Daniel Dufort
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View article: Extracellular vesicles as prospective biological indicators for midgestational placental complications in the mouse
Extracellular vesicles as prospective biological indicators for midgestational placental complications in the mouse Open
Background Placental dysfunction is often associated with reproductive complications such as preeclampsia, intrauterine growth restriction (IUGR), and preterm birth. Currently, the early diagnosis and intervention of these pathologies rema…
View article: An Artificial Intelligence-Based Model to Predict Pregnancy After Intrauterine Insemination: A Retrospective Analysis of 9501 Cycles
An Artificial Intelligence-Based Model to Predict Pregnancy After Intrauterine Insemination: A Retrospective Analysis of 9501 Cycles Open
Background/Objectives: Intrauterine insemination (IUI) is a common first-line approach in the treatment of numerous infertile couples, especially in cases of unexplained infertility. Its relatively low success rate, however, could benefit …
View article: Nodal and cripto-1: distinct functions regulate trophoblast specification in mouse pregnancy
Nodal and cripto-1: distinct functions regulate trophoblast specification in mouse pregnancy Open
Introduction Proper placentation is essential for fetal growth and development in mammals. Nodal signaling is essential to ensure proper embryo development and requires Cripto-1 as a co-receptor. Both factors have been shown to be expresse…
View article: Uterine Nodal expression supports maternal immunotolerance and establishment of the FOXP3+ regulatory T cell population during the preimplantation period
Uterine Nodal expression supports maternal immunotolerance and establishment of the FOXP3+ regulatory T cell population during the preimplantation period Open
Pregnancy success is dependent on the establishment of maternal tolerance during the preimplantation period. The immunosuppressive function of regulatory T cells is critical to limit inflammation arising from implantation of the semi-allog…
View article: Uterine WNTS modulates fibronectin binding activity required for blastocyst attachment through the WNT/CA2+ signaling pathway in mice
Uterine WNTS modulates fibronectin binding activity required for blastocyst attachment through the WNT/CA2+ signaling pathway in mice Open
Adhesion of the implanting blastocyst involves the interaction between integrin proteins expressed by trophoblast cells and components present in the basement membrane of the endometrial luminal epithelium. Although several factors regulat…
View article: Maternal Cripto is required for proper uterine decidualization and peri-implantation uterine remodeling
Maternal Cripto is required for proper uterine decidualization and peri-implantation uterine remodeling Open
Cripto encodes for a cell surface receptor whose role in embryonic development and stem cell maintenance has been studied. Cripto mRNA and protein have been detected in the human uterus at all stages of the menstrual cycle. To date, there …
View article: Nodal is required to maintain the uterine environment in an anti-inflammatory state during pregnancy†
Nodal is required to maintain the uterine environment in an anti-inflammatory state during pregnancy† Open
Preterm birth remains the major cause of perinatal mortality and morbidity worldwide, affecting up to 12% of pregnancies and accounting for ~75% of neonatal deaths. However, the mechanisms and causes that underlie it are still largely unkn…
View article: Regulation of porcupine-dependent Wnt signaling is essential for uterine development and function
Regulation of porcupine-dependent Wnt signaling is essential for uterine development and function Open
Six members of the Wnt family are expressed in the female reproductive tract. Their collective function ensures proper development of the uterus, preparing it for pregnancy during adulthood. Here, we take advantage of the fact that Porcn, …
View article: Porcupine-dependent Wnt activity within the uterine epithelium is essential for fertility
Porcupine-dependent Wnt activity within the uterine epithelium is essential for fertility Open
The secretion of mammalian Wnt ligands within the cell is dependent on the activity of Porcupine, a gene located on the X-chromosome that encodes for a membrane-bound O-acyl transferase. Here, we report that postnatal ablation of Porcupine…