Daniel E. Singer
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View article: Enhancing Patient Understanding of Perianal Fistula MRI Findings Using ChatGPT: A Randomized, Single Centre Study
Enhancing Patient Understanding of Perianal Fistula MRI Findings Using ChatGPT: A Randomized, Single Centre Study Open
Background/Objectives: Large Language Models (LLMs) may help translate complex Magnetic Resonance Imaging (MRI) fistula reports into accessible, patient-friendly summaries. This study evaluated the clinical utility, safety, and patient acc…
View article: Artificial intelligence-enabled analysis of handheld single-lead electrocardiograms to predict incident atrial fibrillation: an analysis of the VITAL-AF randomized trial
Artificial intelligence-enabled analysis of handheld single-lead electrocardiograms to predict incident atrial fibrillation: an analysis of the VITAL-AF randomized trial Open
Whether artificial intelligence (AI) analysis of single-lead ECG (1 L ECG) can predict incident AF is unknown. In the VITAL-AF trial (ClinicalTrials.gov NCT03515057, registered 2/24/2021) of primary care patients aged ≥65 years undergoing …
View article: AI-Generated Patient-Friendly MRI Fistula Summaries: A Pilot Randomised Study
AI-Generated Patient-Friendly MRI Fistula Summaries: A Pilot Randomised Study Open
Perianal fistulising Crohn’s disease (pfCD) affects 1 in 5 Crohn’s patients and requires frequent MRI monitoring. Standard radiology reports are written for clinicians using technical language often inaccessible to patients, which can caus…
View article: Clinical Outcomes of Switching From Warfarin to Apixaban or Rivaroxaban in Patients With Atrial Fibrillation: A Nationwide Multidatabase Study
Clinical Outcomes of Switching From Warfarin to Apixaban or Rivaroxaban in Patients With Atrial Fibrillation: A Nationwide Multidatabase Study Open
BACKGROUND: The benefits of switching from warfarin to direct oral anticoagulants in atrial fibrillation remain unclear. METHODS: This retrospective study used the Medicare fee-for-service (2013–2020) and Optum Deidentified Clinformatics D…
View article: Association of Rate‐Control and Antiarrhythmic Medication Use and Risk of Ischemic Stroke and Death in Patients on Dialysis With Atrial Fibrillation
Association of Rate‐Control and Antiarrhythmic Medication Use and Risk of Ischemic Stroke and Death in Patients on Dialysis With Atrial Fibrillation Open
Background Incident atrial fibrillation (AF) is common among adults with kidney failure treated with maintenance dialysis and is associated with poor clinical outcomes. Limited data exist informing treatment of AF among patients on dialysi…
View article: Internet of the Environment (IoE) and Eddy Covariance-based Ecosystem Fluxes
Internet of the Environment (IoE) and Eddy Covariance-based Ecosystem Fluxes Open
The Internet of the Environment (IoE) represents a subset of the Internet of Things (IoT) where connected environmental monitoring sensors, that utilize edge computing and embedded power and communications, report on the state of the envir…
View article: Comparative Effectiveness and Safety of Apixaban, Rivaroxaban, and Warfarin in Patients With Cirrhosis and Atrial Fibrillation
Comparative Effectiveness and Safety of Apixaban, Rivaroxaban, and Warfarin in Patients With Cirrhosis and Atrial Fibrillation Open
National Institutes of Health.
View article: Assessment of Days Alive Out of Hospital as a Possible End Point in Trials of Stroke Prevention for Atrial Fibrillation: A ROCKET AF Analysis
Assessment of Days Alive Out of Hospital as a Possible End Point in Trials of Stroke Prevention for Atrial Fibrillation: A ROCKET AF Analysis Open
Background Days alive out of hospital (DAOH) is an objective and patient‐centered net benefit end point. There are no assessments of DAOH in clinical trials of interventions for atrial fibrillation (AF), and it is not known whether this en…
View article: Identifying a Heterogeneous Effect of Atrial Fibrillation Screening in Older Adults: A Secondary Analysis of the VITAL-AF Trial
Identifying a Heterogeneous Effect of Atrial Fibrillation Screening in Older Adults: A Secondary Analysis of the VITAL-AF Trial Open
Background One-time atrial fibrillation (AF) screening trials have produced mixed results; we sought a subset for whom screening is effective. Methods We conducted a secondary analysis of VITAL-AF, a randomized trial of one-time, brief, si…
View article: Development and Validation of an Intracranial Hemorrhage Risk Score in Older Adults with Atrial Fibrillation Treated with Oral Anticoagulant
Development and Validation of an Intracranial Hemorrhage Risk Score in Older Adults with Atrial Fibrillation Treated with Oral Anticoagulant Open
Our novel claims-based ICH risk prediction model outperformed the standard HAS-BLED score and can inform OAC prescribing decisions.
