Daniel G. Fuster
YOU?
Author Swipe
View article: Renal Metabolic Defects in Patients with Recurrent Unilateral Nephro- and Ureterolithiasis: Insights from Individual Renal Unit Sampling
Renal Metabolic Defects in Patients with Recurrent Unilateral Nephro- and Ureterolithiasis: Insights from Individual Renal Unit Sampling Open
Background and Objective: Urolithiasis is a highly prevalent condition influenced by environmental, dietary, and genetic factors. Recurrent unilateral stone formation raises the question of whether localized renal metabolic abnormalities c…
View article: A homology-based 3D model and structure–function studies reveal key elements for divalent metal ion transporter ZIP8 (SLC39A8) function
A homology-based 3D model and structure–function studies reveal key elements for divalent metal ion transporter ZIP8 (SLC39A8) function Open
The divalent metal transporter ZIP8 (SLC39A8) plays a pivotal role in maintaining the homeostasis of essential micronutrients such as manganese (Mn2+), zinc (Zn2+) and iron (Fe2+). Genetic variants of SLC39…
View article: Correction: SMART stone multidisciplinary team (MDT) and patient care: recommendations for the adult high-risk kidney stone patient pathway
Correction: SMART stone multidisciplinary team (MDT) and patient care: recommendations for the adult high-risk kidney stone patient pathway Open
View article: Partial volume effect on kidney stones and lung nodules in CT imaging
Partial volume effect on kidney stones and lung nodules in CT imaging Open
Rationale and Objectives To examine the impact of the partial volume effect (PVE) on the imaging of spherical objects depending on their size, density and center voxel position. Materials and Methods We developed an algorithm for calculati…
View article: Natural History of Advanced Primary Hyperoxaluria Type 1: A Retrospective Study
Natural History of Advanced Primary Hyperoxaluria Type 1: A Retrospective Study Open
View article: High-salt diet modulates endocrine regulation between cortisol and FGF23
High-salt diet modulates endocrine regulation between cortisol and FGF23 Open
Excessive dietary salt intake is a global health concern, affecting cardiovascular, renal, and bone health. While the renin-angiotensin-aldosterone system (RAAS) is a known regulator of dietary salt-induced hormonal responses, the impact o…
View article: Incidental findings on non-contrast abdominal computed tomography in an asymptomatic population: Prevalence, economic and health implications
Incidental findings on non-contrast abdominal computed tomography in an asymptomatic population: Prevalence, economic and health implications Open
Introduction Increasing use of low-dose abdominal computed tomography (CT) scans in clinical diagnostics and research offers high sensitivity for kidney stones with minimal radiation exposure. However, due to reduced specificity, incidenta…
View article: Indapamide or chlorthalidone to reduce urine supersaturation for secondary prevention of kidney stones: protocol for a randomised, double-blind, cross-over trial (INDAPACHLOR)
Indapamide or chlorthalidone to reduce urine supersaturation for secondary prevention of kidney stones: protocol for a randomised, double-blind, cross-over trial (INDAPACHLOR) Open
Introduction Kidney stones constitute a major global healthcare problem and are characterised by high recurrence rates. Thiazide and thiazide-like diuretics (thiazides) have been the standard medical treatment for the prevention of kidney …
View article: Adenine phosphoribosyltransferase deficiency as a rare cause of rapidly progressive chronic kidney disease
Adenine phosphoribosyltransferase deficiency as a rare cause of rapidly progressive chronic kidney disease Open
View article: SMART Stone Multidisciplinary Team (MDT) and patient care: recommendations for the adult high-risk kidney stone patient pathway
SMART Stone Multidisciplinary Team (MDT) and patient care: recommendations for the adult high-risk kidney stone patient pathway Open
Purpose The SMART Stone Multidisciplinary Team (MDT) recommendations aim to provide guidance on the role of the MDT in the early identification, referral and assessment of adult high-risk recurrent kidney stone formers to advance patient c…
View article: Estimating 24-hour urine phosphate excretion from spot urine
Estimating 24-hour urine phosphate excretion from spot urine Open
Background 24-hour urinary phosphate excretion (24hUrP) is indicative of intestinal phosphate absorption in steady-state conditions. Nevertheless, 24-hour urine collections are cumbersome and error-prone. Previous studies suggested that sp…
View article: PIP2-mediated oligomerization of the endosomal sodium/proton exchanger NHE9
