Daniel Coman
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View article: [<sup>18</sup>F]SynVesT-1 PET Detects SV2A Changes in the Spinal Cord and Brain of Rats with Spinal Cord Injury
[<sup>18</sup>F]SynVesT-1 PET Detects SV2A Changes in the Spinal Cord and Brain of Rats with Spinal Cord Injury Open
Traumatic spinal cord injury (SCI) is a devastating neurologic condition lacking effective prognostic and treatment methods. PET imaging of synaptic vesicle glycoprotein 2A (SV2A) has been used in measuring synapse changes. We explore the …
View article: Intranasal Leukemia Inhibitory Factor as a late-stage treatment for delayed white matter damage in concussive head injury
Intranasal Leukemia Inhibitory Factor as a late-stage treatment for delayed white matter damage in concussive head injury Open
Leukemia Inhibitory Factor (LIF) is an injury-induced cytokine that peaks 48 hours after a traumatic brain injury (TBI). Juvenile LIF haplodeficient mice exhibit desynchronized glial responses, increased neurodegeneration, decreased axonal…
View article: Molecular MRI of T-cell immune response to cryoablation in immunologically hot vs. cold hepatocellular carcinoma
Molecular MRI of T-cell immune response to cryoablation in immunologically hot vs. cold hepatocellular carcinoma Open
This study successfully established reliable MR-based molecular imaging tools to visualize CD8+ anti-tumor specific T-cell infiltration following partial cryoablation (pCryo) in murine tumor models. The study's significance lies in advanci…
View article: Cysteine depletion triggers adipose tissue thermogenesis and weight-loss
Cysteine depletion triggers adipose tissue thermogenesis and weight-loss Open
Dietary interventions such as caloric restriction (CR) 1 and methionine restriction 2 that prolong lifespan induce the ‘browning’ of white adipose tissue (WAT), an adaptive metabolic response that increases heat production to maintain heal…
View article: mTOR inhibition enhances synaptic and mitochondrial function in Alzheimer’s disease in an APOE genotype-dependent manner
mTOR inhibition enhances synaptic and mitochondrial function in Alzheimer’s disease in an APOE genotype-dependent manner Open
Apolipoprotein ε4 (APOE4) carriers develop brain metabolic dysfunctions decades before the onset of Alzheimer’s disease (AD). A goal of the study is to identify if rapamycin, an inhibitor for the mammalian target of rapamycin (mTOR) inhibi…
View article: Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8<sup>+</sup> T-Cell Infiltration in Murine Hepatocellular Carcinoma
Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8<sup>+</sup> T-Cell Infiltration in Murine Hepatocellular Carcinoma Open
Background Image-guided tumor ablation is the first-line therapy for early-stage hepatocellular carcinoma (HCC), with ongoing investigations into its combination with immunotherapies. Matrix metalloproteinase (MMP) inhibition demonstrates …
View article: Transmembrane pH gradient imaging in rodent glioma models
Transmembrane pH gradient imaging in rodent glioma models Open
A unique feature of the tumor microenvironment is extracellular acidosis in relation to intracellular milieu. Metabolic reprogramming in tumors results in overproduction of H + ions (and lactate), which are extruded from the cells to suppo…
View article: White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology
White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology Open
Introduction An inactivating mutation in the histidine decarboxylase gene ( Hdc ) has been identified as a rare but high-penetrance genetic cause of Tourette syndrome (TS). TS is a neurodevelopmental syndrome characterized by recurrent mot…
View article: CCDC 2024208: Experimental Crystal Structure Determination
CCDC 2024208: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Preimplantation factor modulates oligodendrocytes by H19-induced demethylation of NCOR2
Preimplantation factor modulates oligodendrocytes by H19-induced demethylation of NCOR2 Open
Failed or altered gliogenesis is a major characteristic of diffuse white matter injury in survivors of premature birth. The developmentally regulated long noncoding RNA (lncRNA) H19 inhibits S-adenosylhomocysteine hydrolase (SAHH) and cont…
View article: Imaging Hallmarks of the Tumor Microenvironment in Glioblastoma Progression
Imaging Hallmarks of the Tumor Microenvironment in Glioblastoma Progression Open
Glioblastoma progression involves multifaceted changes in vascularity, cellularity, and metabolism. Capturing such complexities of the tumor niche, from the tumor core to the periphery, by magnetic resonance imaging (MRI) and spectroscopic…
View article: Diffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele
Diffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele Open
Neural tube defects are a common congenital anomaly involving incomplete closure of the spinal cord. Myelomeningocele (MMC) is a severe form in which there is complete exposure of neural tissue with a lack of skin, soft tissue, or bony cov…
View article: Comparative Study of Specific Loss Power and Transverse Relaxivity of Spinel Ferrite Nanoensembles Coated With Chitosan and Polyethylene Glycol
Comparative Study of Specific Loss Power and Transverse Relaxivity of Spinel Ferrite Nanoensembles Coated With Chitosan and Polyethylene Glycol Open
We synthesized spinel ferrite nanoensembles (MnFe 2 O 4 , CoFe 2 O 4 , and Fe 3 O 4 ) using the chemical co-precipitation method and characterized their physical, chemical, and magnetic properties by X-ray diffraction (XRD), transmission e…
View article: Imaging the transmembrane and transendothelial sodium gradients in gliomas
Imaging the transmembrane and transendothelial sodium gradients in gliomas Open
Under normal conditions, high sodium (Na + ) in extracellular (Na + e ) and blood (Na + b ) compartments and low Na + in intracellular milieu (Na + i ) produce strong transmembrane (ΔNa + mem ) and weak transendothelial (ΔNa + end ) gradie…
View article: Imaging the Transmembrane and Transendothelial Sodium Gradients in Gliomas
Imaging the Transmembrane and Transendothelial Sodium Gradients in Gliomas Open
High sodium (Na + ) in extracellular (Na + e ) and blood (Na + b ) compartments and low Na + in intracellular milieu (Na + i ) produce strong transmembrane (ΔNa + mem ) and weak transendothelial (ΔNa + end ) gradients respectively, which r…
View article: Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy
Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy Open
Tumor targeting studies using metallic nanoparticles (NPs) have shown that the enhanced permeability and retention effect may not be sufficient to deliver the amount of intratumoral and intracellular NPs needed for effective in vivo radios…
View article: Molecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy?
Molecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy? Open
Background The immuno-metabolic interplay has gained interest for determining and targeting immunosuppressive tumor micro-environments that remain a barrier to current immuno-oncologic therapies in hepatocellular carcinoma. Purpose To deve…
View article: Extracellular pH mapping of liver cancer on a clinical 3T MRI scanner
Extracellular pH mapping of liver cancer on a clinical 3T MRI scanner Open
Purpose To demonstrate feasibility of developing a noninvasive extracellular pH (pH e ) mapping method on a clinical MRI scanner for molecular imaging of liver cancer. Methods In vivo pH e mapping has been demonstrated on preclinical scann…