Daniel Guimarães Tiezzi
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View article: PersonalizedUS: Interpretable Breast Cancer Risk Assessment with Local Coverage Uncertainty Quantification
PersonalizedUS: Interpretable Breast Cancer Risk Assessment with Local Coverage Uncertainty Quantification Open
Correctly assessing the malignancy of breast lesions identified during ultrasound examinations is crucial for effective clinical decision-making. However, the current "gold standard" relies on manual BI-RADS scoring by clinicians, often le…
View article: Copper, Zinc, and Selenium Levels During Pregnancy and Their Relationship with Pre-Eclampsia Risk: A Systematic Review
Copper, Zinc, and Selenium Levels During Pregnancy and Their Relationship with Pre-Eclampsia Risk: A Systematic Review Open
Pre-eclampsia (PE) affects about 5% of all pregnancies worldwide and is one of the leading causes of maternal and fetal morbidity and mortality. Some reports suggest that micronutrients may influence this condition, but there is no existin…
View article: PersonalizedUS: Interpretable Breast Cancer Risk Assessment with Local Coverage Uncertainty Quantification
PersonalizedUS: Interpretable Breast Cancer Risk Assessment with Local Coverage Uncertainty Quantification Open
Correctly assessing the malignancy of breast lesions identified during ultrasound examinations is crucial for effective clinical decision-making. However, the current "golden standard" relies on manual BI-RADS scoring by clinicians, often …
View article: Comparação de preparações de enxertos ósseos para tratamento de defeitos ósseos críticos em um modelo animal roedor
Comparação de preparações de enxertos ósseos para tratamento de defeitos ósseos críticos em um modelo animal roedor Open
Resumo Objetivo Embora enxertos ósseos autólogos sejam o tratamento mais utilizado para defeitos ósseos, a preparação mais eficaz ainda é obscura. Este estudo animal teve como objetivo comparar diferentes preparações de enxerto ósseo autól…
View article: Editorial: Oncoplastic surgery for breast cancer
Editorial: Oncoplastic surgery for breast cancer Open
René Aloisio da Costa Vieira1,2*Gil Facina3Daniel Guimarães Tiezzi4Cicero de Andrade Urban5Ruffo de Freitas Junior6
View article: Converging and evolving immuno-genomic routes toward immune escape in breast cancer
Converging and evolving immuno-genomic routes toward immune escape in breast cancer Open
View article: 92P Molecular/genomic profile enhances prediction of response to target therapy in HER2-positive breast cancer
92P Molecular/genomic profile enhances prediction of response to target therapy in HER2-positive breast cancer Open
The HER2+ subtype is characterized by the overexpression of the HER2 oncoprotein based on immunohistochemistry (IHC) or by ERBB2 gene amplification using in situ hybridization (ISH) techniques. Although all patients are eligible for target…
View article: Real-world data on adjuvant capecitabine after standard neoadjuvant chemotherapy for triple negative breast cancer
Real-world data on adjuvant capecitabine after standard neoadjuvant chemotherapy for triple negative breast cancer Open
Our study failed to demonstrate a survival benefit of extended capecitabine therapy in patients with TNBC with residual disease after NACT. More studies are warranted to better understand the indication of systemic treatment escalation in …
View article: Machine learning as a clinical decision support tool for diagnosing superficial peritoneal endometriosis in women with dysmenorrhea and acyclic pelvic pain
Machine learning as a clinical decision support tool for diagnosing superficial peritoneal endometriosis in women with dysmenorrhea and acyclic pelvic pain Open
Background: Superficial peritoneal endometriosis, despite being the most common type of lesion, presents the greatest challenge for non-invasive diagnosis, resulting in the majority being recognised surgically. Objective: To evaluate the p…
View article: Potential biomarkers as a predictive factor of response to primary chemotherapy in breast cancer patients
Potential biomarkers as a predictive factor of response to primary chemotherapy in breast cancer patients Open
In this study, we identified miRNAs and their potential mRNA targets that are intricately linked to primary chemotherapy response in patients with invasive ductal carcinomas. A cohort of individuals diagnosed with advanced invasive breast …
View article: Delayed diagnosis and increased mortality risk: Assessing the effects of the COVID-19 pandemic on breast cancer recurrence
Delayed diagnosis and increased mortality risk: Assessing the effects of the COVID-19 pandemic on breast cancer recurrence Open
The present study is among the first to investigate the pandemic's specific effects on breast cancer recurrence, revealing concerning delays in detection and a decrease in survival rates. Prompt diagnosis, timely treatment initiation, and …
View article: Copper Deficiency and its Relation with Preeclampsia. A Systematic Review.
Copper Deficiency and its Relation with Preeclampsia. A Systematic Review. Open
Copper Deficiency and its Relation with Preeclampsia. A Systematic Review.
View article: Taxa de cobertura mamográfica e diagnóstico precoce do câncer de mama no estado de São Paulo
Taxa de cobertura mamográfica e diagnóstico precoce do câncer de mama no estado de São Paulo Open
Taxa de cobertura mamográfica e diagnóstico precoce do câncer de mama no estado de São Paulo
View article: Impacto da pandemia do SARS-COV 2 na taxa de detecção precoce do câncer de mama no estado de São Paulo
Impacto da pandemia do SARS-COV 2 na taxa de detecção precoce do câncer de mama no estado de São Paulo Open
Impacto da pandemia do SARS-COV 2 na taxa de detecção precoce do câncer de mama no estado de São Paulo
View article: The risk of preeclampsia in pregnancy with a deficit of selenium. A systematic review
The risk of preeclampsia in pregnancy with a deficit of selenium. A systematic review Open
The risk of preeclampsia in pregnancy with a deficit of selenium. A systematic review
View article: Zinc micronutrient deficiency and its association with Preeclampsia: A Systematic Review.
