Daniel G. Di Luca
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View article: Revisiting the 2015 MDS diagnostic criteria for Parkinson disease: insights from autopsy-confirmed cases
Revisiting the 2015 MDS diagnostic criteria for Parkinson disease: insights from autopsy-confirmed cases Open
The 2015 International Parkinson and Movement Disorder Society (MDS) Diagnostic criteria for Parkinson Disease are based on expert consensus opinion and defines core motor features, ‘Absolute Exclusion Criteria’ and a balance of ‘Supportiv…
View article: Determining Falls Risk in People with Parkinson’s Disease Using Wearable Sensors: A Systematic Review
Determining Falls Risk in People with Parkinson’s Disease Using Wearable Sensors: A Systematic Review Open
A prior history of falls remains the strongest predictor of future falls in individuals with Parkinson’s disease (PD). There are limited biomarkers available to identify falls risk before falls begin to occur. The aim of this review is to …
View article: Clinical and Imaging Correlates of Medication Reduction in Globus Pallidus Stimulation for Parkinson's Disease
Clinical and Imaging Correlates of Medication Reduction in Globus Pallidus Stimulation for Parkinson's Disease Open
Background The magnitude and factors associated with levodopa equivalent daily dose (LEDD) reduction in deep brain stimulation (DBS) of the globus pallidus interna (GPi) for Parkinson's Disease (PD) remain unclear. Objective To investigate…
View article: Multimodal oculomotor assessment reveals prodromal markers of Parkinson’s disease in non-manifesting LRRK2 G2019S mutation carriers
Multimodal oculomotor assessment reveals prodromal markers of Parkinson’s disease in non-manifesting LRRK2 G2019S mutation carriers Open
Oculomotor behaviour changes in patients with Parkinson's disease (PD) are a promising source of prodromal disease markers. Capitalizing on this phenomenon to facilitate early diagnosis requires oculomotor assessment in prodromal cohorts. …
View article: Exposure to Glycolysis-Enhancing Drugs and Risk of Parkinson’s Disease: A Meta-Analysis
Exposure to Glycolysis-Enhancing Drugs and Risk of Parkinson’s Disease: A Meta-Analysis Open
Background: Impaired glucose and energy metabolism has been suggested as a pathogenic mechanism underlying Parkinson’s disease (PD). In recent cohorts, phosphoglycerate kinase 1 activators (PGK1a) have been associated with a lower incidenc…
View article: How Do I Examine Laryngeal Dystonia?
How Do I Examine Laryngeal Dystonia? Open
Laryngeal dystonia is a potentially disabling task specific dystonia primarily affecting speech. The evaluation and diagnosis of laryngeal dystonia remain challenging, and often require a multi‐disciplinary approach, involving collaboratio…
View article: Plasticity‐Induced Effects of Theta Burst Transcranial Ultrasound Stimulation in Parkinson's Disease
Plasticity‐Induced Effects of Theta Burst Transcranial Ultrasound Stimulation in Parkinson's Disease Open
Background Low‐intensity transcranial ultrasound stimulation (TUS) is a noninvasive brain stimulation (NIBS) technique with high spatial specificity. Previous studies showed that TUS delivered in a theta burst pattern (tbTUS) increased mot…
View article: Neurophobia: challenges and solutions
Neurophobia: challenges and solutions Open
T he unfavorable attitude toward neurology, a phenomenon commonly referred to as neurophobia, is prevalent among medical students and junior doctors at times in their medical education. Professor Ralph Jozefowicz, in 1994, coined the term …
View article: Multiple system atrophy with amyloid-β-predominant Alzheimer’s disease neuropathologic change
Multiple system atrophy with amyloid-β-predominant Alzheimer’s disease neuropathologic change Open
Multiple system atrophy is a neurodegenerative disease with α-synuclein pathology predominating in the striatonigral and olivopontocerebellar systems. Mixed pathologies are considered to be of low frequency and mostly comprise primary age-…
View article: Arm Swing while Walking and Running: A New Clinical Feature to Separate Parkinson's Disease from Functional Parkinsonism
Arm Swing while Walking and Running: A New Clinical Feature to Separate Parkinson's Disease from Functional Parkinsonism Open
Background Functional parkinsonism is an important differential diagnosis of Parkinson's disease (PD). Based on anecdotal experience, we hypothesized that arm swing while walking and running could differentiate these two conditions, but th…
View article: How to Peer Review a Neurology Education Manuscript
How to Peer Review a Neurology Education Manuscript Open
