Daniel Chew
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View article: How can innovative design strategies in biotechnology address biocompatibility and signal processing challenges in next-generation bioelectronic interfaces?
How can innovative design strategies in biotechnology address biocompatibility and signal processing challenges in next-generation bioelectronic interfaces? Open
Biotechnology, with its vast potential, is poised to revolutionize fields ranging from medicine and healthcare to environmental sensing. Central to this revolution are bio-interfaces, which include both electrical and non-electrical interv…
View article: Functional Electrochemistry: On-Nerve Assessment of Electrode Materials for Electrochemistry and Functional Neurostimulation
Functional Electrochemistry: On-Nerve Assessment of Electrode Materials for Electrochemistry and Functional Neurostimulation Open
Emerging therapies in bioelectronic medicine highlight the need for deeper understanding of electrode material performance in the context of tissue stimulation. Electrochemical properties are characterized on the benchtop, facilitating sta…
View article: Improved OFDM Signal Cancellation through Window Estimation
Improved OFDM Signal Cancellation through Window Estimation Open
The ability to cancel an OFDM signal is important to many wireless communication systems including Power-Domain Non-orthogonal Multiple Access (PD-NOMA), Rate-Splitting Multiple Access (RSMA), and spectrum underlay for dynamic spectrum acc…
View article: How do we overcome the current limitations of bioelectronic sensors used in healthcare and medicine?
How do we overcome the current limitations of bioelectronic sensors used in healthcare and medicine? Open
There are several concerns with the use of bioelectronic sensors for healthcare applications, including: 1. Implantation: Bioelectronic sensors that are implanted into the body can cause discomfort, infection, and scarring, and they can al…
View article: Splenic arterial neurovascular bundle stimulation in esophagectomy: A feasibility and safety prospective cohort study
Splenic arterial neurovascular bundle stimulation in esophagectomy: A feasibility and safety prospective cohort study Open
Introduction The autonomic nervous system is a key regulator of inflammation. Electrical stimulation of the vagus nerve has been shown to have some preclinical efficacy. However, only a few clinical studies have been reported to treat infl…
View article: Acute effects of insulin and insulin‐induced hypoglycaemia on carotid body chemoreceptor activity and cardiorespiratory responses in dogs
Acute effects of insulin and insulin‐induced hypoglycaemia on carotid body chemoreceptor activity and cardiorespiratory responses in dogs Open
The carotid body chemoreceptors (CBC) play an important role in the adaptive counter‐regulatory response to hypoglycaemia by evoking the CBC‐mediated sympathetic neuronal system to restore normoglycaemia. Ex vivo studies have shown varied …
View article: Persistent Weak Interferer Detection in WiFi Networks: A Deep Learning Based Approach
Persistent Weak Interferer Detection in WiFi Networks: A Deep Learning Based Approach Open
In this paper, we explore the use of multiple deep learning techniques to detect weak interference in WiFi networks. Given the low interference signal levels involved, this scenario tends to be difficult to detect. However, even signal-to-…
View article: Covert Communications through Imperfect Cancellation
Covert Communications through Imperfect Cancellation Open
We propose a method for covert communications using an IEEE 802.11 OFDM/QAM packet as a carrier. We show how to hide the covert message so that the transmitted signal does not violate the spectral mask specified by the standard, and we det…
View article: Index
Index Open
Back-propagation 179, 181 Backup channel 241 Band plan 2-3, 7, 32, 55, 57, 293 Batch size 177 Baum-Welch algorithm 188 Binary hypothesis test 120 false negative 121-122 false positive 121-122 Blind sensing 242-243 Boltzmann policy 195 c Ca…
View article: Human-relevant near-organ neuromodulation of the immune system via the splenic nerve
Human-relevant near-organ neuromodulation of the immune system via the splenic nerve Open
Significance Bioelectronic modulation of the autonomic nervous system innervating the spleen represents a new therapeutic avenue. Studies in rodents suffer from the limitation that stimulation parameters and anatomy are not directly applic…
View article: Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs
Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs Open
Neuromodulation of the immune system has been proposed as a novel therapeutic strategy for the treatment of inflammatory conditions. We recently demonstrated that stimulation of near-organ autonomic nerves to the spleen can be harnessed to…
View article: Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation
Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation Open
View article: Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves
Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves Open
Neuromodulation is a new therapeutic pathway to treat inflammatory conditions by modulating the electrical signalling pattern of the autonomic connections to the spleen. However, targeting this sub-division of the nervous system presents s…
View article: Printable microscale interfaces for long-term peripheral nerve mapping and precision control
Printable microscale interfaces for long-term peripheral nerve mapping and precision control Open