PIP2-mediated oligomerization of the endosomal sodium/proton exchanger NHE9 Open
View article: Acid excretion is impaired in calcium oxalate stone formers
Acid excretion is impaired in calcium oxalate stone formers Open
View article: Nephrectomy in autosomal dominant polycystic kidney disease: a consensus statement of the ERA Genes & Kidney Working Group
Nephrectomy in autosomal dominant polycystic kidney disease: a consensus statement of the ERA Genes & Kidney Working Group Open
A substantial number of patients with autosomal dominant polycystic kidney disease (ADPKD) undergo a nephrectomy, especially in workup for a kidney transplantation. Currently, there is no evidence-based algorithm to guide clinicians about …
View article: Changes in CD4+ T cells subsets in patients with alcohol-related cirrhosis
Changes in CD4+ T cells subsets in patients with alcohol-related cirrhosis Open
Alcohol-related cirrhosis (AC) is a condition that impacts in immunity. We analyzed changes over time in CD4 + subsets in AC-patients. We included patients with alcohol use disorder admitted at least twice for treatment. Patients without e…
View article: Empagliflozin in nondiabetic individuals with calcium and uric acid kidney stones: a randomized phase 2 trial
Empagliflozin in nondiabetic individuals with calcium and uric acid kidney stones: a randomized phase 2 trial Open
View article: Changes in CD4 + T-cells subsets in patients with alcohol-related cirrhosis
Changes in CD4 + T-cells subsets in patients with alcohol-related cirrhosis Open
Alcohol-related cirrhosis (AC) is a condition that impacts in immunity. We analyzed changes over time in CD4+subsets in AC-patients. We included patients with alcohol use disorder admitted at least twice for treatment. Patients …
View article: Risk Factors of Asymptomatic Kidney Stone Passage in Adults with Recurrent Kidney Stones
Risk Factors of Asymptomatic Kidney Stone Passage in Adults with Recurrent Kidney Stones Open
Key Points Asymptomatic stone passage was common in patients with recurrent calcium-containing kidney stones. Higher the number of stones at presentation, more likely it was that a kidney stone would spontaneously pass over time without ca…
View article: Effects of thiazides and new findings on kidney stones and dysglycemic side effects
Effects of thiazides and new findings on kidney stones and dysglycemic side effects Open
Thiazide and thiazide‐like diuretics (thiazides) belong to the most frequently prescribed drugs worldwide. By virtue of their natriuretic and vasodilating properties, thiazides effectively lower blood pressure and prevent adverse cardiovas…
View article: #1472 Prevalence of Mendelian and non-Mendelian forms of genetic disease in a Swiss cohort of adult kidney stone formers
#1472 Prevalence of Mendelian and non-Mendelian forms of genetic disease in a Swiss cohort of adult kidney stone formers Open
Background and Aims Molecular mechanisms of kidney stone formation remain unknown in most patients. Previous studies showed high heritability of nephrolithiasis, but analysis of Mendelian disease in selected cohorts and genome-wide analysi…
View article: #1430 Acid excretion is disturbed in calcium oxalate and calcium phosphate stone formers in the Swiss kidney stone cohort
#1430 Acid excretion is disturbed in calcium oxalate and calcium phosphate stone formers in the Swiss kidney stone cohort Open
Background and Aims Kidney stone is a highly prevalent disease worldwide that causes high morbidity and may increase the risk for chronic kidney disease. Urine pH influences the crystallization of some types of kidney stones, such as calci…
View article: Thiazides for kidney stone recurrence prevention
Thiazides for kidney stone recurrence prevention Open
Purpose of review Kidney stones are the most common condition affecting the kidney, and characterized by a high rate of recurrence. Thiazide and thiazide-like diuretics (thiazides) are commonly prescribed to prevent the recurrence of kidne…
View article: Prevalence and characteristics of genetic disease in adult kidney stone formers
Prevalence and characteristics of genetic disease in adult kidney stone formers Open
Background Molecular mechanisms of kidney stone formation remain unknown in most patients. Previous studies have shown a high heritability of nephrolithiasis, but data on the prevalence and characteristics of genetic disease in unselected …
View article: The Vitamin D Metabolite Diagnostic Ratio Associates With Phenotypic Traits of Idiopathic Hypercalciuria
The Vitamin D Metabolite Diagnostic Ratio Associates With Phenotypic Traits of Idiopathic Hypercalciuria Open
Our study reveals that CYP24A1 activity, estimated by VMDR, is associated with clinical traits previously linked to idiopathic hypercalciuria.