Peer review is an essential process in scientific research, ensuring the comprehensiveness, accuracy, and suitability of manuscripts for publication. Neurology education research differs from biomedical clinical research in several ways. T…
View article: Deep Brain Stimulation of the Globus Pallidus Internus and Externus in Multiple System Atrophy
Deep Brain Stimulation of the Globus Pallidus Internus and Externus in Multiple System Atrophy Open
Background Multiple system atrophy with parkinsonism (MSA‐P) is a progressive condition with no effective treatment. Objective The aim of this study was to describe the safety and efficacy of deep brain stimulation (DBS) of globus pallidus…
View article: A Phase Ib, Double Blind, Randomized Study of Cannabis Oil for Pain in Parkinson's Disease
A Phase Ib, Double Blind, Randomized Study of Cannabis Oil for Pain in Parkinson's Disease Open
Background Pain is common in Parkinson's disease (PD), but effective therapies are limited. Objectives To determine the maximum tolerated dose (MTD) and safety of formulations of delta‐9‐tetrahydrocannabinol (THC) and cannabidiol (CBD) for…
View article: Racial and Ethnic Differences in Health-Related Quality of Life for Individuals With Parkinson Disease Across Centers of Excellence
Racial and Ethnic Differences in Health-Related Quality of Life for Individuals With Parkinson Disease Across Centers of Excellence Open
There were differences in PD outcomes across racial and ethnic groups, even after adjustment for sex, disease duration, HY stage, age, and some comorbid conditions. Most notably, there was worse HRQoL among non-White patients when compared…
View article: Isolated Dystonia as an Initial Presentation of <scp>GDAP2</scp>‐Related Disorder
Isolated Dystonia as an Initial Presentation of <span>GDAP2</span>‐Related Disorder Open
Variants in the ganglioside induced differentiation associated protein 2 (GDAP2) gene cause a rare subtype of autosomal recessive cerebellar ataxia (1; Online Mendelian Inheritance in Man 618369). Here we report an individual with a unique…
View article: Enrollment of Participants From Marginalized Racial and Ethnic Groups
Enrollment of Participants From Marginalized Racial and Ethnic Groups Open
This study used data from The Safety, Tolerability, and Efficacy Assessment of Isradipine for Parkinson Disease (STEADY-PD III; NCT02168842) and the Study of Urate Elevation in Parkinson's Disease (SURE-PD3; NCT02642393).
View article: Periodic Limb Movements while Awake (<scp><i>PLMA</i></scp>) as a Manifestation of <scp>Wearing‐Off</scp> in Parkinson's Disease: A Case Series and Review of the Literature
Periodic Limb Movements while Awake (<span><i>PLMA</i></span>) as a Manifestation of <span>Wearing‐Off</span> in Parkinson's Disease: A Case Series and Review of the Literature Open
Background Periodic limb movements while awake (PLMA) are similar to Periodic limb movements in sleep (PLMS) but occurring during wakefulness and seen in association with restless leg syndrome (RLS). Objectives To describe PLMA as a wearin…
View article: <scp>MPTP</scp> Parkinsonism and Implications for Understanding Parkinson's Disease
<span>MPTP</span> Parkinsonism and Implications for Understanding Parkinson's Disease Open
Langston JW, Ballard P, Tetrud JW, Irwin I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983;219:979–980. In 1983, Langston et al first reported chronic parkinsonism in individuals following self…
View article: Dream Enactment Behavior Disorder Associated with Pallido‐Nigro‐Luysian Degeneration and Tau Proteinopathy
Dream Enactment Behavior Disorder Associated with Pallido‐Nigro‐Luysian Degeneration and Tau Proteinopathy Open
Background Pallido‐nigro‐luysian atrophy (PNLA) is a rare neurodegenerative disorder with only a few cases reported to date. Although the clinical picture usually resembles progressive supranuclear palsy, pathological examination reveals m…
View article: Is clinical assessment enough? Moving towards early differentiation of neurodegenerative parkinsonisms
Is clinical assessment enough? Moving towards early differentiation of neurodegenerative parkinsonisms Open
This scientific commentary refers to ‘Identification of multiple system atrophy mimicking Parkinson’s disease or progressive supranuclear palsy’ by Miki et al. (doi:10.1093/brain/awab017).
View article: Teaching Video NeuroImages: Reflexive movement in brain death
Teaching Video NeuroImages: Reflexive movement in brain death Open
A 49-year-old woman found in cardiac arrest at home was resuscitated after 30 minutes. Brain CT revealed diffuse anoxic injury. After 72 hours of targeted temperature management, brainstem examination, EEG, and apnea testing were consisten…