View article: Predicting post-stroke cognitive impairment using electronic health record data
Predicting post-stroke cognitive impairment using electronic health record data Open
Background: Secondary prevention interventions to reduce post-stroke cognitive impairment (PSCI) can be aided by the early identification of high-risk individuals who would benefit from risk factor modification. Aims: To develop and evalua…
View article: Patient Characteristics Associated With Using Transcatheter Left Atrial Appendage Occlusion Versus Oral Anticoagulants for Atrial Fibrillation
Patient Characteristics Associated With Using Transcatheter Left Atrial Appendage Occlusion Versus Oral Anticoagulants for Atrial Fibrillation Open
BACKGROUND: Transcatheter left atrial appendage occlusion (LAAO) is an alternative to oral anticoagulants (OACs) for stroke prevention in patients with atrial fibrillation, but the predictors of LAAO use in routine care are unclear. We aim…
View article: Predicting post-stroke cognitive impairment using electronic health record data
Predicting post-stroke cognitive impairment using electronic health record data Open
Importance Secondary prevention interventions to reduce post-stroke cognitive impairment (PSCI) can be aided by the early identification of high-risk individuals who would benefit from risk factor modification. Objective To develop and eva…
View article: Characteristics and Attitudes of Wearable Device Users and Nonusers in a Large Health Care System
Characteristics and Attitudes of Wearable Device Users and Nonusers in a Large Health Care System Open
Background Consumer wearable devices with health and wellness features are increasingly common and may enhance disease detection and management. Yet studies informing relationships between wearable device use, attitudes toward device data,…
View article: A Lifestyle Modification Program for Secondary Prevention of Atrial Fibrillation: Introductory Findings
A Lifestyle Modification Program for Secondary Prevention of Atrial Fibrillation: Introductory Findings Open
Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with a fivefold increased risk of stroke, and with significant morbidity and risk of hospitalization.1,2 Lifestyle modification may represent an opportunity to imp…
View article: Frailty, Home Time, and Health Care Costs in Older Adults With Atrial Fibrillation Receiving Oral Anticoagulants
Frailty, Home Time, and Health Care Costs in Older Adults With Atrial Fibrillation Receiving Oral Anticoagulants Open
Importance There are no data on patient-centered outcomes and health care costs by frailty in patients with atrial fibrillation (AF) taking oral anticoagulants (OACs). Objective To compare home time, clinical events, and health care costs …
View article: Development and validation of the DOAC Score: a novel bleeding risk prediction tool for patients with atrial fibrillation
Development and validation of the DOAC Score: a novel bleeding risk prediction tool for patients with atrial fibrillation Open
Background Clinicians and patients must balance the ischemic benefits and bleeding risks when deciding to anticoagulate patients with atrial fibrillation (AF). Current clinical decision tools for assessing bleeding risk have limited perfor…
View article: A Lifestyle Modification Program for Secondary Prevention of Atrial Fibrillation: A Pilot Study
A Lifestyle Modification Program for Secondary Prevention of Atrial Fibrillation: A Pilot Study Open
Background Lifestyle modification programs, such as cardiac rehabilitation, may reduce atrial fibrillation (AF) burden and improve quality of life (QOL), but remain unproven. The objective of this pilot study was to assess feasibility, acc…
View article: Performance of Single-Lead Handheld Electrocardiograms for Atrial Fibrillation Screening in Primary Care
Performance of Single-Lead Handheld Electrocardiograms for Atrial Fibrillation Screening in Primary Care Open
In an older primary care population undergoing AF screening with handheld 1L ECGs, automated algorithm interpretations were sufficiently accurate to exclude the presence of AF but not to establish an AF diagnosis.
