Daniel G. Dillon
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View article: Comprehensive mapping of cognitive and emotion networks in stress, anxiety, and depression implicates the precuneus as a critical hub
Comprehensive mapping of cognitive and emotion networks in stress, anxiety, and depression implicates the precuneus as a critical hub Open
Stress-related conditions disrupt cognition and emotion regulation and can result in psychiatric illness, but the neural circuit-level changes that can explain these broad effects remain unclear. To address this issue, we paired population…
View article: Identification of conserved frontal neurophysiological markers of cognitive flexibility in humans and rats
Identification of conserved frontal neurophysiological markers of cognitive flexibility in humans and rats Open
Cognitive flexibility broadly describes behavioral alterations made in response to environmental changes and is fundamental for survival. While human and non-human animal assessments of cognitive flexibility are available, a systematic cro…
View article: Heightened familiarity drives the negative retrieval bias in depression: Evidence from the PRISM task
Heightened familiarity drives the negative retrieval bias in depression: Evidence from the PRISM task Open
Major Depressive Disorder (MDD) is associated with emotional memory deficits with substantial downstream consequences, but treatment is limited by a poor understanding of the upstream mechanisms that drive such behavior. Our previous work …
View article: Heightened familiarity drives the negative retrieval bias in depression: Evidence from the PRISM task
Heightened familiarity drives the negative retrieval bias in depression: Evidence from the PRISM task Open
Major Depressive Disorder (MDD) is associated with emotional memory deficits with substantial downstream consequences, but treatment is limited by a poor understanding of the upstream mechanisms that drive such behavior. Our previous work …
View article: Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup
Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup Open
Background Identifying robust neural signatures of posttraumatic stress disorder (PTSD) symptoms is important to facilitate precision psychiatry and help in understanding and treatment of the disorder. Emergent research suggests structural…
View article: Effects of behavioral interventions on stress reactivity in adults with substance use disorders.
Effects of behavioral interventions on stress reactivity in adults with substance use disorders. Open
Results indicated that, although participants were able to implement behavioral skills following a brief training, training condition did not modify stress reactivity, on average, relative to control. Future directions include consideratio…
View article: Neural and behavioral markers of inhibitory control predict symptom improvement during internet-delivered cognitive behavioral therapy for depression
Neural and behavioral markers of inhibitory control predict symptom improvement during internet-delivered cognitive behavioral therapy for depression Open
Poor inhibitory control contributes to deficits in emotion regulation, which are often targeted by treatments for major depressive disorder (MDD), including cognitive behavioral therapy (CBT). Brain regions that contribute to inhibitory co…
View article: Using Drift Diffusion and RL Models to Disentangle Effects of Depression On Decision-Making vs. Learning in the Probabilistic Reward Task
Using Drift Diffusion and RL Models to Disentangle Effects of Depression On Decision-Making vs. Learning in the Probabilistic Reward Task Open
The Probabilistic Reward Task (PRT) is widely used to investigate the impact of Major Depressive Disorder (MDD) on reinforcement learning (RL), and recent studies have used it to provide insight into decision-making mechanisms affected by …
View article: Postnatal Phencyclidine-Induced Deficits in Decision Making Are Ameliorated by Optogenetic Inhibition of Ventromedial Orbitofrontal Cortical Glutamate Neurons
Postnatal Phencyclidine-Induced Deficits in Decision Making Are Ameliorated by Optogenetic Inhibition of Ventromedial Orbitofrontal Cortical Glutamate Neurons Open
Postnatal PCP-induced deficits in decision making are associated with hyperactivity of vmOFC glutamate cells. Thus, normalizing vmOFC activity may represent a potential therapeutic target for decision-making deficits in patients with schiz…
View article: Modulation of ventromedial orbitofrontal cortical glutamatergic activity affects the explore-exploit balance and influences value-based decision-making
Modulation of ventromedial orbitofrontal cortical glutamatergic activity affects the explore-exploit balance and influences value-based decision-making Open
The balance between exploration and exploitation is essential for decision-making. The present study investigated the role of ventromedial orbitofrontal cortex (vmOFC) glutamate neurons in mediating value-based decision-making by first usi…
View article: Altered coordination between frontal delta and parietal alpha networks underlies anhedonia and depressive rumination in major depressive disorder
Altered coordination between frontal delta and parietal alpha networks underlies anhedonia and depressive rumination in major depressive disorder Open
Background A hyperactive default mode network (DMN) has been observed in people with major depressive disorder (MDD), and weak DMN suppression has been linked to depressive symptoms. However, whether dysregulation of the DMN contributes to…
View article: Abnormal evidence accumulation underlies the positive memory deficit in depression.
Abnormal evidence accumulation underlies the positive memory deficit in depression. Open
Healthy adults show better memory for low-arousal positive versus negative stimuli, but depression compromises this positive memory advantage. Existing studies are limited by small samples or analyses that provide limited insight into unde…
View article: Striatal Dopamine Binding in Anhedonia: A Simultaneous [<sup>11</sup>C]Raclopride Positron Emission Tomography and Functional Magnetic Resonance Imaging Investigation
Striatal Dopamine Binding in Anhedonia: A Simultaneous [<sup>11</sup>C]Raclopride Positron Emission Tomography and Functional Magnetic Resonance Imaging Investigation Open
Background Anhedonia is hypothesized to be associated with blunted mesocorticolimbic dopamine (DA) functioning in samples with major depressive disorder. The purpose of this study was to examine linkages between striatal DA binding, reward…
View article: Fast evidence accumulation in social anxiety disorder enhances decision making in a probabilistic reward task.
Fast evidence accumulation in social anxiety disorder enhances decision making in a probabilistic reward task. Open
Choices and response times in two-alternative decision-making tasks can be modeled by assuming that individuals steadily accrue evidence in favor of each alternative until a response boundary for one of them is crossed, at which point that…
View article: A multi-pronged investigation of option generation using depression, PET and modafinil
A multi-pronged investigation of option generation using depression, PET and modafinil Open
Option generation is a critical process in decision making, but previous studies have largely focused on choices between options given by a researcher. Consequently, how we self-generate options for behaviour remain poorly understood. Here…
View article: A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation of striatal dopamine binding in autism
A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation of striatal dopamine binding in autism Open
The social motivation hypothesis of autism posits that autism spectrum disorder (ASD) is characterized by impaired motivation to seek out social experience early in life that interferes with the development of social functioning. This fram…
View article: Behavioral strategies to reduce stress reactivity in opioid use disorder: Study design.
Behavioral strategies to reduce stress reactivity in opioid use disorder: Study design. Open
The ultimate goal of this study is to inform the development of behavioral interventions that can be used as an adjunct to medication-based treatment for opioid use disorder. (PsycInfo Database Record (c) 2020 APA, all rights reserved).