Daniel DiToro
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View article: IL-2–induced Stat3 Signaling is Critical for Effector Treg Cell Programming
IL-2–induced Stat3 Signaling is Critical for Effector Treg Cell Programming Open
Maintenance of immune homeostasis to the intestinal mictrobiota is dependent on a population of effector regulatory T (eTreg) cells that develop from microbiota-reactive induced (i)Treg cells. A cardinal feature of eTreg cells is their pro…
View article: T-B Collaboration in Autoimmunity, Infection, and Transplantation
T-B Collaboration in Autoimmunity, Infection, and Transplantation Open
We have attempted here to provide an up-to-date review of the collaboration between helper T cells and B cells in response to protein and glycoprotein antigens. This collaboration is essential as it not only protects from many pathogens bu…
View article: Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy
Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy Open
Kidney transplant recipients are at particular risk for developing tumors, many of which are now routinely treated with immune checkpoint inhibitors (ICIs); however, ICI therapy can precipitate transplant rejection. Here, we use TCR sequen…
View article: Emerging Complexity in CD4+T Lineage Programming and Its Implications in Colorectal Cancer
Emerging Complexity in CD4+T Lineage Programming and Its Implications in Colorectal Cancer Open
The intestinal immune system has the difficult task of protecting a large environmentally exposed single layer of epithelium from pathogens without allowing inappropriate inflammatory responses. Unmitigated inflammation drives multiple pat…
View article: Ruptured Suprasellar Dermoid Cyst Treated With Lumbar Drain to Prevent Postoperative Hydrocephalus: Case Report and Focused Review of Literature
Ruptured Suprasellar Dermoid Cyst Treated With Lumbar Drain to Prevent Postoperative Hydrocephalus: Case Report and Focused Review of Literature Open
Background: Ruptured intracranial dermoid cysts are extremely rare. Standard treatment consists of endonasal decompression or craniotomy with evacuation and copious irrigation of subarachnoid spaces to remove any disseminated cystic conten…
View article: Radiation-induced intracranial osteosarcoma of the anterior skull base after treatment of esthesioneuroblastoma
Radiation-induced intracranial osteosarcoma of the anterior skull base after treatment of esthesioneuroblastoma Open
Esthesioneuroblastoma (ENB) is an uncommon sinonasal cancer of the olfactory neuroepithelium that is typically treated with surgical resection followed by radiation therapy. Radiation-induced intracranial osteosarcoma of the skull base is …
View article: T <sub>H</sub> 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity
T <sub>H</sub> 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity Open
Ongoing classic IL-6 receptor signaling is required to maintain the T H 17 program, acting upstream of IL-23 to sustain RORγt expression.
View article: A novel in situ multiplex immunofluorescence panel for the assessment of tumor immunopathology and response to virotherapy in pediatric glioblastoma reveals a role for checkpoint protein inhibition
A novel in situ multiplex immunofluorescence panel for the assessment of tumor immunopathology and response to virotherapy in pediatric glioblastoma reveals a role for checkpoint protein inhibition Open
Immunotherapy with oncolytic herpes simplex virus-1 therapy offers an innovative, targeted, less-toxic approach for treating brain tumors. However, a major obstacle in maximizing oncolytic virotherapy is a lack of comprehensive understandi…
View article: Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells
Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells Open
(IL-)2 be or not to be? Immunological T follicular helper (T FH ) cells are a subpopulation of CD4 + T cells that support B cell antibody production and the establishment of B cell memory. By contrast, non-T FH cells orchestrate enhanced i…