Daniel Grupel
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View article: Detection of <i>Paraburkholderia</i> in Clinical Specimens Associated with Use of Nonsterile Ultrasound Gel for Percutaneous Procedures — United States, Canada, and Israel, May 2023⎯April 2025
Detection of <i>Paraburkholderia</i> in Clinical Specimens Associated with Use of Nonsterile Ultrasound Gel for Percutaneous Procedures — United States, Canada, and Israel, May 2023⎯April 2025 Open
Contaminated nonsterile ultrasound gels have been implicated in outbreaks of Burkholderia infections associated with improper infection control practices before or during percutaneous procedures. In August 2024, the Minnesota Department of…
View article: Cardiac Manifestations of <i>Mycoplasma pneumoniae</i> Infections: A Cohort Study 2007–2024
Cardiac Manifestations of <i>Mycoplasma pneumoniae</i> Infections: A Cohort Study 2007–2024 Open
Background While Mycoplasma pneumoniae (MP) infections typically present as a respiratory disease, extrapulmonary manifestations are well-documented. Historically, cardiac involvement has been considered uncommon (1%–2%); however, recent o…
View article: Postoperative antibiotic prophylaxis following cardiac implantable electronic device implantation and the risk of device infection
Postoperative antibiotic prophylaxis following cardiac implantable electronic device implantation and the risk of device infection Open
Background Cardiac implantable electronic devices (CIEDs) are essential for management cardiac arrhythmia. One of the most dismal complications is device infection that may cause significant morbidity and mortality. The current perioperati…
View article: Reemergence of <i>Brucella abortus</i>, Israel, 2021
Reemergence of <i>Brucella abortus</i>, Israel, 2021 Open
After nearly 4 decades, Brucella abortus has reemerged in Israel, triggering an outbreak across 2 dairy farms (82/137 cows affected), as well as cases in dogs and 1 human case. Despite thorough epidemiologic and genomic investigation, the …
View article: P-817. Can We Stop Taking Follow-Up Blood Cultures for <i>Brucella Melitensis</i> in Hospitalized Adults?
P-817. Can We Stop Taking Follow-Up Blood Cultures for <i>Brucella Melitensis</i> in Hospitalized Adults? Open
Background Brucella melitensis is an important zoonotic pathogen causing human disease worldwide. Blood cultures are often essential in establishing the diagnosis in hospitalized patients. The need for repeated blood cultures is well estab…
View article: Preventing Severe COVID-19 with Tixagevimab-Cilgavimab in Hematological Patients Treated with Anti-CD20 Monoclonal Antibodies: An International Multicenter Study
Preventing Severe COVID-19 with Tixagevimab-Cilgavimab in Hematological Patients Treated with Anti-CD20 Monoclonal Antibodies: An International Multicenter Study Open
T-C prophylaxis effectively prevented COVID-19 and severe-critical COVID-19 in patients with HM treated with anti-CD20 monoclonal antibodies during the early Omicron variant phase of the pandemic. Even though T-C is ineffective against cur…
View article: High rates of Dientamoeba fragilis and Blastocystis species in children’s stool but minor clinical significance
High rates of Dientamoeba fragilis and Blastocystis species in children’s stool but minor clinical significance Open
While DF and Bs are frequently detected in pediatric stool samples, their clinical significance appears to be limited.
View article: Varicella-Zoster Virus–Induced Neurologic Disease After COVID-19 Vaccination: A Multicenter Observational Cohort Study
Varicella-Zoster Virus–Induced Neurologic Disease After COVID-19 Vaccination: A Multicenter Observational Cohort Study Open
Background Early reports described an increased risk of herpes zoster following receipt of mRNA-based COVID-19 vaccines. The objective was to assess whether COVID-19 vaccine is associated with varicella-zoster virus–induced neurologic dise…
View article: An international multicenter study comparing <scp>COVID</scp>‐19 omicron outcomes in patients with hematological malignancies treated with obinutuzumab versus rituximab
An international multicenter study comparing <span>COVID</span>‐19 omicron outcomes in patients with hematological malignancies treated with obinutuzumab versus rituximab Open
Objectives Hematological malignancy (HM) patients treated with anti‐CD20 monoclonal antibodies are at higher risk for severe COVID‐19. A previous single‐center study showed worse outcomes in patients treated with obinutuzumab compared to r…
View article: 2654. International Multi-Center Study Comparing the Effect of Obinutuzumab or Rituximab Treatment in Hematological Patients on COVID-19 Outcomes During the Omicron Surge
2654. International Multi-Center Study Comparing the Effect of Obinutuzumab or Rituximab Treatment in Hematological Patients on COVID-19 Outcomes During the Omicron Surge Open
Background Hematological malignancy (HM) patients treated with anti-CD20 monoclonal antibodies are at higher risk for severe COVID-19 and adverse outcomes. A previous single-center study showed worse outcomes in patients treated with obinu…
View article: Clinical outcomes of immunomodulation therapy in immunocompromised patients with severe Covid-19 and high oxygen requirement
Clinical outcomes of immunomodulation therapy in immunocompromised patients with severe Covid-19 and high oxygen requirement Open
Background & Objective : Covid-19 disease is implicated in increased mortality among immunocompromised patients. The JAK inhibitor, baricitinib (bar), or the IL-6 inhibitor, tocilizumab (toc), demonstrated a survival benefit in patients wi…
View article: Challenging diagnosis of Mycolicibacterium cosmeticum/canariasense infection: A case report and literature review
