Daniel E. Geraghty
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View article: Profiling associations of interactive ligand–receptors (HLA class I and KIR gene products) with the progression to type 1 diabetes among seroconverted participants
Profiling associations of interactive ligand–receptors (HLA class I and KIR gene products) with the progression to type 1 diabetes among seroconverted participants Open
Aims/hypothesis The aim of this work was to explore associations between type 1 diabetes progression from stages 1 or 2 to stage 3 and interacting ligand–receptor complexes of HLA class I (HLA-I) and KIR gene products. Methods Applying nex…
View article: IgG and Fc Receptor Genetic Variation Associates With Functional Antibody Responses in a DNA and Protein Candidate HIV Vaccine Trial
IgG and Fc Receptor Genetic Variation Associates With Functional Antibody Responses in a DNA and Protein Candidate HIV Vaccine Trial Open
Background: The HVTN108 trial evaluated the safety and immunogenicity of a DNA prime, adjuvanted protein boost HIV vaccine in the United States and South Africa. The underlying factors influencing individual variation in vaccine responsive…
View article: Two DRB3 residues predictively associate with the progression to type 1 diabetes among DR3 carriers
Two DRB3 residues predictively associate with the progression to type 1 diabetes among DR3 carriers Open
HLA-DR genes are associated with the progression from stage 1 and stage 2 to onset of stage 3 type 1 diabetes (T1D), after accounting HLA-DQ genes with which they are in high linkage disequilibrium. Based on an integrated cohort of partici…
View article: Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5
Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5 Open
Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) is the most advanced blood-stage malaria vaccine candidate and is being evaluated for efficacy in endemic regions, emphasizing the need to study the underlying antibody res…
View article: Oral Insulin Delay of Stage 3 Type 1 Diabetes Revisited in <i>HLA DR4-DQ8</i> Participants in the TrialNet Oral Insulin Prevention Trial (TN07)
Oral Insulin Delay of Stage 3 Type 1 Diabetes Revisited in <i>HLA DR4-DQ8</i> Participants in the TrialNet Oral Insulin Prevention Trial (TN07) Open
OBJECTIVE To explore if oral insulin could delay onset of stage 3 type 1 diabetes (T1D) among patients with stage 1/2 who carry HLA DR4-DQ8 and/or have elevated levels of IA-2 autoantibodies (IA-2As). RESEARCH AND METHODS Next-generation t…
View article: Oral insulin delay of Stage 3 type 1 diabetes revisited in HLA DR4-DQ8 participants in the TrialNet Oral Insulin Prevention Trial (TN-07)
Oral insulin delay of Stage 3 type 1 diabetes revisited in HLA DR4-DQ8 participants in the TrialNet Oral Insulin Prevention Trial (TN-07) Open
Objective To explore if oral insulin could delay onset of stage 3 type 1 diabetes (T1D) among stage 1/2 patients who carry HLA DR4-DQ8 and/or have elevated levels of IA-2 autoantibodies (IA-2A).Research and methods Next generation targeted…
View article: Oral insulin delay of Stage 3 type 1 diabetes revisited in HLA DR4-DQ8 participants in the TrialNet Oral Insulin Prevention Trial (TN-07)
Oral insulin delay of Stage 3 type 1 diabetes revisited in HLA DR4-DQ8 participants in the TrialNet Oral Insulin Prevention Trial (TN-07) Open
Objective To explore if oral insulin could delay onset of stage 3 type 1 diabetes (T1D) among stage 1/2 patients who carry HLA DR4-DQ8 and/or have elevated levels of IA-2 autoantibodies (IA-2A).Research and methods Next generation targeted…
View article: HLA Class II (<i>DR</i>, <i>DQ, DP</i>) Genes Were Separately Associated With the Progression From Seroconversion to Onset of Type 1 Diabetes Among Participants in Two Diabetes Prevention Trials (DPT-1 and TN07)
HLA Class II (<i>DR</i>, <i>DQ, DP</i>) Genes Were Separately Associated With the Progression From Seroconversion to Onset of Type 1 Diabetes Among Participants in Two Diabetes Prevention Trials (DPT-1 and TN07) Open
