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View article: Emerging therapeutic targets for cardiac hypertrophy
Emerging therapeutic targets for cardiac hypertrophy Open
To define new therapeutic avenues, more precision is required when describing changes in myocyte and heart structure/function in response to hypertrophic stimuli. Recent developments in computational modeling of hypertrophic networks, in c…
Statistical Approach to Incorporating Experimental Variability into a Mathematical Model of the Voltage-Gated Na+ Channel and Human Atrial Action Potential Open
The voltage-gated Na+ channel Nav1.5 is critical for normal cardiac myocyte excitability. Mathematical models have been widely used to study Nav1.5 function and link to a range of cardiac arrhythmias. There is growing appreciation for the …
Regulation of Cardiac Conduction and Arrhythmias by Ankyrin/Spectrin-Based Macromolecular Complexes Open
The cardiac conduction system is an extended network of excitable tissue tasked with generation and propagation of electrical impulses to signal coordinated contraction of the heart. The fidelity of this system depends on the proper spatio…
MicroRNA Biophysically Modulates Cardiac Action Potential by Direct Binding to Ion Channel Open
Background: MicroRNAs (miRs) play critical roles in regulation of numerous biological events, including cardiac electrophysiology and arrhythmia, through a canonical RNA interference mechanism. It remains unknown whether endogenous miRs mo…
Emerging therapeutic targets for cardiac arrhythmias: role of STAT3 in regulating cardiac fibroblast function Open
Introduction : Cardiac fibrosis contributes to the development of cardiovascular disease (CVD) and arrhythmia. Cardiac fibroblasts (CFs) are collagen-producing cells that regulate extracellular matrix (ECM) homeostasis. A complex signaling…
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII Open
Oxidant stress can contribute to health and disease. Here we show that invertebrates and vertebrates share a common stereospecific redox pathway that protects against pathological responses to stress, at the cost of reduced physiological p…
Challenges and Opportunities for Therapeutic Targeting of Calmodulin Kinase II in Heart Open
Heart failure remains a major health burden around the world. Despite great progress in delineation of molecular mechanisms underlying development of disease, standard therapy has not advanced at the same pace. The multifunctional signalin…
Computational tools for automated histological image analysis and quantification in cardiac tissue Open
Image processing and quantification is a routine and important task across disciplines in biomedical research. Understanding the effects of disease on the tissue and organ level often requires the use of images, however the process of inte…
Correction: Defining new mechanistic roles for α II spectrin in cardiac function. Open
VOLUME 294 (2019) PAGES 9576–9591 The middle initial for Georges Daoud was inadvertently omitted. The correct author list is shown above. Download .pdf (10.3 MB) Help with pdf files
βIV-Spectrin/STAT3 complex regulates fibroblast phenotype, fibrosis, and cardiac function Open
Increased fibrosis is a characteristic remodeling response to biomechanical and neurohumoral stress and a determinant of cardiac mechanical and electrical dysfunction in disease. Stress-induced activation of cardiac fibroblasts (CFs) is a …
Defining new mechanistic roles for αII spectrin in cardiac function Open
Spectrins are cytoskeletal proteins essential for membrane biogenesis and regulation and serve critical roles in protein targeting and cellular signaling. αII spectrin (SPTAN1) is one of two α spectrin genes and αII spectrin dysfunction is…
Protein Phosphatase 2A Regulates Cardiac Na <sup>+</sup> Channels Open
Rationale: Voltage-gated Na + channel ( I Na ) function is critical for normal cardiac excitability. However, the Na + channel late component ( I Na,L ) is directly associated with potentially fatal forms of congenital and acquired human a…
View article: Synchronization of Pacemaking in the Sinoatrial Node: A Mathematical Modeling Study
Synchronization of Pacemaking in the Sinoatrial Node: A Mathematical Modeling Study Open
Computational studies using mathematical models of the sinoatrial node (SAN) cardiac action potential (AP) have provided important insight into the fundamental nature of cell excitability, cardiac arrhythmias, and potential therapies. Whil…
View article: Ca<sup>2+</sup>/calmodulin-dependent kinase II-dependent regulation of atrial myocyte late Na<sup>+</sup> current, Ca<sup>2+</sup> cycling, and excitability: a mathematical modeling study
Ca<sup>2+</sup>/calmodulin-dependent kinase II-dependent regulation of atrial myocyte late Na<sup>+</sup> current, Ca<sup>2+</sup> cycling, and excitability: a mathematical modeling study Open
Atrial fibrillation (AF) affects more than three million people per year in the United States and is associated with high morbidity and mortality. Both electrical and structural remodeling contribute to AF, but the molecular pathways under…
View article: LongQt: A cardiac electrophysiology simulation platform
LongQt: A cardiac electrophysiology simulation platform Open
Mathematical modeling has been used for over half a century to advance our understanding of cardiac electrophysiology and arrhythmia mechanisms. Notably, computational studies using mathematical models of the cardiac action potential (AP) …