Daniel Gabriel Pons
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View article: Hotspot mutant p53-R273H enhances mitochondrial biogenesis and cell migration in primary colorectal cancer in response to oxaliplatin
Hotspot mutant p53-R273H enhances mitochondrial biogenesis and cell migration in primary colorectal cancer in response to oxaliplatin Open
Oxaliplatin is commonly known as a successful chemotherapy for advanced colorectal cancer, improving patient survival and eradicating micro-metastases, but its use in early stages remains controversial. Mitochondria fuel energy-intensive p…
View article: Active Substances from the Micro-Immunotherapy Medicine 2LMIREG Display Antioxidative Properties In Vitro in Two Colorectal Cancer Cell Lines
Active Substances from the Micro-Immunotherapy Medicine 2LMIREG Display Antioxidative Properties In Vitro in Two Colorectal Cancer Cell Lines Open
Mitochondria play a crucial role in oxidative stress control and reactive oxygen species (ROS) generation, impacting many cellular processes. Dysregulated mitochondria are linked to diseases such as colorectal cancer (CRC), known for its a…
View article: A Conceptual Model-Based Application for the Treatment and Management of Data in Pediatric Oncology: The Neuroblastoma Use Case
A Conceptual Model-Based Application for the Treatment and Management of Data in Pediatric Oncology: The Neuroblastoma Use Case Open
View article: Oxidative Phosphorylation as a Predictive Biomarker of Oxaliplatin Response in Colorectal Cancer
Oxidative Phosphorylation as a Predictive Biomarker of Oxaliplatin Response in Colorectal Cancer Open
Oxaliplatin is successfully used on advanced colorectal cancer to eradicate micro-metastasis, whereas its benefits in the early stages of colorectal cancer remains controversial since approximately 30% of patients experience unexpected rel…
View article: Tumorspheres as In Vitro Model for Identifying Predictive Chemoresistance and Tumor Aggressiveness Biomarkers in Breast and Colorectal Cancer
Tumorspheres as In Vitro Model for Identifying Predictive Chemoresistance and Tumor Aggressiveness Biomarkers in Breast and Colorectal Cancer Open
Chemoresistance remains a major challenge in the treatment of breast and colorectal cancer. For this reason, finding reliable predictive biomarkers of response to chemotherapy has become a significant research focus in recent years. Howeve…
View article: Roles of Phytochemicals in Cancer Prevention and Therapeutics
Roles of Phytochemicals in Cancer Prevention and Therapeutics Open
This Special Issue focused on the importance of phytochemicals for their use in the prevention and treatment of cancer [...]
View article: Metformin: From Diabetes to Cancer—Unveiling Molecular Mechanisms and Therapeutic Strategies
Metformin: From Diabetes to Cancer—Unveiling Molecular Mechanisms and Therapeutic Strategies Open
Metformin, a widely used anti-diabetic drug, has garnered attention for its potential in cancer management, particularly in breast and colorectal cancer. It is established that metformin reduces mitochondrial respiration, but its specific …
View article: Metformin: From Diabetes to Cancer—Unveiling Molecular Mechanisms and Therapeutic Strategies
Metformin: From Diabetes to Cancer—Unveiling Molecular Mechanisms and Therapeutic Strategies Open
Metformin, a widely used anti-diabetic drug, has garnered attention for its potential in cancer management, particularly in breast and colorectal cancer. It is established that metformin reduces mitochondrial respiration, but its specific …
View article: A quantum expectation identity: Applications to statistical mechanics
A quantum expectation identity: Applications to statistical mechanics Open
In this article we derive a useful expectation identity using the language of quantum statistical mechanics, where density matrices represent the state of knowledge about the system. This identity allows to establish relations between diff…
View article: Mitochondrial Functionality Is Regulated by Alkylphospholipids in Human Colon Cancer Cells
Mitochondrial Functionality Is Regulated by Alkylphospholipids in Human Colon Cancer Cells Open
Alkylphospholipids (APLs) have been studied as anticancer drugs that interfere with biological membranes without targeting DNA. Although their mechanism of action is not fully elucidated yet, it is known that they disrupt the intracellular…
View article: Sublethal doses of glyphosate modulates mitochondria and oxidative stress in honeybees by direct feeding
Sublethal doses of glyphosate modulates mitochondria and oxidative stress in honeybees by direct feeding Open
Honeybees are essential for the ecosystem maintenance and for plant production in agriculture. Glyphosate is a broad‐spectrum systemic herbicide widely used in crops to control weeds and could affect honeybees' health in sublethal doses. O…
View article: Isolation and Characterization of Extracellular Vesicles in Human Bowel Lavage Fluid
Isolation and Characterization of Extracellular Vesicles in Human Bowel Lavage Fluid Open
Colorectal cancer (CRC) is the third most common cancer worldwide and is detected in late stages because of a lack of early and specific biomarkers. Tumors can release extracellular vesicles (EVs), which participate in different functions,…
View article: Inflammation-Related Signature Profile Expression as a Poor Prognosis Marker after Oxaliplatin Treatment in Colorectal Cancer
