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View article: Optimization of surgical fixation in cervical spine fractures using advanced imaging techniques: a systematic review of functional and neurological outcomes
Optimization of surgical fixation in cervical spine fractures using advanced imaging techniques: a systematic review of functional and neurological outcomes Open
Cervical spine fractures are high-stakes injuries with substantial risks of permanent neurological damage and disability. Traditional imaging methods, including plain radiographs and fluoroscopy, are limited by low sensitivity and spatial …
View article: Low Parental Participation in a Randomised Clinical Trial of Video Tutorials: A Qualitative Study
Low Parental Participation in a Randomised Clinical Trial of Video Tutorials: A Qualitative Study Open
Aim Parents calling a Danish out‐of‐hours nonurgent medical helpline were invited to a trial comparing video tutorials on managing children's acute illnesses with telephone triage by health professionals. Participants allocated to videos w…
View article: Bypass of Blocking Lesions by RNAPII Impairs the Transcriptional DNA Damage Response
Bypass of Blocking Lesions by RNAPII Impairs the Transcriptional DNA Damage Response Open
Ultraviolet (UV) irradiation and platinum-based drugs generate bulky DNA lesions that impede transcription elongation by RNA Polymerase II (RNAPII). This transcriptional block triggers a coordinated stress response involving transcription-…
View article: Parents’ Motivations for Calling an Out-of-Hours Helpline: Qualitative Study
Parents’ Motivations for Calling an Out-of-Hours Helpline: Qualitative Study Open
Background Young children often get sick, and although they usually do not need treatment, it can be distressing for parents and lead to a high rate of urgent health care use. As the demand for out-of-hours services grows, understanding pa…
View article: Targeted radioligand therapy: physics and biology, internal dosimetry and other practical aspects during <sup>177</sup>Lu/<sup>225</sup>Ac treatment in neuroendocrine tumors and metastatic prostate cancer
Targeted radioligand therapy: physics and biology, internal dosimetry and other practical aspects during <sup>177</sup>Lu/<sup>225</sup>Ac treatment in neuroendocrine tumors and metastatic prostate cancer Open
Radioligand therapy (RLT) has garnered significant attention due to the recent emergence of innovative and effective theranostic agents, which showed promising therapeutic and prognostic results in various cancers. Moreover, understanding …
View article: Vesicocervical fistula: a case report
Vesicocervical fistula: a case report Open
We present a case report of a vesicocervical fistula in a 70-year-old female with history of caesarean section forty-five years prior to clinical presentation, she presented referring continuous vaginal urinary incontinence of a couple of …
View article: Parents’ Motivations for Calling an Out-of-Hours Helpline: Qualitative Study (Preprint)
Parents’ Motivations for Calling an Out-of-Hours Helpline: Qualitative Study (Preprint) Open
BACKGROUND Young children often get sick, and although they usually do not need treatment, it can be distressing for parents and lead to a high rate of urgent health care use. As the demand for out-of-hours services grows, understanding p…
View article: <i>Stentor stipatus</i> , a new unicellular species, demonstrates novel phototaxis and habituation
<i>Stentor stipatus</i> , a new unicellular species, demonstrates novel phototaxis and habituation Open
Background Stentor , the genus of large trumpet-shaped ciliates, is well-known for its complex morphology and striking behaviors. Members of this genus are distributed throughout the world in a wide and diverse pool of freshwater ecosystem…
View article: Testis tissue cryopreservation may be considered in boys with cryptorchidism
Testis tissue cryopreservation may be considered in boys with cryptorchidism Open
This study assessed the feasibility of testis tissue cryopreservation (TTC) for fertility preservation in prepubescent boys with cryptorchidism. From January 2014 to December 2022, the University Hospital of Copenhagen (Rigshospitalet, Cop…
View article: Host RNA Expression Signatures in Young Infants with Urinary Tract Infection: A Prospective Study
Host RNA Expression Signatures in Young Infants with Urinary Tract Infection: A Prospective Study Open
Early diagnosis of infections in young infants remains a clinical challenge. Young infants are particularly vulnerable to infection, and it is often difficult to clinically distinguish between bacterial and viral infections. Urinary tract …
View article: Multi-strain probiotics during pregnancy in women with obesity influence infant gut microbiome development: results from a randomized, double-blind placebo-controlled study
Multi-strain probiotics during pregnancy in women with obesity influence infant gut microbiome development: results from a randomized, double-blind placebo-controlled study Open
Probiotics have been described to influence host health and prevent the risk of obesity by gut microbiome (GM) modulation. In a randomized double-blinded placebo-controlled feasibility study, we investigated whether Vivomixx® multi-strain …
View article: Anogenital distance in a cohort of 169 infant boys with uni- or bilateral cryptorchidism including 18 boys with vanishing testes
Anogenital distance in a cohort of 169 infant boys with uni- or bilateral cryptorchidism including 18 boys with vanishing testes Open
STUDY QUESTION Do different boys with different types of cryptorchidism exhibit different anogenital distances (AGDs)? SUMMARY ANSWER Length of AGD seemed to differ in different groups of patients with cryptorchidism. WHAT IS KNOWN ALREADY…
View article: The fate of germ cells in cryptorchid testis
The fate of germ cells in cryptorchid testis Open