OBJECTIVE To explore associations of HLA class II genes (HLAII) with the progression of islet autoimmunity from asymptomatic to symptomatic type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS Next-generation targeted sequencing was used to …
View article: HLA Class II (<i>DR</i>, <i>DQ,</i> <i>DP</i>) genes were separately associated with the progression from seroconversion to onset of type 1 diabetes among participants in two diabetes prevention trials (DPT-1 and TN07)
HLA Class II (<i>DR</i>, <i>DQ,</i> <i>DP</i>) genes were separately associated with the progression from seroconversion to onset of type 1 diabetes among participants in two diabetes prevention trials (DPT-1 and TN07) Open
Objective To explore associations of HLA class II genes (HLAII) with the progression of islet autoimmunity from asymptomatic to symptomatic type 1 diabetes (T1D).Research design and methods Next-generation targeted sequencing was used to g…
View article: HLA Class II (<i>DR</i>, <i>DQ,</i> <i>DP</i>) genes were separately associated with the progression from seroconversion to onset of type 1 diabetes among participants in two diabetes prevention trials (DPT-1 and TN07)
HLA Class II (<i>DR</i>, <i>DQ,</i> <i>DP</i>) genes were separately associated with the progression from seroconversion to onset of type 1 diabetes among participants in two diabetes prevention trials (DPT-1 and TN07) Open
Objective To explore associations of HLA class II genes (HLAII) with the progression of islet autoimmunity from asymptomatic to symptomatic type 1 diabetes (T1D).Research design and methods Next-generation targeted sequencing was used to g…
View article: Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5
Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5 Open
Plasmodium falciparum RH5 is the most advanced blood-stage malaria vaccine candidate and is under evaluation for efficacy in endemic regions, emphasizing the need to study the underlying antibody response to RH5 during natural infection. H…
View article: A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses
A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses Open
The engineered outer domain germline targeting version 8 (eOD-GT8) 60-mer nanoparticle was designed to prime VRC01-class HIV-specific B cells that would need to be matured, through additional heterologous immunizations, into B cells that a…
View article: <i>KIR</i> genotype and haplotype repertoire in Kuwaiti healthy donors, hematopoietic cell transplant recipients and healthy family members
<i>KIR</i> genotype and haplotype repertoire in Kuwaiti healthy donors, hematopoietic cell transplant recipients and healthy family members Open
The gene complex located on chromosome 19q13.4 encodes the Killer‐cell Immunoglobulin‐like Receptors ( KIR s), which exhibit remarkable polymorphism in both gene content and sequences. Further, the repertoire of KIR genes varies within and…
View article: Using Haplotype-Based Artificial Intelligence to Evaluate SARS-CoV-2 Novel Variants and Mutations
Using Haplotype-Based Artificial Intelligence to Evaluate SARS-CoV-2 Novel Variants and Mutations Open
Importance Earlier detection of emerging novel SARS-COV-2 variants is important for public health surveillance of potential viral threats and for earlier prevention research. Artificial intelligence may facilitate early detection of SARS-C…
View article: Trivalent mosaic or consensus HIV immunogens prime humoral and broader cellular immune responses in adults
Trivalent mosaic or consensus HIV immunogens prime humoral and broader cellular immune responses in adults Open
BACKGROUNDMosaic and consensus HIV-1 immunogens provide two distinct approaches to elicit greater breadth of coverage against globally circulating HIV-1 and have shown improved immunologic breadth in nonhuman primate models.METHODSThis dou…
View article: Alternative splicing and genetic variation of mhc-e: implications for rhesus cytomegalovirus-based vaccines
Alternative splicing and genetic variation of mhc-e: implications for rhesus cytomegalovirus-based vaccines Open
