Daniel G. Hackam
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View article: Regression of carotid atherosclerosis in high‐risk individuals with proprotein convertase subtilisin/kexin type 9 inhibitors
Regression of carotid atherosclerosis in high‐risk individuals with proprotein convertase subtilisin/kexin type 9 inhibitors Open
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors represent a novel approach for reducing cholesterol and, accordingly, the burden of atherosclerosis. However, limited data are available regarding the possible effects of PCS…
View article: Association Between Stroke and Subsequent Risk of Suicide
Association Between Stroke and Subsequent Risk of Suicide Open
Background and Purpose: Poor mental health and depression are well-recognized sequelae of stroke; however, the association between stroke and subsequent risk of suicide is unknown. Methods: We systematically searched MEDLINE, Embase, PsycI…
View article: Vitamin B<sub><sub>12</sub></sub>deficiency and hyperhomocysteinaemia in outpatients with stroke or transient ischaemic attack: a cohort study at an academic medical centre
Vitamin B<sub><sub>12</sub></sub>deficiency and hyperhomocysteinaemia in outpatients with stroke or transient ischaemic attack: a cohort study at an academic medical centre Open
Objective We sought to assess the current magnitude of the opportunity for secondary stroke prevention with B vitamins. Design A cohort study. Setting The Urgent TIA (Transient Ischaemic Attack) Clinic at an academic medical centre. Main o…
View article: Decline in the Severity of Carotid Atherosclerosis and Associated Risk Factors From 2002 to 2014
Decline in the Severity of Carotid Atherosclerosis and Associated Risk Factors From 2002 to 2014 Open
Background and Purpose— Several recent studies suggest declining rates of carotid revascularization for patients with carotid stenosis. We investigated whether carotid atherosclerosis severity has declined in recent years. Methods— We used…
View article: Effects of eplerenone on resistance to antihypertensive medication in patients with primary or secondary hyperaldosteronism
Effects of eplerenone on resistance to antihypertensive medication in patients with primary or secondary hyperaldosteronism Open
Background and Objectives Resistant hypertension is an important problem; nearly half of diagnosed hypertensives are not controlled to target blood pressure levels, and approximately 90% of strokes occur among patients with resistant hyper…
View article: Physiological Phenotyping for Personalized Therapy of Uncontrolled Hypertension in Africa
Physiological Phenotyping for Personalized Therapy of Uncontrolled Hypertension in Africa Open
OBJECTIVES African and African American hypertensives tend to retain salt and water, with lower levels of plasma renin and more resistant hypertension. We tested the hypothesis that physiological phenotyping with plasma renin and aldostero…
View article: High Frequency of Variants of Candidate Genes in Black Africans with Low Renin-Resistant Hypertension
High Frequency of Variants of Candidate Genes in Black Africans with Low Renin-Resistant Hypertension Open
OBJECTIVES Black subjects tend to retain salt and water, be more sensitive to aldosterone, and have suppression of plasma renin activity. Variants of the renal sodium channel (ENaC, SCNN1B) account for approximately 6% of resistant hyperte…
View article: Antiepileptic drugs and hyponatremia in older adults: Two population‐based cohort studies
Antiepileptic drugs and hyponatremia in older adults: Two population‐based cohort studies Open
Summary Objective To examine the 30‐day risk of hospitalization with hyponatremia associated with carbamazepine, valproic acid (V), phenytoin (P), or topiramate (T) use compared to nonuse in the outpatient setting among older adults. Metho…
View article: Prognosis of Asymptomatic Carotid Artery Occlusion
Prognosis of Asymptomatic Carotid Artery Occlusion Open
Background and Purpose— The aim of this systematic review was to quantify the risk of ipsilateral stroke in patients with asymptomatic carotid artery occlusion (ACAO). Methods— Studies reporting ipsilateral stroke risk in ACAO were identif…
View article: Macrolide antibiotics and the risk of ventricular arrhythmia in older adults
Macrolide antibiotics and the risk of ventricular arrhythmia in older adults Open
Among older adults, macrolide antibiotics were not associated with a higher 30-day risk of ventricular arrhythmia than nonmacrolide antibiotics. These findings suggest that current warnings from the US Food and Drug Administration may be o…
View article: Atypical Antipsychotic Medications and Hyponatremia in Older Adults: A Population-Based Cohort Study
Atypical Antipsychotic Medications and Hyponatremia in Older Adults: A Population-Based Cohort Study Open
Background: A number of case reports have suggested a possible association between atypical antipsychotic medications and hyponatremia. Currently, there are no reliable estimates of hyponatremia risk from atypical antipsychotic drugs. Obje…
View article: Supplementary Material for: Lost Productivity in Stroke Survivors: An Econometrics Analysis
Supplementary Material for: Lost Productivity in Stroke Survivors: An Econometrics Analysis Open
Background: Stroke leads to a substantial societal economic burden. Loss of productivity among stroke survivors is a significant contributor to the indirect costs associated with stroke. We aimed to characterize productivity and factors as…
View article: Supplementary Material for: Lost Productivity in Stroke Survivors: An Econometrics Analysis
Supplementary Material for: Lost Productivity in Stroke Survivors: An Econometrics Analysis Open
Background: Stroke leads to a substantial societal economic burden. Loss of productivity among stroke survivors is a significant contributor to the indirect costs associated with stroke. We aimed to characterize productivity and factors as…
View article: Declining Incidence of Stroke and Dementia: Coincidence or Prevention Opportunity?
Declining Incidence of Stroke and Dementia: Coincidence or Prevention Opportunity? Open
This longitudinal population-based study explores trends in declining dementia rates using health care administrative data from the Canadian Institute for Health Information for the province of Ontario, Canada.