Daniel Duerschmied
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Amyloid‐beta (1–40) peptide is associated with systemic metabolic health Open
Background Amyloid‐beta 1–40 peptide (Aβ40) has recently emerged as a blood‐based biomarker of cardiovascular disease (CVD). However, whether plasma levels of Aβ40 are associated with metabolic traits in humans without established CVD rema…
View article: Albumin, urea‐to‐albumin ratio, or the albumin‐to‐creatinine ratio to predict outcomes in heart failure with mildly reduced ejection fraction
Albumin, urea‐to‐albumin ratio, or the albumin‐to‐creatinine ratio to predict outcomes in heart failure with mildly reduced ejection fraction Open
Background This study investigates the prognostic impact of albumin, the urea‐to‐albumin ratio ( UAR ), and albumin‐to‐creatinine ratio ( ACR ) in patients with heart failure with mildly reduced ejection fraction ( HFmrEF ), since hypoalbu…
View article: Platelet counts and prognosis in heart failure with mildly reduced ejection fraction: Results from a large-scaled registry
Platelet counts and prognosis in heart failure with mildly reduced ejection fraction: Results from a large-scaled registry Open
In patients hospitalized with HFmrEF, baseline platelet counts of <50/nL and 50- < 100/nL were independently associated with an increased risk of all-cause mortality at 30 months.
View article: ECG Markers of Positive Drug Challenge With Ajmaline in Patients With Brugada Syndrome
ECG Markers of Positive Drug Challenge With Ajmaline in Patients With Brugada Syndrome Open
Background Ajmaline challenge (AC) is used for diagnosing suspected Brugada syndrome (BS) in patients with unexplained syncope, survived cardiac arrest, or for family screening. Purpose To evaluate baseline ECG markers predicting a positiv…
Neutrophil extracellular traps and peptidylarginine deiminase 4–mediated inflammasome activation link diabetes to cardiorenal injury and heart failure Open
Background and Aims Diabetes is associated with increased risk of cardiovascular and renal disease. This study investigated the role of peptidylarginine deiminase 4 (PAD4), neutrophil extracellular traps (NETs), and inflammasome activation…
View article: Murine reticulated platelets generated during recovery from antibody-induced thrombocytopenia are functionally impaired and transcriptionally rewired
Murine reticulated platelets generated during recovery from antibody-induced thrombocytopenia are functionally impaired and transcriptionally rewired Open
Reticulated platelets (RP) are newly released, RNA-rich platelets that often increase during recovery from thrombocytopenia. Though considered hyperreactive compared to non-RP, their functional and molecular features under immune-mediated …
A transgenic mouse model for reticulated platelet detection reveals expansion after myocardial ischemia/reperfusion Open
Reticulated platelets are newly formed, RNA-rich platelets with heightened reactivity. Although elevated levels are observed after myocardial ischemia/reperfusion injury, their functional contributions to postischemic pathology remains poo…
View article: An interpretable machine learning algorithm enables dynamic 48-hour mortality prediction during an ICU stay
An interpretable machine learning algorithm enables dynamic 48-hour mortality prediction during an ICU stay Open
Backround Accurate short-term mortality prediction is essential for optimizing ICU management and improving patient outcomes. Many existing models rely on static data and do not reflect the dynamic progression of critical illness. This stu…
View article: Subkutaner Defibrillator (S-ICD)
Subkutaner Defibrillator (S-ICD) Open
Zusammenfassung Die Defibrillatortherapie muss leitlinienkonform erfolgen und zuverlässig vor dem plötzlichen Herztod schützen, während gleichzeitig alle Komplikationen minimiert werden. Der subkutane implantierbare Kardioverter-Defibrilla…
View article: Fibrin clot strength is associated with increased risk of major adverse cardiac events after TAVR
Fibrin clot strength is associated with increased risk of major adverse cardiac events after TAVR Open
Background Patients after transcatheter aortic valve replacement (TAVR) are at increased risk of both major adverse cardiac events (MACE), including ischemic and thrombotic complications, as well as significant bleeding. Given this delicat…
Treatment and associated outcomes of type 2 diabetes mellitus patients with a cardiovascular comorbidity and comparison with guideline recommendations: a German claims data analysis Open
The results from this claims database study provide important insights into real-world management of CV comorbidities in T2DM patients in Germany and underline that inconsistent guideline adherence is a major unmet challenge to healthcare …
View article: Changes in central and peripheral hemodynamic parameters during blood donation
Changes in central and peripheral hemodynamic parameters during blood donation Open
Background Blood donation is a common procedure, yet its acute effects on central and peripheral hemodynamics are not fully understood. This study aimed to systematically quantify immediate cardiovascular changes induced by whole blood don…
View article: Prognostic impact of left ventricular dilatation in heart failure with mildly reduced ejection fraction
Prognostic impact of left ventricular dilatation in heart failure with mildly reduced ejection fraction Open
In HFmrEF, LV dilatation independently predicts HF-related rehospitalization but not all-cause mortality.
