Daniel Corey
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View article: Data from Therapeutic Targeting of TIM-4-L with Engineered T Cells for Acute Myeloid Leukemia
Data from Therapeutic Targeting of TIM-4-L with Engineered T Cells for Acute Myeloid Leukemia Open
Purpose:Disruption of lipid bilayer asymmetry is a common feature observed in cancer cells and offers novel routes for therapeutic targeting. We used the natural immune receptor TIM-4 to interrogate for loss of plasma membrane phospholipid…
View article: Data from Therapeutic Targeting of TIM-4-L with Engineered T Cells for Acute Myeloid Leukemia
Data from Therapeutic Targeting of TIM-4-L with Engineered T Cells for Acute Myeloid Leukemia Open
Purpose:Disruption of lipid bilayer asymmetry is a common feature observed in cancer cells and offers novel routes for therapeutic targeting. We used the natural immune receptor TIM-4 to interrogate for loss of plasma membrane phospholipid…
View article: Supplementary Data 1 from Therapeutic Targeting of TIM-4-L with Engineered T Cells for Acute Myeloid Leukemia
Supplementary Data 1 from Therapeutic Targeting of TIM-4-L with Engineered T Cells for Acute Myeloid Leukemia Open
Supplementary materials and methods, tables, and figures
View article: Supplementary Data 1 from Therapeutic Targeting of TIM-4-L with Engineered T Cells for Acute Myeloid Leukemia
Supplementary Data 1 from Therapeutic Targeting of TIM-4-L with Engineered T Cells for Acute Myeloid Leukemia Open
Supplementary materials and methods, tables, and figures
View article: Therapeutic Targeting of TIM-4-L With Engineered T Cells for Acute Myeloid Leukemia
Therapeutic Targeting of TIM-4-L With Engineered T Cells for Acute Myeloid Leukemia Open
Disruption of the lipid asymmetric bilayer is a common feature observed in cancer cells. We utilized the natural immune receptor TIM-4 to interrogate for loss of plasma membrane phospholipid polarity in primary acute myelogenous leukemia (…
View article: Chimeric TIM-4 receptor-modified T cells targeting phosphatidylserine mediates both cytotoxic anti-tumor responses and phagocytic uptake of tumor-associated antigen for T cell cross-presentation
Chimeric TIM-4 receptor-modified T cells targeting phosphatidylserine mediates both cytotoxic anti-tumor responses and phagocytic uptake of tumor-associated antigen for T cell cross-presentation Open
To leverage complementary mechanisms for cancer cell removal, we developed a novel cell engineering and therapeutic strategy co-opting phagocytic clearance and antigen presentation activity into T cells. We engineered a chimeric engulfment…
View article: Supplementary Figure 1| Clonal Composition of ActinCreER2Rainbow Blood Vessels 180 and 270 days after Tamoxifen Administration from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape
Supplementary Figure 1| Clonal Composition of ActinCreER2Rainbow Blood Vessels 180 and 270 days after Tamoxifen Administration from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape Open
Clonal analysis results from 20 representative blood vessels 180 and 270 days after tamoxifen exposure show a uniform distribution in clonality within endothelium over the time period. We employed a Chi-squared test to evaluate the null hy…
View article: Supplementary Table 1 from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape
Supplementary Table 1 from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape Open
Normalized Gene Expression Values from FACS-isolated Lin- FSC low, CD144+ CD31+ clones.
View article: Supplementary Table 1 from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape
Supplementary Table 1 from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape Open
Normalized Gene Expression Values from FACS-isolated Lin- FSC low, CD144+ CD31+ clones.
