Daniel E. Syroid
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View article: Induction of postnatal schwann cell death by the low-affinity neurotrophin receptor in vitro and after axotomy.
Induction of postnatal schwann cell death by the low-affinity neurotrophin receptor in vitro and after axotomy. Open
Schwann cells express the low-affinity neurotrophin receptor (p75), but no role for either the neurotrophins or their cognate receptors in Schwann cell development has been established. We have found that Schwann cells isolated from postna…
View article: Induction of Postnatal Schwann Cell Death by the Low-Affinity Neurotrophin Receptor<i>In Vitro</i>and after Axotomy
Induction of Postnatal Schwann Cell Death by the Low-Affinity Neurotrophin Receptor<i>In Vitro</i>and after Axotomy Open
Schwann cells express the low-affinity neurotrophin receptor (p75), but no role for either the neurotrophins or their cognate receptors in Schwann cell development has been established. We have found that Schwann cells isolated from postna…
View article: Nerve Growth Factor Signaling through p75 Induces Apoptosis in Schwann Cells via a Bcl-2-Independent Pathway
Nerve Growth Factor Signaling through p75 Induces Apoptosis in Schwann Cells via a Bcl-2-Independent Pathway Open
Apoptosis is involved in the regulation of Schwann cell numbers during normal development and after axonal damage, but the molecular regulation of Schwann cell death remains unknown. We have used stably transfected rat Schwann cell lines t…
A Role for Insulin-Like Growth Factor-I in the Regulation of Schwann Cell Survival Open
During postnatal development in the peripheral nerve, differentiating Schwann cells are susceptible to apoptotic death. Schwann cell apoptosis is regulated by axons and serves as one mechanism through which axon and Schwann cell numbers ar…
Cell death in the Schwann cell lineage and its regulation by neuregulin. Open
The development of Schwann cells, the myelin-forming glial cells of the vertebrate peripheral nervous system, involves a neonatal phase of proliferation in which cells migrate along and segregate newly formed axons. Withdrawal from the cel…
The Transcription Factors SCIP and Krox-20 Mark Distinct Stages and Cell Fates in Schwann Cell Differentiation Open
We have studied the transcription factors SCIP and Krox-20 in differentiating Schwann cells-during normal development, in experimentally induced degenerating and regenerating peripheral nerves, and in cell culture-and have compared the exp…
Upstream interactions of functional mammalian tRNA gene transcription complexes probed using a heterologous DNA-binding protein. Open
An oligonucleotide containing the recognition site for the Escherichia coli lac repressor was inserted at various positions in the 5' flanking region of a human serine tRNA gene, and the consequences of binding lac repressor on in vitro tr…
The 5' flanking sequence negatively modulates the in vivo expression and in vitro transcription of a human tRNA gene Open
The consequences of altering the 5' flanking region of a human amber suppressor tRNA(ser) gene on phenotypic expression in vivo and transcription in vitro was examined by constructing a series of upstream deletion and substitution mutants.…
Regulated Expression of a Mammalian Nonsense Suppressor tRNA Gene In Vivo and In Vitro Using the <i>lac</i> Operator/Repressor System Open
We have exploited the Escherichia coli lac operator/repressor system as a means to regulate the expression of a mammalian tRNA gene in vivo and in vitro. An oligonucleotide containing a lac operator (lacO) site was cloned immediately upstr…