Daniel E. Adkins
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View article: Mapping the genetic landscape across 14 psychiatric disorders
Mapping the genetic landscape across 14 psychiatric disorders Open
Psychiatric disorders display high levels of comorbidity and genetic overlap1,2, challenging current diagnostic boundaries. For disorders for which diagnostic separation has been most debated, such as schizophrenia and bipolar disorder3, g…
View article: Genome-wide association study of adolescent-onset depression
Genome-wide association study of adolescent-onset depression Open
Adolescent depression is a heritable psychiatric condition with rising global prevalence and severe long-term outcomes, yet its biological underpinnings remain poorly understood. We conducted the first genome-wide association study of adol…
View article: The Impact of Postgraduate Mentors on Undergraduate Researcher Gains
The Impact of Postgraduate Mentors on Undergraduate Researcher Gains Open
We found that specific attributes and behaviors of postgraduate mentors are integral to students' undergraduate research experiences. This suggests that analysts and practitioners treat postgraduate mentorship as an essential part of …
View article: Racialized Health Inequities: Quantifying Socioeconomic and Stress Pathways Using Moderated Mediation
Racialized Health Inequities: Quantifying Socioeconomic and Stress Pathways Using Moderated Mediation Open
Racism drives population health inequities by shaping the unequal distribution of key social determinants of health, such as socioeconomic resources and exposure to stressors. Research on interrelationships among race, socioeconomic resour…
View article: COGNITIVE IMPAIRMENT IN VIETNAMESE OLDER ADULTS: EFFECTS OF LIVING ARRANGEMENTS AND FAMILIAL SUPPORT
COGNITIVE IMPAIRMENT IN VIETNAMESE OLDER ADULTS: EFFECTS OF LIVING ARRANGEMENTS AND FAMILIAL SUPPORT Open
Living alone has emerged as a prominent modifiable risk factor for cognitive impairment and dementia. How living arrangements influence risk for cognitive disorder is less well understood in low-to-middle income countries (LMICs) where Alz…
View article: Enhancing Psychosis-Spectrum Nosology Through an International Data Sharing Initiative
Enhancing Psychosis-Spectrum Nosology Through an International Data Sharing Initiative Open
The latent structure of schizotypy and psychosis-spectrum symptoms remains poorly understood. Furthermore, molecular genetic substrates are poorly defined, largely due to the substantial resources required to collect rich phenotypic data a…
View article: Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling Open
The major anxiety disorders (ANX; including generalized anxiety disorder, panic disorder, and phobias ) are highly prevalent, often onset early, persist throughout life, and cause substantial global disability. Although distinct in their c…
View article: Meta-analysis of Genome wide Association Studies on Childhood ADHD Symptoms and Diagnosis Reveals 17 Novel Loci and 22 Potential Effector Genes
Meta-analysis of Genome wide Association Studies on Childhood ADHD Symptoms and Diagnosis Reveals 17 Novel Loci and 22 Potential Effector Genes Open
Attention-deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder for which genetic factors explain up to 75% of the variance. In this study, we performed a genome-wide association meta-analysis (GWAMA) of ADHD sym…
View article: Racialized Health Inequities: Quantifying Socioeconomic and Stress Pathways Using Moderated Mediation
Racialized Health Inequities: Quantifying Socioeconomic and Stress Pathways Using Moderated Mediation Open
Racism drives population health inequities by shaping the unequal distribution of key social determinants of health, such as socioeconomic resources and exposure to stressors. Research on interrelationships among race, socioeconomic resour…
View article: Investigating Moderation in the Prospective Relationship of Marijuana Use to Subsequent Illicit Substance Use: Evidence from Add Health
Investigating Moderation in the Prospective Relationship of Marijuana Use to Subsequent Illicit Substance Use: Evidence from Add Health Open
Whereas socially normalized substances (e.g., marijuana) may increase the probability of subsequent progression to more harmful illicit substances, previous empirical research on the topic has yielded inconsistent results. Few studies have…
View article: Neural text generation in regulatory medical writing
Neural text generation in regulatory medical writing Open
Background: A steep increase in new drug applications has increased the overhead of writing technical documents such as medication guides. Natural language processing can contribute to reducing this burden. Objective: To generate medicatio…
View article: Changes in Smoking Prevalence from Adolescence to Adulthood among Asian Americans: Evidence of Selective Acculturation across Gender
Changes in Smoking Prevalence from Adolescence to Adulthood among Asian Americans: Evidence of Selective Acculturation across Gender Open
It is well established that immigrant adolescents have lower smoking rates than their native-born counterparts. Although smoking rates among immigrants have been theorized to increase with U.S. acculturation, this hypothesis has seldom bee…
View article: Genetic association study of childhood aggression across raters, instruments, and age.