View article: Supplemental figure legends from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape
Supplemental figure legends from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape Open
Supplemental figure legends
View article: Supplementary Figure 2| Circulating Hematopoietic Cells do not contribute to tumor blood vessels. from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape
Supplementary Figure 2| Circulating Hematopoietic Cells do not contribute to tumor blood vessels. from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape Open
Flow cytometry plots from wild-type mice reconstituted with cyan-fluorescent-protein hematopoietic stem cells CFP-HSCs showing the absence of CFP-HSC derived cells in blood vessels. (a) Flow cytometry plots showing gating of B16 tumors aft…
View article: Supplementary Figure 2| Circulating Hematopoietic Cells do not contribute to tumor blood vessels. from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape
Supplementary Figure 2| Circulating Hematopoietic Cells do not contribute to tumor blood vessels. from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape Open
Flow cytometry plots from wild-type mice reconstituted with cyan-fluorescent-protein hematopoietic stem cells CFP-HSCs showing the absence of CFP-HSC derived cells in blood vessels. (a) Flow cytometry plots showing gating of B16 tumors aft…
View article: Supplemental figure legends from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape
Supplemental figure legends from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape Open
Supplemental figure legends
View article: Data from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape
Data from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape Open
Although tumor blood vessels have been a major therapeutic target for cancer chemotherapy, little is known regarding the stepwise development of the tumor microenvironment. Here, we use a multicolor Cre-dependent marker system to trace clo…
View article: Data from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape
Data from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape Open
Although tumor blood vessels have been a major therapeutic target for cancer chemotherapy, little is known regarding the stepwise development of the tumor microenvironment. Here, we use a multicolor Cre-dependent marker system to trace clo…
View article: Supplementary Figure 1| Clonal Composition of ActinCreER2Rainbow Blood Vessels 180 and 270 days after Tamoxifen Administration from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape
Supplementary Figure 1| Clonal Composition of ActinCreER2Rainbow Blood Vessels 180 and 270 days after Tamoxifen Administration from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape Open
Clonal analysis results from 20 representative blood vessels 180 and 270 days after tamoxifen exposure show a uniform distribution in clonality within endothelium over the time period. We employed a Chi-squared test to evaluate the null hy…
View article: 378 Chimeric engulfment receptor (CER) T cells with a TLR2 domain synergize with an EGFR inhibitor to target NSCLC cells in vitro and demonstrate APC-like function
378 Chimeric engulfment receptor (CER) T cells with a TLR2 domain synergize with an EGFR inhibitor to target NSCLC cells in vitro and demonstrate APC-like function Open
Background A barrier to successful adoptive cell therapy for solid tumors is target antigen heterogeneity and antigen escape. Activated T cells, including CAR T cells, have limited innate antigen capture/presentation capabilities.1 We engi…
View article: Novel engineered chimeric engulfment receptors trigger T-cell effector functions against SIV infected CD4+ T cells
Novel engineered chimeric engulfment receptors trigger T-cell effector functions against SIV infected CD4+ T cells Open
Adoptive therapy with genetically engineered T cells offers potential for infectious disease treatment in immunocompromised persons. HIV/simian immunodeficiency virus (SIV) infected cells express phosphatidylserine (PS) early post-infectio…
View article: 207 Enhanced antigen capture, antigen-presenting cell (APC)-like function, and cytotoxic responses with chimeric engulfment receptor (CER) T cells
207 Enhanced antigen capture, antigen-presenting cell (APC)-like function, and cytotoxic responses with chimeric engulfment receptor (CER) T cells Open
Background Activated T cells have limited antigen presenting capability due to inefficient capture.1 This process can be enhanced through novel chimeric engulfment receptors (CERs) expressing a human Tim-4 phagocyte receptor that recognize…
View article: Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition
Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition Open
Immune responses to infectious agents are initiated when a pathogen or its components bind to pattern recognition receptors (PRRs). PRR binding sets off a cascade of events that activates immune responses. We now show that, in addition to …
View article: Evolutionary Origin of the Mammalian Hematopoietic System Found in a Colonial Chordate
Evolutionary Origin of the Mammalian Hematopoietic System Found in a Colonial Chordate Open
Summary Hematopoiesis is an essential process that evolved in multicellular animals. At the heart of this process are hematopoietic stem cells (HSCs), which are multipotent, self-renewing and generate the entire repertoire of blood and imm…
View article: PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity Open
Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor that is upregulated on activated T cells for the induction of immune tolerance. Tumour cells frequently overexpress the ligand for PD-1, programmed cell death ligand 1…
View article: Developmental cell death programs license cytotoxic cells to eliminate histocompatible partners
Developmental cell death programs license cytotoxic cells to eliminate histocompatible partners Open
Significance The colonial tunicate, Botryllus schlosseri , undergoes natural self–nonself recognition that results in formation of a chimera. Following fusion, one chimeric partner is often eliminated in a process of allogeneic resorption,…
View article: Developmental Regulated Cell Death Programs Account for Colony Elimination and Unstable Mixed-Chimerism in B. Schlosseri: Implications for Allogeneic Graft Survival
Developmental Regulated Cell Death Programs Account for Colony Elimination and Unstable Mixed-Chimerism in B. Schlosseri: Implications for Allogeneic Graft Survival Open
To understand mechanisms fundamental to the maintenance of allogeneic mixed-chimerism we conducted a detailed anatomic and transcriptional analysis of B. schlosseri natural chimeras, a colonial protochordate that undergoes a genetically co…
View article: Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape
Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape Open
Although tumor blood vessels have been a major therapeutic target for cancer chemotherapy, little is known regarding the stepwise development of the tumor microenvironment. Here, we use a multicolor Cre-dependent marker system to trace clo…
View article: Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway
Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway Open
The endothelial receptor tyrosine kinase (RTK) Tie1 was discovered over 20 years ago, yet its precise function and mode of action remain enigmatic. To shed light on Tie1's role in endothelial cell biology, we investigated a potential threo…