Daniel E. Strongin
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View article: Serum factors create species-specific barriers to hepatic gene transfer by lipid nanoparticles in liver-humanized mice
Serum factors create species-specific barriers to hepatic gene transfer by lipid nanoparticles in liver-humanized mice Open
View article: Viral gene drive spread during herpes simplex virus 1 infection in mice
Viral gene drive spread during herpes simplex virus 1 infection in mice Open
Gene drives are genetic modifications designed to propagate efficiently through a population. Most applications rely on homologous recombination during sexual reproduction in diploid organisms such as insects, but we recently developed a g…
View article: Gene editing for latent herpes simplex virus infection reduces viral load and shedding in vivo
Gene editing for latent herpes simplex virus infection reduces viral load and shedding in vivo Open
Anti-HSV therapies are only suppressive because they do not eliminate latent HSV present in ganglionic neurons, the source of recurrent disease. We have developed a potentially curative approach against HSV infection, based on gene editing…
View article: Viral gene drive spread during herpes simplex virus 1 infection in mice
Viral gene drive spread during herpes simplex virus 1 infection in mice Open
Gene drives are genetic modifications designed to propagate efficiently through a population. Most applications rely on homologous recombination during sexual reproduction in diploid organisms such as insects, but we recently developed a g…
View article: A multiplexed barcode approach to simultaneously evaluate gene delivery by adeno-associated virus capsid variants in nonhuman primates
A multiplexed barcode approach to simultaneously evaluate gene delivery by adeno-associated virus capsid variants in nonhuman primates Open
Background and Aims: Adeno-associated virus (AAV) vectors are widely used to deliver therapeutic transgenes to distinct tissues, including the liver. Vectors based on naturally occurring AAV serotypes as well as vectors using engineered ca…
View article: AAV-delivered gene editing for latent genital or orofacial herpes simplex virus infection reduces ganglionic viral load and minimizes subsequent viral shedding in mice
AAV-delivered gene editing for latent genital or orofacial herpes simplex virus infection reduces ganglionic viral load and minimizes subsequent viral shedding in mice Open
Herpes simplex virus (HSV) establishes latency in ganglionic neurons of the peripheral nervous system, from which it can reactivate, causing recurrent disease and possible transmission to a new host. Current anti-HSV therapy does not elimi…
View article: Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes
Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes Open
Plant homeodomain (PHD) finger-containing proteins are implicated in fundamental biological processes, including transcriptional activation and repression, DNA damage repair, cell differentiation, and survival. The PHD finger functions as …
View article: Gene editing and elimination of latent herpes simplex virus in vivo
Gene editing and elimination of latent herpes simplex virus in vivo Open
View article: Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes
Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes Open
Plant homeodomain (PHD) finger-containing proteins are implicated in fundamental biological processes, including transcriptional activation and repression, DNA damage repair, cell differentiation, and survival. The PHD finger functions as …