View article: Prognostic impact of rheumatic diseases in patients with heart failure with mildly reduced ejection fraction
Prognostic impact of rheumatic diseases in patients with heart failure with mildly reduced ejection fraction Open
Background Emerging evidence suggests that inflammatory conditions and comorbidities have a prognostic impact on patients with heart failure with mildly reduced ejection fraction (HFmrEF) in particular. This study aims to investigate the i…
View article: Platelet Reactivity and Fibrin Clot-Strength as assessed by TEG in Patients with Atrial Fibrillation undergoing Percutaneous Coronary Intervention
Platelet Reactivity and Fibrin Clot-Strength as assessed by TEG in Patients with Atrial Fibrillation undergoing Percutaneous Coronary Intervention Open
Platelet reactivity (PR) in clopidogrel-treated patients undergoing percutaneous coronary syndrome (PCI) associates with ischemic and bleeding risk. The aim was to investigate the association of PR and global hemostasis with this risk in p…
View article: Consistency and Risk Stratification Performance of 4 Society for Cardiovascular Angiography and Interventions SHOCK Stage Definitions: A Retrospective Study
Consistency and Risk Stratification Performance of 4 Society for Cardiovascular Angiography and Interventions SHOCK Stage Definitions: A Retrospective Study Open
Background Cardiogenic shock (CS) is a critical condition associated with high mortality rates, making prompt diagnosis essential for timely interventions that may improve patient outcomes. The Society for Cardiovascular Angiography and In…
View article: Comparing Inflammatory Biomarkers in Cardiovascular Disease: Insights from the LURIC Study
Comparing Inflammatory Biomarkers in Cardiovascular Disease: Insights from the LURIC Study Open
Inflammatory biomarkers, including high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), and interleukin-6 (IL-6), have been associated with an increased risk of future cardiovascular events. While they provide valuable progn…
View article: Left Ventricular Ejection Fraction Predicts Outcomes in Different Subgroups of Patients Undergoing Coronary Angiography
Left Ventricular Ejection Fraction Predicts Outcomes in Different Subgroups of Patients Undergoing Coronary Angiography Open
Objectives: To evaluate the long-term prognostic value of left ventricular ejection fraction (LVEF) in consecutive patients undergoing invasive coronary angiography (CA). Background: LVEF is a key prognostic marker in cardiovascular diseas…
View article: Prognostic impact of uric acid levels in heart failure with mildly reduced ejection fraction: Insights from a large retrospective registry
Prognostic impact of uric acid levels in heart failure with mildly reduced ejection fraction: Insights from a large retrospective registry Open
Both elevated and low UA levels were associated with an increased risk of long-term all-cause mortality in patients with HFmrEF.
View article: Shifting landscapes: dynamic changes from pro- to anti-inflammatory leukocyte phenotype in myocardial ischemia/reperfusion injury
Shifting landscapes: dynamic changes from pro- to anti-inflammatory leukocyte phenotype in myocardial ischemia/reperfusion injury Open
Background The temporal and spatial dynamics of platelet–leukocyte complex (PLC) formation in myocardial ischemia reperfusion injury (I/R injury) are still ill defined. Aim To investigate the kinetics and spatial differences of platelet-mo…
View article: Time Course of Growth Differentiation Factor-15 levels in Post-Resuscitation-Shock after Out-of-hospital Cardiac Arrest
Time Course of Growth Differentiation Factor-15 levels in Post-Resuscitation-Shock after Out-of-hospital Cardiac Arrest Open
Background: Shock is a major contributor to the poor prognosis of patients after out-of-hospital cardiac arrest (OHCA). This study investigated whether serial levels of growth differentiation factor (GDF)-15 may serve as a marker for impai…
View article: The Prognostic Impact of Kidney Dysfunction in Unselected Patients Undergoing Coronary Angiography: In What Subgroups Does Kidney Dysfunction Matter?
The Prognostic Impact of Kidney Dysfunction in Unselected Patients Undergoing Coronary Angiography: In What Subgroups Does Kidney Dysfunction Matter? Open
Background/Objectives: In recent decades, shifting demographics and advancements in treating cardiovascular disease have altered the types of patients receiving coronary angiography (CA). However, data investigating the impact of kidney dy…
View article: A multi-color flow cytometric method for characterizing murine reticulated platelets using SYTO 13
A multi-color flow cytometric method for characterizing murine reticulated platelets using SYTO 13 Open
Reticulated platelets (RP) are immature platelets with heightened RNA content. An increased level of RP in the circulation is associated with various pathological conditions. In this study, we employed a novel flow cytometry approach for R…
View article: Obesity is associated with impaired long-term prognosis in patients undergoing coronary angiography: Results from a large-scaled single centre registry
Obesity is associated with impaired long-term prognosis in patients undergoing coronary angiography: Results from a large-scaled single centre registry Open
In patients undergoing CA, a BMI ≥35 kg/m2 was associated with the highest risk of HF-related rehospitalization at 36 months.
View article: Elective Generator Replacement of the Subcutaneous Implantable Defibrillator—Always a Simple Pit Stop?
Elective Generator Replacement of the Subcutaneous Implantable Defibrillator—Always a Simple Pit Stop? Open
Background and Aims The safety and efficacy of the subcutaneous implantable cardioverter‐defibrillator (S‐ICD) has been proven in various clinical trials. Data on device replacement strategies is scarce. This study aims to evaluate long‐te…