Challenging diagnosis of Mycolicibacterium cosmeticum/canariasense infection: A case report and literature review Open
We present the case of an immunocompromised child with Mycolicibacterium cosmeticum/ canariasense infection. Our case highlights the difficulty in adequate speciation. Most isolates described in the literature were identified using 16 s-rR…
View article: Clinical characteristics of SARS-CoV-2 vaccine-related acute appendicitis
Clinical characteristics of SARS-CoV-2 vaccine-related acute appendicitis Open
With the exception of older age, the clinical characteristics of patients presenting with acute appendicitis within 21 days of receiving the SARS-CoV-2 vaccination did not differ from those of patients who presented with acute appendicitis…
View article: Public and animal health risks associated with spillover of Brucella melitensis into dairy farms
Public and animal health risks associated with spillover of Brucella melitensis into dairy farms Open
Brucellosis is a worldwide zoonosis with important public health, animal health and economic implications. Brucella melitensis , commonly associated with small ruminants, is an emerging bovine pathogen in dairy farms. We analysed all B. me…
View article: Clinical impact of the Accelerate PhenoTest® BC system on patients with Gram-negative bacteremia and high risk of antimicrobial resistance: A prospective before-after implementation study
Clinical impact of the Accelerate PhenoTest® BC system on patients with Gram-negative bacteremia and high risk of antimicrobial resistance: A prospective before-after implementation study Open
Background : The Accelerate PhenoTest® BC system (AXDX) is a novel assay for rapid bacterial identification and antimicrobial susceptibility (AST). We report an evaluation of its impact on treatment of patients with Gram-negative bacteremi…
View article: 1957. Increased short-term vaccine effectiveness of BNT162b2 with same-arm vs. cross-arm administration of sequential doses
1957. Increased short-term vaccine effectiveness of BNT162b2 with same-arm vs. cross-arm administration of sequential doses Open
Background It is unknown whether administering the second BNT162B2 vaccine dose on the cross-arm or the same arm as the first dose creates a more robust local and systemic immune response leading to favorable clinical results. We used data…
View article: Prevalence and Characteristics of Carriage of <i>Neisseria meningitidis</i> Among Young Israeli Adults
Prevalence and Characteristics of Carriage of <i>Neisseria meningitidis</i> Among Young Israeli Adults Open
Background No updated data currently exist regarding Neisseria meningitidis carriage and genomic epidemiology among young Israeli adults. Methods Oropharyngeal swabs were collected from 1801 military recruits on the day of recruitment duri…
View article: Treatment with obinutuzumab leads to worse outcomes in haematological patients diagnosed with Omicron variant <scp>COVID</scp>‐19
Treatment with obinutuzumab leads to worse outcomes in haematological patients diagnosed with Omicron variant <span>COVID</span>‐19 Open
Patients with haematological malignancies (HM) who fall prey to COVID-19, especially those receiving anti-CD20 monoclonal antibodies (mAB), are at a higher risk for complications, mortality, protracted disease, and relapse.1, 2 Anti-CD-20 …
View article: Aspergillus wound infection in an immune-competent patient – A case report
Aspergillus wound infection in an immune-competent patient – A case report Open
Background: Abdominal aspergillosis is a life-threatening, opportunistic fungal infection that mainly affects immunocompromised patients. In this report, we present a case of abdominal surgical site aspergillosis in an immunocompetent pati…
View article: The association between SARS‐CoV‐2 infection and late pregnancy loss
The association between SARS‐CoV‐2 infection and late pregnancy loss Open
SARS‐CoV‐2 vertical transmission with confirmed placental infection, confirmed by whole genome sequencing of the virus, may be a contributing factor to fetal demise.
View article: COVID-19 in a Subset of Hospitalized Children in Israel
COVID-19 in a Subset of Hospitalized Children in Israel Open
Background Most pediatric coronavirus disease 2019 (COVID-19) is mild. We assessed nationally severe COVID-19, including pediatric inflammatory multisystem syndrome (PIMS), in hospitalized children. Methods An ongoing, prospective, nationa…
View article: A 1 to 1000 SARS-CoV-2 reinfection proportion in members of a large healthcare provider in Israel: a preliminary report
A 1 to 1000 SARS-CoV-2 reinfection proportion in members of a large healthcare provider in Israel: a preliminary report Open
With more than 100 million confirmed COVID-19 cases as of March 2021, reinfection is still considered to be rare. In light of increasing reports of reinfected COVID-19 patients, the need to better understand the real risk for reinfection i…
View article: Kinetics of SARS-CoV-2 anti-s IgG after BNT162b2 vaccination
Kinetics of SARS-CoV-2 anti-s IgG after BNT162b2 vaccination Open
Deployment of the BNT162b2 mRNA Covid-19 Vaccine in Israel began in December 2020. This is a retrospective analysis of serological data, describing SARS-CoV-2 anti-S IgG kinetics in 116 Israeli healthcare workers administrated the BNT162b2…
View article: Case Report: Imported Melioidosis from Goa, India to Israel, 2018
Case Report: Imported Melioidosis from Goa, India to Israel, 2018 Open
A previously healthy young man presented with a chronic cavitary pulmonary infection that began while in Goa, India. Burkholderia pseudomallei was cultured from sputum samples. The infection fully resolved after prolonged antibiotic treatm…