Daniel E. Feldman
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View article: Distinct laminar origins of high-gamma and low-frequency ECoG signals revealed by optogenetics
Distinct laminar origins of high-gamma and low-frequency ECoG signals revealed by optogenetics Open
Electrocorticography (ECoG) provides a high-spatiotemporal-resolution measure of cortical activity (cortical surface electrical potentials, CSEPs) in humans and animals. The CSEP high-gamma band (Hγ, 65–170 Hz) correlates with neuronal fir…
View article: Reward history guides focal attention in whisker somatosensory cortex
Reward history guides focal attention in whisker somatosensory cortex Open
Prior reward is a potent cue for attentional capture, but the underlying neurobiology is largely unknown. In a whisker touch detection task, we show that mice flexibly shift attention between specific whiskers on a trial-by-trial timescale…
View article: Molecular states underlying neuronal cell type development and plasticity in the postnatal whisker cortex
Molecular states underlying neuronal cell type development and plasticity in the postnatal whisker cortex Open
Mouse whisker somatosensory cortex (wS1) is a major model system to study the experience-dependent plasticity of cortical neuron physiology, morphology, and sensory coding. However, the role of sensory experience in regulating neuronal cel…
View article: Physiological and molecular impairment of PV circuit homeostasis in mouse models of autism
Physiological and molecular impairment of PV circuit homeostasis in mouse models of autism Open
Summary Circuit dysfunction in autism may involve a failure of homeostatic plasticity. To test this, we studied parvalbumin (PV) interneurons which exhibit rapid homeostatic plasticity of intrinsic excitability following whisker deprivatio…
View article: Integrating salen complexes into gas diffusion electrodes for CO <sub>2</sub> electroreduction: considerations for employing molecular precatalysts in heterogeneous electrolyzers
Integrating salen complexes into gas diffusion electrodes for CO <sub>2</sub> electroreduction: considerations for employing molecular precatalysts in heterogeneous electrolyzers Open
Transition metal salen complexes (Co, Ni, Cu) are studied as precatalysts for CO 2 -to-CO electroreduction in zero-gap electrolyzers.
View article: Molecular states underlying neuronal cell type development and plasticity in the whisker cortex
Molecular states underlying neuronal cell type development and plasticity in the whisker cortex Open
Mouse whisker somatosensory cortex (wS1) is a major model system to study the experience-dependent plasticity of cortical neuron physiology, morphology, and sensory coding. However, the role of sensory experience in regulating neuronal cel…
View article: Degraded tactile coding in the Cntnap2 mouse model of autism
Degraded tactile coding in the Cntnap2 mouse model of autism Open
Atypical sensory processing is common in autism, but how neural coding is disrupted in sensory cortex is unclear. We evaluate whisker touch coding in L2/3 of somatosensory cortex (S1) in Cntnap2-/- mice, which have reduced inhibition. This…
View article: A Survey on Exploratory Spatiotemporal Visual Analytics Approaches for Climate Science
A Survey on Exploratory Spatiotemporal Visual Analytics Approaches for Climate Science Open
Climate science produces a wealth of complex, high-dimensional, multivariate data from observations and numerical models. These data are critical for understanding climate changes and their socioeconomic impacts. Climate scientists are con…
View article: Reward history guides focal attention in whisker somatosensory cortex
Reward history guides focal attention in whisker somatosensory cortex Open
Prior reward is a potent cue for attentional capture, but the underlying neurobiology is largely unknown. In a novel whisker touch detection task, we show that mice flexibly shift attention between specific whiskers on a trial-by-trial tim…
View article: Improving positively tuned voltage indicators for brightness and kinetics
Improving positively tuned voltage indicators for brightness and kinetics Open
The recent positively tuned ASAP4-family voltage indicators feature superior photostability compared to the negatively tuned ASAP3, but signal-to-noise ratios (SNRs) for spike detection were not significantly different. To improve spike de…
View article: Degraded tactile coding in the Cntnap2 mouse model of autism
Degraded tactile coding in the Cntnap2 mouse model of autism Open
Atypical sensory processing in autism involves altered neural circuit function and neural coding in sensory cortex, but the nature of coding disruption is poorly understood. We characterized neural coding in L2/3 of whisker somatosensory c…
View article: Circuit-level theories for sensory dysfunction in autism: convergence across mouse models
Circuit-level theories for sensory dysfunction in autism: convergence across mouse models Open
Individuals with autism spectrum disorder (ASD) exhibit a diverse range of behavioral features and genetic backgrounds, but whether different genetic forms of autism involve convergent pathophysiology of brain function is unknown. Here, we…
View article: Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex
Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex Open
Rodent sensory cortex contains salt-and-pepper maps of sensory features, whose structure is not fully known. Here we investigated the structure of the salt-and-pepper whisker somatotopic map among L2/3 pyramidal neurons in somatosensory co…
View article: VIP interneurons in mouse whisker S1 exhibit sensory and action-related signals during goal-directed behavior
VIP interneurons in mouse whisker S1 exhibit sensory and action-related signals during goal-directed behavior Open
SUMMARY Vasoactive intestinal peptide-expressing (VIP) interneurons, which constitute 10-15% of the cortical inhibitory neuron population 1,2 , have emerged as an important cell type for regulating excitatory cell activity based on behavio…
View article: Presynaptic NMDA Receptors: Newly Appreciated Roles in Cortical Synaptic Function and Plasticity
Presynaptic NMDA Receptors: Newly Appreciated Roles in Cortical Synaptic Function and Plasticity Open
Many aspects of synaptic development, plasticity, and neurotransmission are critically influenced by NMDA-type glutamate receptors (NMDARs). Moreover, dysfunction of NMDARs has been implicated in a broad array of neurological disorders, in…
View article: Data-Independent Structured Pruning of Neural Networks via Coresets
Data-Independent Structured Pruning of Neural Networks via Coresets Open
Model compression is crucial for deployment of neural networks on devices with limited computational and memory resources. Many different methods show comparable accuracy of the compressed model and similar compression rates. However, the …
View article: Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1
Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1 Open
Sensory maps in layer (L) 2/3 of rodent cortex lack precise functional column boundaries, and instead exhibit locally heterogeneous (salt-and-pepper) tuning superimposed on smooth global topography. Could this organization be a byproduct o…
View article: Whisker map organization in somatosensory cortex of awake, behaving mice
Whisker map organization in somatosensory cortex of awake, behaving mice Open
SUMMARY The whisker map in rodent somatosensory cortex is well characterized under anesthesia, but its organization during awake sensation, when cortical coding can differ strongly, is unknown. Using a novel behavioral task, we measured wh…
View article: Tactile enrichment drives emergence of functional columns and improves sensory coding in L2/3 of mouse S1
Tactile enrichment drives emergence of functional columns and improves sensory coding in L2/3 of mouse S1 Open
SUMMARY Sensory maps in layer (L) 2/3 of rodent cortex lack precise functional column boundaries, and instead exhibit locally heterogeneous tuning superimposed on smooth global topography. Could this organization be a byproduct of impoveri…
View article: A normalized template matching method for improving spike detection in extracellular voltage recordings
A normalized template matching method for improving spike detection in extracellular voltage recordings Open
Spike sorting is the process of detecting and clustering action potential waveforms from extracellular voltage recordings to identify spikes of putative single neurons. Typically, spike detection is done using a fixed voltage threshold and…