View article: Development and Validation of the DOAC Score: A Novel Bleeding Risk Prediction Tool for Patients With Atrial Fibrillation on Direct-Acting Oral Anticoagulants
Development and Validation of the DOAC Score: A Novel Bleeding Risk Prediction Tool for Patients With Atrial Fibrillation on Direct-Acting Oral Anticoagulants Open
BACKGROUND: Current clinical decision tools for assessing bleeding risk in individuals with atrial fibrillation (AF) have limited performance and were developed for individuals treated with warfarin. This study develops and validates a cli…
View article: Predictors of intracranial hemorrhage in patients with atrial fibrillation treated with oral anticoagulants: Insights from the GARFIELD‐AF and ORBIT‐AF registries
Predictors of intracranial hemorrhage in patients with atrial fibrillation treated with oral anticoagulants: Insights from the GARFIELD‐AF and ORBIT‐AF registries Open
Background An unmet need exists to reliably predict the risk of intracranial hemorrhage (ICH) in patients with atrial fibrillation (AF) treated with oral anticoagulants (OACs). Hypothesis An externally validated model improves ICH risk str…
View article: Characteristics and Attitudes of Wearable Device Users and Non-Users in a Large Healthcare System
Characteristics and Attitudes of Wearable Device Users and Non-Users in a Large Healthcare System Open
Introduction Consumer wearable devices with health and wellness features are increasingly common and may enhance prevention and management of cardiovascular disease. However, the characteristics and attitudes of wearable device users versu…
View article: Effect of clinic-based single-lead electrocardiogram rhythm assessment on oral anticoagulation prescriptions in patients with previously diagnosed atrial fibrillation
Effect of clinic-based single-lead electrocardiogram rhythm assessment on oral anticoagulation prescriptions in patients with previously diagnosed atrial fibrillation Open
Including patients with previously diagnosed AF in a point-of-care rhythm assessment strategy did not increase overall OAC use compared to the control arm. However, the rhythm assessment result influenced both initiation and discontinuatio…
View article: Screening for undiagnosed atrial fibrillation using a single-lead electrocardiogram at primary care visits: patient uptake and practitioner perspectives from the VITAL-AF trial
Screening for undiagnosed atrial fibrillation using a single-lead electrocardiogram at primary care visits: patient uptake and practitioner perspectives from the VITAL-AF trial Open
Background Screening for atrial fibrillation (AF) is appealing because AF is common, when undiagnosed may increase stroke risk, and stroke is preventable with anticoagulants. This study assessed patient and primary care practitioner (PCP) …
View article: Can Treatment Support Mitigate Nicotine Metabolism-Based Disparities in Smoking Abstinence? Secondary Analysis of the Helping HAND 4 Trial
Can Treatment Support Mitigate Nicotine Metabolism-Based Disparities in Smoking Abstinence? Secondary Analysis of the Helping HAND 4 Trial Open
Introduction The nicotine metabolite ratio (NMR), a biomarker of CYP2A6-mediated nicotine metabolism, predicts the efficacy of nicotine replacement therapy (NRT), with fast metabolizers benefiting less than slow metabolizers. Whether treat…
View article: Identification of recurrent atrial fibrillation using natural language processing applied to electronic health records
Identification of recurrent atrial fibrillation using natural language processing applied to electronic health records Open
Aims This study aimed to develop and apply natural language processing (NLP) algorithms to identify recurrent atrial fibrillation (AF) episodes following rhythm control therapy initiation using electronic health records (EHRs). Methods and…
View article: Comparative Effectiveness and Safety of Oral Anticoagulants by Dementia Status in Older Patients With Atrial Fibrillation
Comparative Effectiveness and Safety of Oral Anticoagulants by Dementia Status in Older Patients With Atrial Fibrillation Open
Importance The development of an optimal stroke prevention strategy, including the use of oral anticoagulant (OAC) therapy, is particularly important for patients with atrial fibrillation (AF) who are living with dementia, a condition that…
View article: Incident Atrial Fibrillation and Risk of Dementia in a Diverse, Community‐Based Population
Incident Atrial Fibrillation and Risk of Dementia in a Diverse, Community‐Based Population Open
Background Atrial fibrillation (AF) is the most common, clinically relevant arrhythmia in adults and associated with ischemic stroke and premature death. However, data are conflicting on whether AF is independently associated with risk of …