Cryptorchidism in males constitutes a notable risk factor for both infertility and testicular cancer. Infertility in adulthood is closely linked to the germ cell status in childhood. Furthermore, the significance of germ cell status is imp…
View article: Video Tutorials to Empower Caregivers of Ill Children and Reduce Health Care Utilization
Video Tutorials to Empower Caregivers of Ill Children and Reduce Health Care Utilization Open
Importance Young children often fall ill, leading to concern among their caregivers and urgent contact with health care services. Objective To assess the effectiveness and safety of video tutorials to empower caregivers in caring for acute…
View article: The Inhibin-B Level at Orchidopexy and Follow-up of 280 Boys With Non-syndromic Unilateral Cryptorchid Testes
The Inhibin-B Level at Orchidopexy and Follow-up of 280 Boys With Non-syndromic Unilateral Cryptorchid Testes Open
Orchidopexy benefits the fertility potential. About 10% of boys with unilateral non-syndromic cryptorchidism may have a bilateral testicular disease reducing their fertility potential. Insufficient gonadotropin stimulation may possibly be …
View article: Individualised versus standard duration of antibiotic therapy in children with acute uncomplicated febrile urinary tract infection: a study protocol and statistical analysis plan for a multicentre randomised clinical trial
Individualised versus standard duration of antibiotic therapy in children with acute uncomplicated febrile urinary tract infection: a study protocol and statistical analysis plan for a multicentre randomised clinical trial Open
Introduction Febrile urinary tract infection is one of the most common bacterial infections in children. Currently, recommended antibiotic duration is 10 days. However, recent evidence suggests that 90%–95% of children with febrile urinary…
View article: Development of video tutorials to help parents manage children with acute illnesses using a modified Delphi method
Development of video tutorials to help parents manage children with acute illnesses using a modified Delphi method Open
Aim Children often fall sick, which causes concern among parents. Online health information can be confusing and difficult to understand. We aimed to produce simple, informative video tutorials on the symptoms ill children present. Methods…
View article: Video triage of children with respiratory symptoms at a medical helpline is safe and feasible–a prospective quality improvement study
Video triage of children with respiratory symptoms at a medical helpline is safe and feasible–a prospective quality improvement study Open
Background Young children are among the most frequent patients at medical call centers, even though they are rarely severely ill. Respiratory tract symptoms are among the most prevalent reasons for contact in pediatric calls. Triage of chi…
View article: Organotypic Culture of Testicular Tissue from Infant Boys with Cryptorchidism
Organotypic Culture of Testicular Tissue from Infant Boys with Cryptorchidism Open
Organotypic culture of human fetal testis has achieved fertilization-competent spermatids followed by blastocysts development. This study focuses on whether the organotypic culture of testicular tissue from infant boys with cryptorchidism …
View article: P-468 Organotypic culture of testicular tissue from infant boys with cryptorchidism
P-468 Organotypic culture of testicular tissue from infant boys with cryptorchidism Open
Study question Can organotypic culture support the survival and maturation of germ cells and niche-related cells within testicular tissue from infant boys with cryptorchidism? Summary answer The testicular structure and the number of germ …
View article: 237 Introduction of video triage of children with respiratory symptoms at a medical helpline
237 Introduction of video triage of children with respiratory symptoms at a medical helpline Open
Background Calls regarding children make up the relatively largest proportion of contacts to medical call-centers, with calls often concerning respiratory symptoms. Triage of children without visual cues and through second-hand information…
View article: 289 Effects of informative videos to empower parents in handling acutely ill children: a randomized controlled trial
289 Effects of informative videos to empower parents in handling acutely ill children: a randomized controlled trial Open
Background Copenhagen Emergency Medical Services (CEMS), Denmark, serves the Capital Region and receives about 200,000 out-of-hours calls/year regarding children. About 40% are referred for further assessment at hospital, but less than two…
View article: “We can’t do without it”: Parent and call-handler experiences of video triage of children at a medical helpline
“We can’t do without it”: Parent and call-handler experiences of video triage of children at a medical helpline Open
Background Pediatric out-of-hours calls are common, as parents worry and seek reassurance and shared responsibility. Nevertheless, most children assessed in this context are not seriously ill. Conventional telephone triage lacks visual cue…
View article: Characterization and Survival of Human Infant Testicular Cells After Direct Xenotransplantation
Characterization and Survival of Human Infant Testicular Cells After Direct Xenotransplantation Open
Background Cryopreservation of prepubertal testicular tissue preserves spermatogonial stem cells (SSCs) that may be used to restore fertility in men at risk of infertility due to gonadotoxic treatments for either a malignant or non-maligna…
View article: Children with acute pyelonephritis need medical re‐evaluation when home‐treated with oral antibiotics
Children with acute pyelonephritis need medical re‐evaluation when home‐treated with oral antibiotics Open
Aim To investigate the efficacy and safety of home‐treatment with oral piv‐mecillinam or amoxicillin‐clavulanate in children with acute pyelonephritis. Methods Children aged over 6 months diagnosed with culture confirmed pyelonephritis at …