Gerhard Prager
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N-terminal pro B-type natriuretic peptide increase after bariatric surgery is linked to decreased insulin resistance and is more pronounced in women Open
Our data suggest a link between the NT-proBNP increase and reduced hyperinsulinemia following bariatric surgery, offering new insights into mechanisms underlying this frequent postoperative finding.
View article: UDFF and Auto pSWE accurately assess liver steatosis and fibrosis risk in obese patients with MASLD
UDFF and Auto pSWE accurately assess liver steatosis and fibrosis risk in obese patients with MASLD Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) can progress to fibrosis and cirrhosis. Fibrosis and steatosis assessment with vibration-controlled transient elastography (VCTE) and controlled attenuation parameter (CAP) r…
Progression of liver fibrosis after metabolic bariatric surgery in a MASLD rat model Open
Fibrosis progression occurred only in rats after moderate gastric bypass, maintained on the FFC diet, despite weight loss and histological improvement in steatosis and inflammation. Further research is needed to better understand the mecha…
A direct effect of the hematocrit on blood glucose: Evidence from hypoxia- and erythropoietin-treated mice Open
Blood glucose is lower in mountain dwellers living under low partial oxygen pressure. We show that obese mice maintained under hypoxia exhibit a delayed but distinct decrease in blood glucose with improved insulin sensitivity, which is ind…
Health Status and Patients’ Satisfaction on the Long Term after Metabolic/Bariatric Surgery Open
Introduction: Bone fractures and vitamin deficiencies are potential long-term risks after metabolic/bariatric surgery (MBS). This study aimed to evaluate the health status of patients with an average follow-up of 15 years after MBS, focusi…
View article: The effect of long-chain n-3 PUFA on liver transcriptome in human obesity
The effect of long-chain n-3 PUFA on liver transcriptome in human obesity Open
Obesity increases the risk of diseases like atherosclerotic- cardiovascular disease, type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease (MASLD). Omega-3 polyunsaturated fatty acids (n-3 PUFA) are known fo…
Role of obesity-management medications before and after metabolic bariatric surgery: a systematic review Open
Metabolic bariatric surgery (MBS) induces weight loss through a complex interplay of mechanisms, including alterations in humoral and neural signals in the gut–brain axis, bile acid metabolism pathways, and gut microbiota1. However, weight…
View article: Development of the International Federation for Surgery of Obesity and Metabolic Disorders-European Chapter (IFSO-EC) Grade-Based Guidelines on the Surgical Treatment of Obesity Using Multimodal Strategies: Design and Methodological Aspects
Development of the International Federation for Surgery of Obesity and Metabolic Disorders-European Chapter (IFSO-EC) Grade-Based Guidelines on the Surgical Treatment of Obesity Using Multimodal Strategies: Design and Methodological Aspects Open
Background: The prevalence of obesity is already a worldwide health concern. The development of straightforward guidelines regarding the whole available armamentarium (i.e., medical, endoscopic, and surgical interventions in conjunction wi…
The deep abdominal ultrasound transducer (<span>DAX</span>) increases the success rate and diagnostic accuracy of shear wave elastography for liver fibrosis assessment in patients with obesity—A prospective biopsy‐controlled study Open
Summary Background Obesity impacts the diagnostic accuracy of shear wave elastography (SWE). A deep abdominal ultrasound transducer (DAX) capable of point (pSWE) and two‐dimensional (2D)‐SWE has recently been introduced to address this iss…
Outcome of Gastric Bypass Surgery on Patients with Polycystic Ovary Syndrome: A Review Open
Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is associated with obesity. The most effective method to achieve and maintain long-term weight loss is by the Roux-en-Y gastric bypass (RYGB…
The Performance of Opioid-Free Anesthesia for Bariatric Surgery in Clinical Practice Open
Purpose Opioid-free anesthesia (OFA) is an alternative to conventional opioid-based anesthesia (OBA) in patients undergoing bariatric surgery. Several small studies and a meta-analysis have suggested advantages of OFA for bariatric surgery…
View article: Impact of Bariatric Surgery on the Stability of the Genetic Material, Oxidation, and Repair of DNA and Telomere Lengths
Impact of Bariatric Surgery on the Stability of the Genetic Material, Oxidation, and Repair of DNA and Telomere Lengths Open
Obesity causes genetic instability, which plays a key-role in the etiology of cancer and aging. We investigated the impact of bariatric surgery (BS) on DNA repair, oxidative DNA damage, telomere lengths, alterations of antioxidant enzymes …