Daniel F. Levey
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View article: Multi-ancestry investigation of the genomics of erectile dysfunction
Multi-ancestry investigation of the genomics of erectile dysfunction Open
Erectile dysfunction is attributable to numerous biological and psychological issues, and its prevalence increases with age. We conducted genome-wide association studies of erectile dysfunction in AllofUs subjects of European and African a…
View article: Multi-ancestry epigenome wide association study of generalized anxiety disorder
Multi-ancestry epigenome wide association study of generalized anxiety disorder Open
Epigenetic studies face persistent challenges related to small sample sizes, particularly when using epigenome-wide array technologies. Presumably it is this limitation that has hindered the discovery of replicable and robust findings, muc…
View article: The genetics of cannabis lifetime use
The genetics of cannabis lifetime use Open
Cannabis is one of the most commonly used drugs in the world, and use is trending alarmingly higher. We aimed to examine the genetic basis of cannabis lifetime use (CanLU) and its genetic relationships with a variety of psychiatric- and ph…
View article: DNA Methylation Signatures of Alcohol Use Disorder – A large-scale Meta-Analysis in the Psychiatric Genomics Consortium
DNA Methylation Signatures of Alcohol Use Disorder – A large-scale Meta-Analysis in the Psychiatric Genomics Consortium Open
Despite extensive research on DNA methylation (DNAm) signatures associated with alcohol use disorder (AUD), findings are often inconsistent and not replicated. We conducted a large-scale meta-analysis of epigenome-wide association studies …
View article: Genetics of SSRI antidepressant use and relationship to psychiatric and medical traits
Genetics of SSRI antidepressant use and relationship to psychiatric and medical traits Open
Antidepressants are among the most-prescribed drugs worldwide, and selective serotonin reuptake inhibitors (SSRIs) are among the most prescribed antidepressants, most commonly used for major depression. We sought to increase our understand…
View article: A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies
A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies Open
Strong sex differences exist in sleep phenotypes and also cardiovascular diseases (CVDs). However, sex-specific causal effects of sleep phenotypes on CVD-related outcomes have not been thoroughly examined. Mendelian randomization (MR) anal…
View article: 656. GENETIC INSIGHTS INTO CANNABIS USE AND USE DISORDER
656. GENETIC INSIGHTS INTO CANNABIS USE AND USE DISORDER Open
Background Cannabis use has gained legal and societal acceptance in many locations worldwide in recent years, with consequent increases in both cannabis lifetime use (CanLU) and cannabis use disorder (CanUD). Both CanLU and CanUD are genet…
View article: A contextual genomic perspective on physical activity and its relationship to health, well being and illness
A contextual genomic perspective on physical activity and its relationship to health, well being and illness Open
View article: Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD Open
View article: The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders
The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders Open
Increasing prevalence of cannabis use and cannabis use disorder (CanUD) may increase risk for psychiatric disorders. We evaluated the relationships between these cannabis traits and a range of psychiatric traits, running global and local g…
View article: Multi-ancestry genetic architecture of sleep duration and its relationship to other sleep and psychiatric phenotypes
Multi-ancestry genetic architecture of sleep duration and its relationship to other sleep and psychiatric phenotypes Open
Differences in sleep duration, quality, and timing are associated with variation in cognition, health outcomes, and quality of life. Genetic studies may help explain the underlying mechanisms of sleep and its relationships to other conditi…
View article: Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality
Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality Open
Personality traits describe stable differences in how individuals think, feel, and behave and how they interact with and experience their social and physical environments. We assemble data from 46 cohorts including 611K-1.14M participants …
View article: Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder Open
View article: A contextual genomic perspective on physical activity and its relationship to health, well-being and illness
A contextual genomic perspective on physical activity and its relationship to health, well-being and illness Open
Physical activity (PA) is one of the most fundamental of all traits in the animal kingdom, has pervasive health benefits, and is genetically influenced. Using data from the Million Veteran Program (MVP), we conducted genetic analyses of le…
View article: A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies
A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies Open
Strong sex differences exist in sleep phenotypes and also cardiovascular diseases (CVDs). However, sex-specific causal effects of sleep phenotypes on CVD-related outcomes have not been thoroughly examined. Mendelian randomization (MR) anal…
View article: Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology
Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology Open