Genetic association study of childhood aggression across raters, instruments, and age. Open
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assesso…
View article: Genetic association study of childhood aggression across raters, instruments, and age
Genetic association study of childhood aggression across raters, instruments, and age Open
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assesso…
View article: Refinement of schizophrenia GWAS loci using methylome-wide association data
Refinement of schizophrenia GWAS loci using methylome-wide association data Open
Recent genome-wide association studies (GWAS) have made substantial progress in identifying disease loci. The next logical step is to design functional experiments to identify disease mechanisms. This step, however, is often hampered by th…
View article: Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice
Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice Open
Tardive dyskinesia (TD) is a debilitating, unpredictable and often irreversible side effect resulting from chronic treatment with typical antipsychotic agents such as haloperidol. TD is characterized by repetitive, involuntary, purposeless…
View article: Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood
Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood Open
The public health burden of alcohol is unevenly distributed across the life course, with levels of use, abuse, and dependence increasing across adolescence and peaking in early adulthood. Here, we leverage this temporal patterning to searc…
View article: Genes, Environments, and Developmental Research: Methods for a Multi-Site Study of Early Substance Abuse
Genes, Environments, and Developmental Research: Methods for a Multi-Site Study of Early Substance Abuse Open
The importance of including developmental and environmental measures in genetic studies of human pathology is widely acknowledged, but few empirical studies have been published. Barriers include the need for longitudinal studies that cover…
View article: Pathways to the all-volunteer military*
Pathways to the all-volunteer military* Open
The present study investigates the role of a disadvantaged background, the lack of social connectedness, and behavioral problems in channeling young men to the opportunities of the all-volunteer military instead of to college and the labor…
View article: A systematic method for estimating individual responses to treatment with antipsychotics in CATIE
A systematic method for estimating individual responses to treatment with antipsychotics in CATIE Open
In addition to comparing drug treatment groups, the wealth of genetic and clinical data collected in the Clinical Antipsychotic Trials of Intervention Effectiveness study offers tremendous opportunities to study individual differences in r…
View article: Early Environmental Correlates of Maternal Emotion Talk
Early Environmental Correlates of Maternal Emotion Talk Open
The primary goal of this study was to examine contextual, child, and maternal factors that are associated with mothers’ early emotion talk in an ethnically diverse, low-income sample.
View article: Genotype-Based Ancestral Background Consistently Predicts Efficacy and Side Effects across Treatments in CATIE and STAR*D
Genotype-Based Ancestral Background Consistently Predicts Efficacy and Side Effects across Treatments in CATIE and STAR*D Open
Only a subset of patients will typically respond to any given prescribed drug. The time it takes clinicians to declare a treatment ineffective leaves the patient in an impaired state and at unnecessary risk for adverse drug effects. Thus, …
View article: Genome-wide association study of patient and clinician rated global impression severity during antipsychotic treatment
Genome-wide association study of patient and clinician rated global impression severity during antipsychotic treatment Open
Examine the unique and congruent findings between multiple raters in a genome-wide association studies (GWAS) in the context of understanding individual differences in treatment response during antipsychotic therapy for schizophrenia.
View article: Genome-Wide Pharmacogenomic Study of Neurocognition As an Indicator of Antipsychotic Treatment Response in Schizophrenia
Genome-Wide Pharmacogenomic Study of Neurocognition As an Indicator of Antipsychotic Treatment Response in Schizophrenia Open
Neurocognitive deficits are a core feature of schizophrenia and, therefore, represent potentially critical outcome variables for assessing antipsychotic treatment response. We performed genome-wide association studies (GWAS) with 492K sing…
View article: MBD-seq as a cost-effective approach for methylome-wide association studies: demonstration in 1500 case–control samples
MBD-seq as a cost-effective approach for methylome-wide association studies: demonstration in 1500 case–control samples Open
We studied the use of methyl-CpG binding domain (MBD) protein-enriched genome sequencing (MBD-seq) as a cost-effective screening tool for methylome-wide association studies (MWAS).