The nascent field of bioelectronic medicine seeks to decode and modulate peripheral nervous system signals to obtain therapeutic control of targeted end organs and effectors. Current approaches rely heavily on electrode-based devices, but …
View article: Feasibility of kilohertz frequency alternating current neuromodulation of carotid sinus nerve activity in the pig
Feasibility of kilohertz frequency alternating current neuromodulation of carotid sinus nerve activity in the pig Open
Recent research supports that over-activation of the carotid body plays a key role in metabolic diseases like type 2 diabetes. Supressing carotid body signalling through carotid sinus nerve (CSN) modulation may offer a therapeutic approach…
View article: Printable microscale interfaces for long-term peripheral nerve mapping and precision control
Printable microscale interfaces for long-term peripheral nerve mapping and precision control Open
The nascent field of bioelectronic medicine seeks to decode and modulate peripheral nervous system signals to obtain therapeutic control of targeted end organs and effectors. Current approaches rely heavily on electrode-based devices, but …
View article: Imaging fast neural traffic at fascicular level with electrical impedance tomography: proof of principle in rat sciatic nerve
Imaging fast neural traffic at fascicular level with electrical impedance tomography: proof of principle in rat sciatic nerve Open
The method presented here is a potential solution for imaging activity within peripheral nerves with high spatial accuracy. It also provides a basis for imaging and selective neuromodulation to be incorporated in a single implantable non-p…
View article: Stimulation of peripheral nerves using conductive hydrogel electrodes
Stimulation of peripheral nerves using conductive hydrogel electrodes Open
Nerve block via electrical stimulation of nerves requires a device capable of transferring large amounts of charge across the neural interface on chronic time scales. Current metal electrode designs are limited in their ability to safely a…
View article: Conductive Hydrogel Electrodes for Delivery of Long-Term High Frequency Pulses
Conductive Hydrogel Electrodes for Delivery of Long-Term High Frequency Pulses Open
Nerve block waveforms require the passage of large amounts of electrical energy at the neural interface for extended periods of time. It is desirable that such waveforms be applied chronically, consistent with the treatment of protracted i…
View article: Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes
Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes Open
KHFAC modulation of the CSN improves metabolic control in rat models of type 2 diabetes. These positive outcomes have significant translational potential as a novel therapeutic modality for the purpose of treating metabolic diseases in hum…
View article: Carbon fiber on polyimide ultra-microelectrodes
Carbon fiber on polyimide ultra-microelectrodes Open
Our innovations in fabrication technique pave the way for further miniaturization of carbon fiber ultra-microelectrode arrays. We believe these advances to be key steps to enable a shift from labor intensive, manual assembly to a more auto…
View article: Carbon Fiber on Polyimide Ultra-Microelectrodes
Carbon Fiber on Polyimide Ultra-Microelectrodes Open
Most preparations for making neural recordings degrade over time and eventually fail due to insertion trauma and reactive tissue response. The magnitudes of these responses are thought to be related to the electrode size (specifically, the…
View article: Expression of an Activated Integrin Promotes Long-Distance Sensory Axon Regeneration in the Spinal Cord
Expression of an Activated Integrin Promotes Long-Distance Sensory Axon Regeneration in the Spinal Cord Open
UNLABELLED: After CNS injury, axon regeneration is blocked by an inhibitory environment consisting of the highly upregulated tenascin-C and chondroitin sulfate proteoglycans (CSPGs). Tenascin-C promotes growth of axons if they express a te…
View article: Chronic multichannel neural recordings from soft regenerative microchannel electrodes during gait
Chronic multichannel neural recordings from soft regenerative microchannel electrodes during gait Open
Reliably interfacing a nerve with an electrode array is one of the approaches to restore motor and sensory functions after an injury to the peripheral nerve. Accomplishing this with current technologies is challenging as the electrode-neur…
View article: A new method for spike extraction using velocity selective recording demonstrated with physiological ENG in Rat
A new method for spike extraction using velocity selective recording demonstrated with physiological ENG in Rat Open
View article: MP8-15 ELECTRICAL STIMULATION OF THE SPINAL DORSAL ROOT INHIBITS REFLEX BLADDER CONTRACTION AND EXTERNAL URETHRA SPHINCTER ACTIVITY: IS THIS HOW SACRAL NEUROMODULATION WORKS?
MP8-15 ELECTRICAL STIMULATION OF THE SPINAL DORSAL ROOT INHIBITS REFLEX BLADDER CONTRACTION AND EXTERNAL URETHRA SPHINCTER ACTIVITY: IS THIS HOW SACRAL NEUROMODULATION WORKS? Open
You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Basic Research I1 Apr 2015MP8-15 ELECTRICAL STIMULATION OF THE SPINAL DORSAL ROOT INHIBITS REFLEX BLADDER CONTRACTION AND EXTERNAL URETHRA SPHINCTER ACTIVITY: IS THI…
View article: Retinal Glia Promote Dorsal Root Ganglion Axon Regeneration
Retinal Glia Promote Dorsal Root Ganglion Axon Regeneration Open
Axon regeneration in the adult central nervous system (CNS) is limited by several factors including a lack of neurotrophic support. Recent studies have shown that glia from the adult rat CNS, specifically retinal astrocytes and Müller glia…