Daniel E. Larcombe
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View article: Sequence and origin of the Streptomyces intergenetic-conjugation helper plasmid pUZ8002
Sequence and origin of the Streptomyces intergenetic-conjugation helper plasmid pUZ8002 Open
Conjugation of plasmids from Escherichia coli is essential for the genetic manipulation of Streptomyces spp. To facilitate intergeneric conjugation from E. coli to Streptomyces the conjugative machinery required for genetic transfer is usu…
View article: Impact of secreted glucanases upon the cell surface and fitness of Candida albicans during colonisation and infection
Impact of secreted glucanases upon the cell surface and fitness of Candida albicans during colonisation and infection Open
Host recognition of the pathogen-associated molecular pattern (PAMP), β-1,3-glucan, plays a major role in antifungal immunity. β-1,3-glucan is an essential component of the inner cell wall of the opportunistic pathogen Candida albicans. Mo…
View article: Sequence and origin of the Streptomyces intergenetic-conjugation helper plasmid pUZ8002.
Sequence and origin of the Streptomyces intergenetic-conjugation helper plasmid pUZ8002. Open
Conjugation of plasmids from Escherichia coli is essential for the genetic manipulation of Streptomyces spp. To facilitate intergeneric conjugation from E. coli to Streptomyces the conjugative machinery required for genetic transfer is usu…
View article: Reviewer response for version 1
Reviewer response for version 1 Open
Conjugation of plasmids from Escherichia coli is essential for the genetic manipulation of Streptomyces spp. To facilitate intergeneric conjugation from E. coli to Streptomyces the conjugative machinery required for genetic transfer is usu…
View article: Sequence and origin of the Streptomyces intergenetic-conjugation helper plasmid pUZ8002.
Sequence and origin of the Streptomyces intergenetic-conjugation helper plasmid pUZ8002. Open
Conjugation of plasmids from Escherichia coli is essential for the genetic manipulation of Streptomyces spp. To facilitate intergeneric conjugation from E. coli to Streptomyces the conjugative machinery required for genetic transfer is usu…
View article: A CO <sub>2</sub> sensing module modulates β-1,3-glucan exposure in <i>Candida albicans</i>
A CO <sub>2</sub> sensing module modulates β-1,3-glucan exposure in <i>Candida albicans</i> Open
Our innate immune defenses have evolved to protect us against microbial infection in part via receptor-mediated detection of “pathogen-associated molecular patterns” (PAMPs) expressed by invading microbes, which then triggers their immune …
View article: Glucose-enhanced oxidative stress resistance—A protective anticipatory response that enhances the fitness of Candida albicans during systemic infection
Glucose-enhanced oxidative stress resistance—A protective anticipatory response that enhances the fitness of Candida albicans during systemic infection Open
Most microbes have developed responses that protect them against stresses relevant to their niches. Some that inhabit reasonably predictable environments have evolved anticipatory responses that protect against impending stresses that are …
View article: Nature of β-1,3-Glucan-Exposing Features on Candida albicans Cell Wall and Their Modulation
Nature of β-1,3-Glucan-Exposing Features on Candida albicans Cell Wall and Their Modulation Open
Microbes that coexist with humans have evolved ways of avoiding or evading our immunological defenses. These include the masking by these microbes of their “pathogen-associated molecular patterns” (PAMPs), which are recognized as “foreign”…
View article: S9.4c Diverse environmental inputs mediate changes in β-glucan exposure at the <i>Candida albicans</i> cell surface thereby influencing tissue colonisation during systemic infection
S9.4c Diverse environmental inputs mediate changes in β-glucan exposure at the <i>Candida albicans</i> cell surface thereby influencing tissue colonisation during systemic infection Open
S9.4 Free oral presentations (late breaking), September 23, 2022, 4:45 PM - 6:15 PM Candida albicans adaptation to host niches affects the exposure of key pathogen-associated molecular patterns (PAMPs) on its cell surface and, consequently…
View article: Immune cells fold and damage fungal hyphae
Immune cells fold and damage fungal hyphae Open
Significance Macrophages protect against microbial infection, in part by engulfing and killing invading microbes. Fungal pathogens such as Candida albicans are known to evade phagocytic killing by forming hyphae that are physically challen…
View article: Anticipatory Stress Responses and Immune Evasion in Fungal Pathogens
Anticipatory Stress Responses and Immune Evasion in Fungal Pathogens Open
In certain niches, microbes encounter environmental challenges that are temporally linked. In such cases, microbial fitness is enhanced by the evolution of anticipatory responses where the initial challenge simultaneously activates pre-emp…
View article: Fungal Transformers: Tracking a Moving Target
Fungal Transformers: Tracking a Moving Target Open
In human hosts, the opportunistic fungal pathogen Candida albicans primarily proliferates in nutrient diverse niches. Environmental condition sensing regulates several fungal cellular features including, but not limited to, metabolism, cel…
View article: Hypoxia Promotes Immune Evasion by Triggering β-Glucan Masking on the Candida albicans Cell Surface via Mitochondrial and cAMP-Protein Kinase A Signaling
Hypoxia Promotes Immune Evasion by Triggering β-Glucan Masking on the Candida albicans Cell Surface via Mitochondrial and cAMP-Protein Kinase A Signaling Open
Animal, plant, and fungal cells occupy environments that impose changes in oxygen tension. Consequently, many species have evolved mechanisms that permit robust adaptation to these changes. The fungal pathogen Candida albicans can colonize…
View article: Rapid Identification of Clinically Relevant Members of the Genus Exophiala by Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry and Description of Two Novel Species, Exophiala campbellii and Exophiala lavatrina
Rapid Identification of Clinically Relevant Members of the Genus Exophiala by Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry and Description of Two Novel Species, Exophiala campbellii and Exophiala lavatrina Open
Exophiala is a ubiquitous pleomorphic genus comprising at least 40 species, many of which have been associated with superficial, visceral, or systemic infections in humans, other mammals, or cold-blooded animals. In this study, we investig…