Inflammation-Related Signature Profile Expression as a Poor Prognosis Marker after Oxaliplatin Treatment in Colorectal Cancer Open
Oxaliplatin is successfully used to eradicate micro-metastasis and improve survival, whereas the benefit of adjuvant chemotherapy in the early stages of colorectal cancer remains controversial. Inflammation plays a crucial role in colorect…
View article: Inflammation- and Metastasis-Related Proteins Expression Changes in Early Stages in Tumor and Non-Tumor Adjacent Tissues of Colorectal Cancer Samples
Inflammation- and Metastasis-Related Proteins Expression Changes in Early Stages in Tumor and Non-Tumor Adjacent Tissues of Colorectal Cancer Samples Open
Chronic inflammation can induce malignant cell transformation, having an important role in all colorectal cancer (CRC) phases. Non-tumor adjacent tissue plays an important role in tumor progression, but its implication in CRC has not yet b…
View article: High Concentrations of Genistein Decrease Cell Viability Depending on Oxidative Stress and Inflammation in Colon Cancer Cell Lines
High Concentrations of Genistein Decrease Cell Viability Depending on Oxidative Stress and Inflammation in Colon Cancer Cell Lines Open
Genistein could play a crucial role in modulating three closely linked physiological processes altered during cancer: oxidative stress, mitochondrial biogenesis, and inflammation. However, genistein’s role in colorectal cancer remains uncl…
View article: Mitochondrial Function Differences between Tumor Tissue of Human Metastatic and Premetastatic CRC
Mitochondrial Function Differences between Tumor Tissue of Human Metastatic and Premetastatic CRC Open
Most colorectal cancer (CRC) patients die as a consequence of metastasis. Mitochondrial dysfunction could enhance cancer development and metastatic progression. We aimed to evaluate the adaptations associated with mitochondrial function in…
View article: Use of Omics Technologies for the Detection of Colorectal Cancer Biomarkers
Use of Omics Technologies for the Detection of Colorectal Cancer Biomarkers Open
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers with high mortality rates, especially when detected at later stages. Early detection of CRC can substantially raise the 5-year survival rate of patients, and different…
View article: Estrogen Receptor Beta (ERβ) Maintains Mitochondrial Network Regulating Invasiveness in an Obesity-Related Inflammation Condition in Breast Cancer
Estrogen Receptor Beta (ERβ) Maintains Mitochondrial Network Regulating Invasiveness in an Obesity-Related Inflammation Condition in Breast Cancer Open
Obesity, a physiological situation where different proinflammatory cytokines and hormones are secreted, is a major risk factor for breast cancer. Mitochondrial functionality exhibits a relevant role in the tumorigenic potential of a cancer…
View article: Therapeutic Potential of Isoflavones with an Emphasis on Daidzein
Therapeutic Potential of Isoflavones with an Emphasis on Daidzein Open
Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual‐directional purpose by substituting/hindering with est…
View article: Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits Open
Genistein is an isoflavone first isolated from the brooming plant Dyer’s Genista tinctoria L. and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein exerts estrogen‐like functions. Several biological effect…
View article: Micronutrients Selenomethionine and Selenocysteine Modulate the Redox Status of MCF-7 Breast Cancer Cells
Micronutrients Selenomethionine and Selenocysteine Modulate the Redox Status of MCF-7 Breast Cancer Cells Open
Selenium is a micronutrient which is found in many foods, with redox status modulation activity. Our aim was to evaluate the effects of two chemical forms of selenoamino acids, Seleno-L-methionine and Seleno-L-cystine (a diselenide derived…
View article: Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications
Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications Open
View article: Mutant p53 induces SIRT3/MnSOD axis to moderate ROS production in melanoma cells
Mutant p53 induces SIRT3/MnSOD axis to moderate ROS production in melanoma cells Open
View article: Sirtuin 3 silencing impairs mitochondrial biogenesis and metabolism in colon cancer cells
Sirtuin 3 silencing impairs mitochondrial biogenesis and metabolism in colon cancer cells Open
Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase and targets several crucial enzymes against oxidative stress. Recent reports suggest that SIRT3 could also participate in the quality and quantity control of mitochondria. The aim of …
View article: SIRT3 Silencing Sensitizes Breast Cancer Cells to Cytotoxic Treatments Through an Increment in ROS Production
SIRT3 Silencing Sensitizes Breast Cancer Cells to Cytotoxic Treatments Through an Increment in ROS Production Open
SIRT3, the major deacetylase in mitochondria, plays a crucial role modulating ROS production and scavenging by regulating key proteins implicated in mitochondrial turnover and in antioxidant defenses. Therefore, SIRT3 could confer resistan…
View article: UCP2 inhibition sensitizes breast cancer cells to therapeutic agents by increasing oxidative stress
UCP2 inhibition sensitizes breast cancer cells to therapeutic agents by increasing oxidative stress Open