Daniel Edmonston
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View article: Concordance With Screening and Treatment Guidelines for Chronic Kidney Disease in Type 2 Diabetes
Concordance With Screening and Treatment Guidelines for Chronic Kidney Disease in Type 2 Diabetes Open
Importance Chronic kidney disease (CKD) is an often-asymptomatic complication of type 2 diabetes (T2D) that requires annual screening to diagnose. Patient-level factors linked to inadequate screening and treatment can inform implementation…
View article: Plasma Serotonin and Cardiovascular Outcomes in Chronic Kidney Disease
Plasma Serotonin and Cardiovascular Outcomes in Chronic Kidney Disease Open
Background Platelet‐poor plasma serotonin levels are associated with adverse cardiovascular outcomes. Although plasma serotonin levels increase in chronic kidney disease, the cardiovascular implications remain unknown. Methods and Results …
View article: Sildenafil and Kidney Function in Heart Failure with Preserved Ejection Fraction
Sildenafil and Kidney Function in Heart Failure with Preserved Ejection Fraction Open
Key Points Sildenafil induced an acute effect on eGFR without change in the overall eGFR slope after 24 weeks in a heart failure with preserved ejection fraction (HFpEF) cohort. N -terminal pro–brain natriuretic peptide levels and baseline…
View article: Association of Surge Conditions with Mortality Among Critically Ill Patients with COVID-19
Association of Surge Conditions with Mortality Among Critically Ill Patients with COVID-19 Open
Objective To determine whether surge conditions were associated with increased mortality. Design Multicenter cohort study. Setting U.S. ICUs participating in STOP-COVID. Patients Consecutive adults with COVID-19 admitted to participating I…
View article: Hospital-Level Variation in Death for Critically Ill Patients with COVID-19
Hospital-Level Variation in Death for Critically Ill Patients with COVID-19 Open
There is considerable interhospital variation in mortality for critically ill patients with COVID-19, which is mostly explained by hospital-level socioeconomic status, strain, and acute physiologic differences. Individual mortality is driv…
View article: Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19
Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19 Open
None.
View article: Design and Rationale of HiLo: A Pragmatic, Randomized Trial of Phosphate Management for Patients Receiving Maintenance Hemodialysis
Design and Rationale of HiLo: A Pragmatic, Randomized Trial of Phosphate Management for Patients Receiving Maintenance Hemodialysis Open
Registered at ClinicalTrials.gov with study number NCT04095039.
View article: Prescribing rates and characteristics of recipients of tenofovir-containing regimens before and after market entry of tenofovir alafenamide
Prescribing rates and characteristics of recipients of tenofovir-containing regimens before and after market entry of tenofovir alafenamide Open
BACKGROUND: Tenofovir alafenamide (TAF) is a new formulation of tenofovir disoproxil fumarate (TDF) that was approved in 2015. While clinical trial evidence suggests that TAF has more favorable outcomes related to kidney injury and loss of…
View article: Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19
Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19 Open
Among critically ill patients with COVID-19 in this cohort study, the risk of in-hospital mortality in this study was lower in patients treated with tocilizumab in the first 2 days of ICU admission compared with patients whose treatment di…
View article: Echocardiography to Screen for Pulmonary Hypertension in CKD
Echocardiography to Screen for Pulmonary Hypertension in CKD Open
The optimal model to predict PH diagnosis included TRV, right atrial pressure, and TAPSE. Since TAPSE more strongly associated with PH in the CKD population, these findings support a CKD-specific approach to the development of noninvasive …
View article: Randomized elimination and prolongation of ACE inhibitors and ARBs in coronavirus 2019 (REPLACE COVID) Trial Protocol
Randomized elimination and prolongation of ACE inhibitors and ARBs in coronavirus 2019 (REPLACE COVID) Trial Protocol Open
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus responsible for coronavirus disease 2019 (COVID‐19), is associated with high incidence of multiorgan dysfunction and death. Angiotensin‐converting enzyme 2 (ACE2), whi…
View article: Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US
Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US Open
This study identified demographic, clinical, and hospital-level risk factors that may be associated with death in critically ill patients with COVID-19 and can facilitate the identification of medications and supportive therapies to improv…
View article: Good Guys, Bad Guys, Guesses, and Near Misses in Nephrology
Good Guys, Bad Guys, Guesses, and Near Misses in Nephrology Open
From seemingly out of nowhere, inhibitors of sodium-glucose cotransporter 2 (SGLT2) stand poised to revolutionize the care of patients with CKD. No clinical practitioner, scientific investigator, pharmaceutical developer, or biotechnology …
View article: Statins at Dialysis Transition—Supportive but Not Sufficient
Statins at Dialysis Transition—Supportive but Not Sufficient Open
Elani Streja, MPH, PhD; Elvira O. Gosmanova, MD; Miklos Z. Molnar, MD, PhD; Melissa Soohoo, MPH; Hamid Moradi, MD; Praveen K. Potukuchi, MS; Kamyar Kalantar-Zadeh, MD, MPH, PhD; Csaba P. Kovesdy, MD
View article: The emerging role of novel antihyperglycemic agents in the treatment of heart failure and diabetes: A focus on cardiorenal outcomes
The emerging role of novel antihyperglycemic agents in the treatment of heart failure and diabetes: A focus on cardiorenal outcomes Open
Heart failure (HF) and type 2 diabetes mellitus (T2DM) are two global pandemics, affecting over 25 and 420 million people, respectively. The prevalence of comorbid HF and T2DM is rising, and the prognosis remains poor. One central area of …