Vomiting: A Register-Based Cohort Study Open
This study suggests that low-dose haloperidol has an antiemetic effect in male patients but has no effect in female patients. A confirmation of the gender-specific effects we have observed in this register-based cohort study might have maj…
View article: Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases
Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases Open
The endothelial glycocalyx has a profound influence at the vascular wall on the transmission of shear stress, on the maintenance of a selective permeability barrier and a low hydraulic conductivity, and on attenuating firm adhesion of bloo…