Zinc micronutrient deficiency and its association with Preeclampsia: A Systematic Review. Open
Zinc micronutrient deficiency and its association with Preeclampsia: A Systematic Review.
View article: 197P Computational pathology pipeline enables quantification of intratumor heterogeneity and tumor-infiltrating lymphocyte score
197P Computational pathology pipeline enables quantification of intratumor heterogeneity and tumor-infiltrating lymphocyte score Open
Tumor mutation burden, intratumor heterogeneity and the cancer related immune infiltrate are associated with response to target and immune therapies in several cancer types. The aim of this study is to establish a computational pathology (…
View article: Machine learning can reliably predict malignancy of breast lesions based on clinical and ultrasonographic features.
Machine learning can reliably predict malignancy of breast lesions based on clinical and ultrasonographic features. Open
Purpose To establish a reliable machine learning model to predict malignancy in breast lesions identified by ultrasound and optimize the negative predictive value to minimize unnecessary biopsies. Methods We included clinical and ultrasono…
View article: Metodologia científica para estatística descritiva utilizando a linguagem R
Metodologia científica para estatística descritiva utilizando a linguagem R Open
Este artigo visa descrever os procedimentos básicos de uma análise descritiva de dados clínicos utilizando a linguagem de programação R, uma ferramenta baseada no conceito de software livre, e tem como objetivo servir como guia para pesqui…
View article: The impact of COVID-19 pandemic on outcomes of women with breast cancer recurrence
The impact of COVID-19 pandemic on outcomes of women with breast cancer recurrence Open
Purpose The COVID-19 pandemic has impacted the management of several diseases. Our goal was to assess the outcomes of women diagnosed with relapsed breast cancer during the pandemic period. Methods We evaluated a cohort of 187 women with b…
View article: Data from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment
Data from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment Open
The aggressiveness of invasive ductal carcinoma (IDC) of the breast is associated with increased IL17 levels. Studying the role of IL17 in invasive breast tumor pathogenesis, we found that metastatic primary tumor-infiltrating T lymphocyte…
View article: Supplementary Materials, Figures S1-4, Table S1 from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment
Supplementary Materials, Figures S1-4, Table S1 from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment Open
Supplementary Materials, Figures S1-4, Table S1: Supplementary materials and methods Supplementary Fig. S1. Treatment with anti-IL-17 antibodies inhibits the growth of murine TC-1 tumors. Supplementary Fig. S2. Blockade of IL-17 does not a…
View article: Data from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment
Data from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment Open
The aggressiveness of invasive ductal carcinoma (IDC) of the breast is associated with increased IL17 levels. Studying the role of IL17 in invasive breast tumor pathogenesis, we found that metastatic primary tumor-infiltrating T lymphocyte…
View article: Supplementary Materials, Figures S1-4, Table S1 from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment
Supplementary Materials, Figures S1-4, Table S1 from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment Open
Supplementary Materials, Figures S1-4, Table S1: Supplementary materials and methods Supplementary Fig. S1. Treatment with anti-IL-17 antibodies inhibits the growth of murine TC-1 tumors. Supplementary Fig. S2. Blockade of IL-17 does not a…
View article: Supplementary Tables S2-5 from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment
Supplementary Tables S2-5 from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment Open
Supplementary Tables S2-5. Supplementary Table S2. Up-regulated gene expression microarray data in IL-17 treated 67NR cells information related Figure 6. Supplementary Table S3. Down-regulated gene expression microarray data in IL-17 treat…
View article: Supplementary Tables S2-5 from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment
Supplementary Tables S2-5 from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment Open
Supplementary Tables S2-5. Supplementary Table S2. Up-regulated gene expression microarray data in IL-17 treated 67NR cells information related Figure 6. Supplementary Table S3. Down-regulated gene expression microarray data in IL-17 treat…
View article: Machine learning can reliably predict malignancy of BI-RADS 4a and 4b breast lesions based on clinical and ultrasonographic features
Machine learning can reliably predict malignancy of BI-RADS 4a and 4b breast lesions based on clinical and ultrasonographic features Open
Objective: The objectives of this study were to establish the most reliable machine learning model to predict malignancy in BI-RADS 4a and 4b breast lesions and optimize the negative predictive value to minimize unnecessary biopsies. Metho…
View article: Clinicopathological characteristics and recurrence risk in patients with ductal carcinoma in situ of the breast
Clinicopathological characteristics and recurrence risk in patients with ductal carcinoma in situ of the breast Open
Introduction: With the widespread adoption of mammographic screening for breast cancer, ductal carcinoma in situ (DCIS) has been detected more frequently. In developing countries, the prevalence of ductal carcinoma in situ is low due to th…
View article: 10-year opportunistic mammographic screening scenario in Brazil and its impact on breast cancer early detection: a nationwide population-based study
10-year opportunistic mammographic screening scenario in Brazil and its impact on breast cancer early detection: a nationwide population-based study Open
The coverage of mammographic screening for women under the SUS is far below the international guidelines. Additionally, a significant number of mammograms have been performed in non-target populations. This scenario reflects the problemati…
View article: What Do the Transcriptome and Proteome of Menstrual Blood-Derived Mesenchymal Stem Cells Tell Us about Endometriosis?
What Do the Transcriptome and Proteome of Menstrual Blood-Derived Mesenchymal Stem Cells Tell Us about Endometriosis? Open
Given the importance of menstrual blood in the pathogenesis of endometriosis and the multifunctional roles of menstrual mesenchymal stem cells (MenSCs) in regenerative medicine, this issue has gained prominence in the scientific community.…