Daniel E. Weeks
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View article: Study protocol for the Health Outcomes in Pregnancy and Early Childhood (HOPE) Study: A mother-infant study in American Samoa
Study protocol for the Health Outcomes in Pregnancy and Early Childhood (HOPE) Study: A mother-infant study in American Samoa Open
Pacific Islanders, including those in American Samoa, face a disproportionately high burden of gestational diabetes mellitus (GDM) and related sequalae of metabolic conditions. The CREBRF rs373863828 genetic variant, which is uniquely comm…
View article: Allostatic Load Mediates Associations Between Race and Ethnicity and Hypertensive Disorders of Pregnancy
Allostatic Load Mediates Associations Between Race and Ethnicity and Hypertensive Disorders of Pregnancy Open
OBJECTIVE: To evaluate whether chronic stress exposure, measured by allostatic load (a biological measure of chronic stress embodiment, including stressors exacerbated by structural inequities [eg, structural racism]) and patient-reported …
View article: A Genome-Wide Association Study of Anti-Müllerian Hormone (AMH) Levels in Samoan Women
A Genome-Wide Association Study of Anti-Müllerian Hormone (AMH) Levels in Samoan Women Open
Background/Objectives:The anti-Müllerian hormone (AMH) is a key biomarker of the ovarian reserve, correlating with ovarian follicle count, fertility outcomes, and menopause timing. Understanding its genetic determinants has broad implicati…
View article: A Genome-Wide Association Study of Anti-Müllerian Hormone (AMH) Levels in Samoan Women
A Genome-Wide Association Study of Anti-Müllerian Hormone (AMH) Levels in Samoan Women Open
Background/Objectives: The anti-Müllerian hormone (AMH) is a key biomarker of the ovarian reserve, correlating with ovarian follicle count, fertility outcomes, and menopause timing. Understanding its genetic determinants has broad implicat…
View article: Differential DNA Methylation of the Brain-Derived Neurotrophic Factor Gene is Observed after Pediatric Traumatic Brain Injury Compared to Orthopedic Injury
Differential DNA Methylation of the Brain-Derived Neurotrophic Factor Gene is Observed after Pediatric Traumatic Brain Injury Compared to Orthopedic Injury Open
Importance Pediatric traumatic brain injury (TBI) triggers biological changes that may differ from those observed in non-brain injuries. BDNF DNA methylation (DNAm) may serve as a novel, dynamic biomarker of the brain’s response and help i…
View article: Study Protocol for the Health Outcomes in Pregnancy and Early Childhood (HOPE) Study: A Mother-Infant Study in American Samoa
Study Protocol for the Health Outcomes in Pregnancy and Early Childhood (HOPE) Study: A Mother-Infant Study in American Samoa Open
Introduction Pacific Islanders, including those in American Samoa, face a disproportionately high burden of gestational diabetes mellitus (GDM) and related sequalae of metabolic conditions. The CREBRF rs373863828 genetic variant, which is …
View article: Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele
Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele Open
Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study lev…
View article: A genome-wide association study of anti-Müllerian hormone (AMH) levels in Samoan women
A genome-wide association study of anti-Müllerian hormone (AMH) levels in Samoan women Open
Study question Can a genome-wide association study (GWAS) and transcriptome-wide association study (TWAS) help identify genetic variation or genes associated with circulating anti-Müllerian hormone (AMH) levels in Samoan women? Summary ans…
View article: Associations between DNA methylation and cognitive function in early-stage hormone receptor-positive breast cancer patients
Associations between DNA methylation and cognitive function in early-stage hormone receptor-positive breast cancer patients Open
Background Approximately one-third of breast cancer (BC) patients show poorer cognitive function (CF) before receiving adjuvant therapy compared with age-matched healthy controls. However, the biological mechanisms driving CF variation in …
View article: Multivariate Bayesian Analyses in Nursing Research: An Introductory Guide
Multivariate Bayesian Analyses in Nursing Research: An Introductory Guide Open
In the era of precision health, nursing research has increasingly focused on the analysis of large, multidimensional data sets containing multiple correlated phenotypes (e.g., symptoms). This presents challenges for statistical analyses, e…
View article: Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort
Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort Open
Background The A allele of rs373863828 in CREB3 regulatory factor is associated with high Body Mass Index, but lower odds of type 2 diabetes. These associations have been replicated elsewhere, but to date all studies have been cross-sectio…
View article: Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program
Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program Open
The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied mostly through genome arrays, resulting in over 100 associated variants. We extended this work with high-coverage whole genome sequencing analyses …
View article: Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential
Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential Open
Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies. Clonal hematopoiesis of indeterminate…
View article: Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing
Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing Open
Most transcriptome-wide association studies (TWASs) so far focus on European ancestry and lack diversity. To overcome this limitation, we aggregated genome-wide association study (GWAS) summary statistics, whole-genome sequences and expres…
View article: Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed
Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed Open
Genetic studies on telomere length are important for understanding age-related diseases. Prior GWASs for leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study for TL …
View article: Characterization of per- and polyfluoroalkyl substances (PFAS) concentrations in a community-based sample of infants from Samoa
Characterization of per- and polyfluoroalkyl substances (PFAS) concentrations in a community-based sample of infants from Samoa Open
Per- and polyfluoroalkyl substances (PFAS) are persistent contaminants with documented harmful health effects. Despite increasing research, little attention has been given to studying PFAS contamination in low- and middle-income countries,…
View article: A system for phenotype harmonization in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) program
A system for phenotype harmonization in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) program Open
Genotype-phenotype association studies often combine phenotype data from multiple studies to increase statistical power. Harmonization of the data usually requires substantial effort due to heterogeneity in phenotype definitions, study des…
View article: Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension
Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension Open
Background: The availability of whole-genome sequencing data in large studies has enabled the assessment of coding and noncoding variants across the allele frequency spectrum for their associations with blood pressure. Methods: We conducte…
View article: A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies
A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies Open
Large-scale whole-genome sequencing studies have enabled analysis of noncoding rare-variant (RV) associations with complex human diseases and traits. Variant-set analysis is a powerful approach to study RV association. However, existing me…
View article: Characterization of sleep apnea among a sample of adults from Samoa
Characterization of sleep apnea among a sample of adults from Samoa Open
Sleep apnea is a public health concern around the world, but little research has been dedicated to examining this issue in low- and middle-income countries, including Samoa. Using data collected through the Soifua Manuia (“Good Health”) st…
View article: Characterization of Per- and Polyfluoroalkyl Substance (PFAS) concentrations in a community-based sample of infants from Samoa
Characterization of Per- and Polyfluoroalkyl Substance (PFAS) concentrations in a community-based sample of infants from Samoa Open
Per- and polyfluoroalkyl substances (PFAS) are persistent contaminants with documented harmful health effects. Despite increasing research, little attention has been given to studying PFAS contamination in low- and middle-income countries,…
View article: The<i>Soifua Manuia</i>reference panel with 2,570 Samoan haplotypes improves genotype imputation quality among Samoans
The<i>Soifua Manuia</i>reference panel with 2,570 Samoan haplotypes improves genotype imputation quality among Samoans Open
Genotype imputation is fundamental to association studies, and yet even gold standard panels like TOPMed are limited in the populations for which they yield good imputation. Specifically, Pacific Islanders are poorly represented in extant …
View article: WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE
WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE Open
Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study lev…
View article: A Polynesian-specific missense CETP variant alters the lipid profile
A Polynesian-specific missense CETP variant alters the lipid profile Open
Identifying population-specific genetic variants associated with disease and disease-predisposing traits is important to provide insights into the genetic determinants of health and disease between populations, as well as furthering genomi…