Daniel Grasso
YOU?
Author Swipe
View article: Type I Interferons Differentially Modulate Autophagy to Shape Gemcitabine Response in Pancreatic Cancer Cells
Type I Interferons Differentially Modulate Autophagy to Shape Gemcitabine Response in Pancreatic Cancer Cells Open
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by poor prognosis and limited response to gemcitabine, the standard first-line chemotherapy. One major contributor to chemoresistance is autophagy, a process…
View article: Oncogenic stress response mechanisms as new therapeutic targets in cancer treatment: A review
Oncogenic stress response mechanisms as new therapeutic targets in cancer treatment: A review Open
Activation of oncogenes, such as through mutations in Kirsten rat sarcoma viral oncogene homolog (KRAS), triggers profound disruptions in cellular homeostasis that set off a cascade of stress responses. These responses enable cells to cope…
View article: KRAS Inhibition Reverses Chemotherapy Resistance Promoted by Therapy-Induced Senescence-like in Pancreatic Ductal Adenocarcinoma
KRAS Inhibition Reverses Chemotherapy Resistance Promoted by Therapy-Induced Senescence-like in Pancreatic Ductal Adenocarcinoma Open
Background Emerging evidence suggests that chemotherapy can accumulate senescent-like cells within tumor tissues, a phenomenon linked to therapy resistance. The aim of this study is to analyze the senescence-like state of after-treatment p…
View article: SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancer
SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancer Open
Aberrant activation of the Hedgehog (Hh) signaling pathway, through which the GLI family of transcription factors (TF) is stimulated, is commonly observed in cancer cells. One well-established mechanism of this increased activity is throug…
View article: Supplementary Figure 2 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Figure 2 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 232K, Predicted pathways regulated by Nupr1.
View article: Supplementary Figure 3 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Figure 3 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 192K, Nupr1 is required to maintain DNA repair activity in response to hypoxia and glucose starvation.
View article: Data from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Data from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
Purpose: The limited supply of oxygen and nutrients is thought to result in rigorous selection of cells that will eventually form the tumor.Experimental Design: Nupr1 expression pattern was analyzed in human tissue microarray (TMA) and cor…
View article: Supplementary Figure 3 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Figure 3 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 192K, Nupr1 is required to maintain DNA repair activity in response to hypoxia and glucose starvation.
View article: Supplementary Figure 5 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Figure 5 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 137K, Protective role of Nupr1 and AURKA in BxPC-3 cells.
View article: Supplementary Figure 6 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Figure 6 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 231K, Protective role of Nupr1 and AURKA on MiaPaCa2 cells in control experiment using additional siRNA sequences.
View article: Supplementary Figure 4 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Figure 4 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 222K, Protective role of Nupr1 and AURKA in Panc-1 cells.
View article: Supplementary Figure Legend from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Figure Legend from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 61K.
View article: Supplementary Figure 2 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Figure 2 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 232K, Predicted pathways regulated by Nupr1.
View article: Supplementary Figure 4 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Figure 4 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 222K, Protective role of Nupr1 and AURKA in Panc-1 cells.
View article: Supplementary Figure 5 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Figure 5 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 137K, Protective role of Nupr1 and AURKA in BxPC-3 cells.
View article: Supplementary Figure 6 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Figure 6 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 231K, Protective role of Nupr1 and AURKA on MiaPaCa2 cells in control experiment using additional siRNA sequences.
View article: Supplementary Table 1 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Table 1 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 57K, siRNA sequences used for silencing Nupr1, Beclin1, ATG5 and AURKA mRNA and Primer sequences used to amplify human genes.
View article: Data from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Data from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
Purpose: The limited supply of oxygen and nutrients is thought to result in rigorous selection of cells that will eventually form the tumor.Experimental Design: Nupr1 expression pattern was analyzed in human tissue microarray (TMA) and cor…
View article: Supplementary Figure 1 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Figure 1 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 355K, mRNA expression in glucose starvation- and hypoxia-treated pancreatic cancer cells expressing or not Nupr1.
View article: Supplementary Figure 1 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Figure 1 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 355K, mRNA expression in glucose starvation- and hypoxia-treated pancreatic cancer cells expressing or not Nupr1.
View article: Supplementary Table 1 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Table 1 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 57K, siRNA sequences used for silencing Nupr1, Beclin1, ATG5 and AURKA mRNA and Primer sequences used to amplify human genes.
View article: Supplementary Figure Legend from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Supplementary Figure Legend from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death Open
PDF file, 61K.
View article: Sesquiterpene Lactones as Promising Candidates for Cancer Therapy: Focus on Pancreatic Cancer
Sesquiterpene Lactones as Promising Candidates for Cancer Therapy: Focus on Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease which confers to patients a poor prognosis at short term. PDAC is the fourth leading cause of death among cancers in the Western world. The rate of new cases of pancrea…
View article: Editorial: New Roles of Autophagy Pathways in Cancer
Editorial: New Roles of Autophagy Pathways in Cancer Open
EDITORIAL article Front. Oncol., 07 July 2021Sec. Molecular and Cellular Oncology Volume 11 - 2021 | https://doi.org/10.3389/fonc.2021.726989
View article: Autophagy in Human T-Cell Leukemia Virus Type 1 (HTLV-1) Induced Leukemia
Autophagy in Human T-Cell Leukemia Virus Type 1 (HTLV-1) Induced Leukemia Open
Viruses play an important role in the development of certain human cancers. They are estimated to contribute 16% to all human cancers. Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus to be discovered and is the e…
View article: Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis
Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis Open
Mitophagy and zymophagy are selective autophagy pathways early induced in acute pancreatitis that may explain the mild, auto limited, and more frequent clinical presentation of this disease. Adequate mitochondrial bioenergetics is necessar…
View article: Autophagy-Mediated Exosomes as Immunomodulators of Natural Killer Cells in Pancreatic Cancer Microenvironment
Autophagy-Mediated Exosomes as Immunomodulators of Natural Killer Cells in Pancreatic Cancer Microenvironment Open
Pancreas ductal adenocarcinoma is a highly aggressive cancer with an incredible poor lifespan. Different chemotherapeutic agents’ schemes have been tested along the years without significant success. Furthermore, immunotherapy also fails t…
View article: Autophagy Regulation and Photodynamic Therapy: Insights to Improve Outcomes of Cancer Treatment
Autophagy Regulation and Photodynamic Therapy: Insights to Improve Outcomes of Cancer Treatment Open
Cancer is considered an age-related disease that, over the next 10 years, will become the most prevalent health problem worldwide. Although cancer therapy has remarkably improved in the last few decades, novel treatment concepts are needed…