View article: Routine Urinary Biochemistry Does Not Accurately Predict Stone Type Nor Recurrence in Kidney Stone Formers: A Multicentre, Multimodel, Externally Validated Machine-Learning Study
Routine Urinary Biochemistry Does Not Accurately Predict Stone Type Nor Recurrence in Kidney Stone Formers: A Multicentre, Multimodel, Externally Validated Machine-Learning Study Open
Objectives: Urinary biochemistry is used to detect and monitor conditions associated with recurrent kidney stones. There are no predictive machine learning (ML) tools for kidney stone type or recurrence. We therefore aimed to…
View article: PI-(3,5)P2-mediated oligomerization of the endosomal sodium/proton exchanger NHE9
PI-(3,5)P2-mediated oligomerization of the endosomal sodium/proton exchanger NHE9 Open
Na + /H + exchangers are found in all cells to regulate intracellular pH, sodium levels and cell volume. Na + /H + exchangers are physiological homodimers that operate by an elevator alternating-access mechanism. While the structure of the…
View article: Prevalence and characteristics of genetic disease in adult kidney stone formers
Prevalence and characteristics of genetic disease in adult kidney stone formers Open
Background Molecular mechanisms of kidney stone formation remain unknown in most patients. Previous studies showed high heritability of nephrolithiasis, but data on prevalence and characteristics of genetic disease in unselected adults wit…
View article: Differences in the Food Consumption Between Kidney Stone Formers and Nonformers in the Swiss Kidney Stone Cohort
Differences in the Food Consumption Between Kidney Stone Formers and Nonformers in the Swiss Kidney Stone Cohort Open
View article: Randomized, Double-Blind, Placebo-Controlled Crossover Trial of Once Daily Empagliflozin 25 mg for the Treatment of Postprandial Hypoglycemia After Roux-en-Y Gastric Bypass
Randomized, Double-Blind, Placebo-Controlled Crossover Trial of Once Daily Empagliflozin 25 mg for the Treatment of Postprandial Hypoglycemia After Roux-en-Y Gastric Bypass Open
Aims: To investigate the effect of empagliflozin on glucose dynamics in individuals suffering from postbariatric hypoglycemia (PBH) after Roux-en-Y gastric bypass (RYGB). Methods: Twenty-two adults with PBH afte…
View article: Thiazides Attenuate Insulin Secretion Through Inhibition of Mitochondrial Carbonic Anhydrase 5b in β-Islet Cells in Mice
Thiazides Attenuate Insulin Secretion Through Inhibition of Mitochondrial Carbonic Anhydrase 5b in β-Islet Cells in Mice Open
Significance Statement Thiazide diuretics (thiazides) are among the most widely prescribed drugs worldwide, but their use is associated with glucose intolerance and new-onset diabetes mellitus. The molecular mechanisms remain elusive. Our …