Rhesus cytomegalovirus (RhCMV)-based vaccination against Simian Immunodeficiency virus (SIV) elicits MHC-E-restricted CD8+ T cells that stringently control SIV infection in ~55% of vaccinated rhesus macaques (RM). However, it is unclear ho…
View article: Alternative splicing and genetic variation of MHC-E: Implications for rhesus cytomegalovirus-based vaccines
Alternative splicing and genetic variation of MHC-E: Implications for rhesus cytomegalovirus-based vaccines Open
We used long-read sequencing to interrogate rhesus macaque (RM) MHC-E (Mamu-E) alternative splicing and genetic variations. Full-length Mamu-E RNA isoforms were recovered using the PacBio Iso-Seq method. Incomplete 5' ends of Mamu-E isofor…
View article: Alternative splicing and genetic variation of MHC-E: Implications for rhesus cytomegalovirus-based vaccines
Alternative splicing and genetic variation of MHC-E: Implications for rhesus cytomegalovirus-based vaccines Open
We used long-read sequencing to interrogate rhesus macaque (RM) MHC-E (Mamu-E) alternative splicing and genetic variations. Full-length Mamu-E RNA isoforms were recovered using the PacBio Iso-Seq method. Incomplete 5' ends of Mamu-E isofor…
View article: Application of Statistical Learning to Identify Omicron Mutations in SARS-CoV-2 Viral Genome Sequence Data From Populations in Africa and the United States
Application of Statistical Learning to Identify Omicron Mutations in SARS-CoV-2 Viral Genome Sequence Data From Populations in Africa and the United States Open
Importance With timely collection of SARS-CoV-2 viral genome sequences, it is important to apply efficient data analytics to detect emerging variants at the earliest time. Objective To evaluate the application of a statistical learning str…
View article: High‐resolution HLA class II sequencing of Swedish multiple sclerosis patients
High‐resolution HLA class II sequencing of Swedish multiple sclerosis patients Open
Multiple sclerosis (MS) is a chronic neurological disease believed to be caused by autoimmune pathogenesis. The aetiology is likely explained by a complex interplay between inherited and environmental factors. Genetic investigations into M…
View article: Genotyping of canine <scp>MHC</scp> gene <scp>DLA</scp>‐88 by next‐generation sequencing reveals high frequencies of new allele discovery and gene duplication
Genotyping of canine <span>MHC</span> gene <span>DLA</span>‐88 by next‐generation sequencing reveals high frequencies of new allele discovery and gene duplication Open
Dogs have served as one of the most reliable preclinical models for a variety of diseases and treatments, including stem/progenitor cell transplantation. At the genetic epicenter of dog transplantation models, polymorphic major histocompat…
View article: Broadly neutralizing antibodies target the coronavirus fusion peptide
Broadly neutralizing antibodies target the coronavirus fusion peptide Open
The potential for future coronavirus outbreaks highlights the need to broadly target this group of pathogens. We used an epitope-agnostic approach to identify six monoclonal antibodies that bind to spike proteins from all seven human-infec…
View article: Alternative splicing and genetic variation of MHC-E: Implications for rhesus cytomegalovirus-based vaccines
Alternative splicing and genetic variation of MHC-E: Implications for rhesus cytomegalovirus-based vaccines Open
Rhesus cytomegalovirus (RhCMV)-based vaccination against Simian Immunodeficiency virus (SIV) elicits MHC-E-restricted CD8 + T cells that stringently control SIV infection in ~ 55% of vaccinated rhesus macaques (RM). However, it is unclear …
View article: Two residues (-18β and β57) in the HLA-DQ heterodimer were critically associated with progression from islet autoimmunity to diabetes in the DPT-1 trial.
Two residues (-18β and β57) in the HLA-DQ heterodimer were critically associated with progression from islet autoimmunity to diabetes in the DPT-1 trial. Open
Objective The purpose was to test the hypothesis that HLA DQab heterodimer structure was related to the progression of islet autoimmunity from asymptomatic to symptomatic type 1 diabetes (T1D). Research design and methods Next generation t…