Daniel E. K. Kabotso
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View article: In Vitro Evaluation of Rosemary Essential Oil: GC-MS Profiling, Antibacterial Synergy, and Biofilm Inhibition
In Vitro Evaluation of Rosemary Essential Oil: GC-MS Profiling, Antibacterial Synergy, and Biofilm Inhibition Open
Background: Antimicrobial resistance (AMR) has become precarious, warranting investments in antimicrobial discovery. Aim: To investigate the antibacterial activity of rosemary essential oil (REO), alone and in combination with selected con…
View article: Study of the Effects of Remote Heavy Group Vibrations on the Temperature Dependence of Hydride Kinetic Isotope Effects of the NADH/NAD<sup>+</sup> Model Reactions
Study of the Effects of Remote Heavy Group Vibrations on the Temperature Dependence of Hydride Kinetic Isotope Effects of the NADH/NAD<sup>+</sup> Model Reactions Open
It has recently been observed that the temperature(T)-dependence of KIEs in H-tunneling reactions, characterized by isotopic activation energy difference (ΔEa = EaD - EaH), is correlated to the rigidity of the tunneling ready states (TRSs)…
View article: Investigating the Levels of Polychlorinated Biphenyls (PCBs) at Three Lactational stages: A comprehensive Study in Ghana
Investigating the Levels of Polychlorinated Biphenyls (PCBs) at Three Lactational stages: A comprehensive Study in Ghana Open
Background: The human breast secretes three types of milk during lactation – colostrum, transitional milk and mature milk. However, like any other biofluid, human breast milk is not pristine.
View article: Multidrug-Resistant Bacteria in Aquaculture Systems in Accra, Ghana
Multidrug-Resistant Bacteria in Aquaculture Systems in Accra, Ghana Open
Background: Antibiotic resistance (ABR) poses a critical global health challenge, necessitating its surveillance across both human and animal health sectors. This study evaluated ABR in bacteria harboured in reared inland fishes sold in Ac…
View article: Investigating the levels of polychlorinated biphenyls (PCBs) at three lactational stages: A comprehensive study in Ghana
Investigating the levels of polychlorinated biphenyls (PCBs) at three lactational stages: A comprehensive study in Ghana Open
Introduction The human breast secretes three types of milk during lactation – colostrum, transitional milk and mature milk However, like any other biofluid, human breast milk is not pristine Objectives The objectives of this study was to d…
View article: <i>In vitro</i> antimicrobial activity of crude propolis extracts and fractions
<i>In vitro</i> antimicrobial activity of crude propolis extracts and fractions Open
The search for antimicrobials in propolis presents a new dimension for addressing the problem of antimicrobial drug resistance. The aim of this study was to determine the antimicrobial activity of extracts of crude propolis collected from …
View article: Design and synthesis of multivalent α-1,2-trimannose-linked bioerodible microparticles for applications in immune response studies of <i>Leishmania major</i> infection
Design and synthesis of multivalent α-1,2-trimannose-linked bioerodible microparticles for applications in immune response studies of <i>Leishmania major</i> infection Open
Leishmaniasis, a neglected tropical disease, currently infects approximately 12 million people worldwide with 1 to 2 million new cases each year in predominately underdeveloped countries. The treatment of the disease is severely underdevel…
View article: Leishmania-Derived Trimannose Modulates the Inflammatory Response To Significantly Reduce Leishmania major-Induced Lesions
Leishmania-Derived Trimannose Modulates the Inflammatory Response To Significantly Reduce Leishmania major-Induced Lesions Open
Leishmania lipophosphoglycan (LPG) is a key virulence factor, initiating inflammation resulting in cutaneous lesions. LPG is capped by various oligosaccharides. How these glycans are recognized and how they alter the course of Leishmania i…
View article: Protocol for the purification of protected carbohydrates: toward coupling automated synthesis to alternate-pump recycling high-performance liquid chromatography
Protocol for the purification of protected carbohydrates: toward coupling automated synthesis to alternate-pump recycling high-performance liquid chromatography Open
Analytical techniques that can be coupled to automated oligosaccharide synthesis platforms are needed to purify to homogeneity protected carbohydrates at levels of ≥99.5% purity.