Background There is considerable comorbidity between externalizing (EXT) and internalizing (INT) psychopathology. Understanding the shared genetic underpinnings of these spectra is crucial for advancing knowledge of their biological bases …
View article: Differences and similarities between the genetic architecture of lifetime substance use across different substances
Differences and similarities between the genetic architecture of lifetime substance use across different substances Open
Background Illicit drug use may lead to dependence on those drugs, is associated with various psychiatric disorders, and can have hazardous, sometimes life-threatening, consequences. We investigated the genetic architecture underlying the …
View article: Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology
Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology Open
Background The Hierarchical Taxonomy of Psychopathology (HiTOP) and Research Domain Criteria (RDoC) frameworks emphasize transdiagnostic and mechanistic aspects of psychopathology. We used a multi-omics approach to examine how HiTOP’s psyc…
View article: Opioid use disorder and brain health: observational and genetic associations
Opioid use disorder and brain health: observational and genetic associations Open
Background The long-term impact of opioid use disorder (OUD) on brain health has been little explored although of potentially high public health importance. Objectives To investigate the potential causal impact of OUD on later life brain h…
View article: Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts
Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts Open
BACKGROUND: Post-traumatic stress disorder (PTSD) and depression are common after mild traumatic brain injury (mTBI), but their biological drivers are uncertain. We therefore explored whether polygenic risk scores (PRS) derived for PTSD an…
View article: Examining Methylation at the Intersection of Genetic Risk To Alzheimer’s Disease And Alcohol Use Disorder
Examining Methylation at the Intersection of Genetic Risk To Alzheimer’s Disease And Alcohol Use Disorder Open
Background Alcohol Use Disorder (AUD) affects over 15 million individuals in the United States, contributing to oxidative stress, neuroinflammation, and elevating the risk of neurodegeneration. Despite this, the connection between AUD and …
View article: Examining Methylation at the Intersection of Genetic Risk To Alzheimer's Disease And Alcohol Use Disorder
Examining Methylation at the Intersection of Genetic Risk To Alzheimer's Disease And Alcohol Use Disorder Open
Background Alcohol Use Disorder (AUD) affects over 15 million individuals in the United States, contributing to oxidative stress, neuroinflammation, and elevating the risk of neurodegeneration. Despite this, the connection between AUD and …
View article: Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction
Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction Open
Myasthenia gravis (MG) is a rare autoantibody-mediated disease affecting the neuromuscular junction. We performed a genome-wide association study of 5708 MG cases and 432,028 controls of European ancestry and a replication study in 3989 ca…
View article: 720 Fc-enhanced anti-CTLA-4 antibody, botensilimab<sup>ms</sup>, enhances the efficacy of multiple therapeutic modalities in immunotherapy-refractory tumor models
720 Fc-enhanced anti-CTLA-4 antibody, botensilimab<sup>ms</sup>, enhances the efficacy of multiple therapeutic modalities in immunotherapy-refractory tumor models Open
View article: Epigenetic and Genetic Profiling of Comorbidity Patterns among Substance Dependence Diagnoses
Epigenetic and Genetic Profiling of Comorbidity Patterns among Substance Dependence Diagnoses Open
Objective This study investigated the genetic and epigenetic mechanisms underlying the comorbidity patterns of five substance dependence diagnoses (SDs; alcohol, AD; cannabis, CaD; cocaine, CoD; opioid, OD; tobacco, TD). Methods A latent c…
View article: Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study
Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study Open
Background Cannabis use during adolescence and young adulthood has been associated with brain harm, yet despite a rapid increase in cannabis use among older adults in the past decade, the impact on brain health in this population remains u…
View article: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology Open
View article: Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated blood–brain barrier opening: A novel combinatorial immunotherapy regimen for gliomas
Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated blood–brain barrier opening: A novel combinatorial immunotherapy regimen for gliomas Open
Background Glioblastoma is a highly aggressive brain cancer that is resistant to conventional immunotherapy strategies. Botensilimab, an Fc-enhanced anti-CTLA-4 antibody (FcE-aCTLA-4), has shown durable activity in “cold” and immunotherapy…
View article: Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program Open
One of the justifiable criticisms of human genetic studies is the underrepresentation of participants from diverse populations. Lack of inclusion must be addressed at-scale to identify causal disease factors and understand the genetic caus…
View article: Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling Open
The major anxiety disorders (ANX; including generalized anxiety disorder, panic disorder, and phobias ) are highly prevalent, often onset early, persist throughout life, and cause substantial global disability. Although distinct in their c…