Dániel Györffy
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View article: Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface
Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface Open
Introduction Miscarriages affect 50-70% of all gestations and 15-20% of clinically recognized pregnancies. Recurrent pregnancy loss (RPL) occurs in 1-5% of clinical pregnancies and has an enormous demographic impact. However, the etiologie…
View article: Decreased Expression of Placental Proteins in Recurrent Pregnancy Loss: Functional Relevance and Diagnostic Value
Decreased Expression of Placental Proteins in Recurrent Pregnancy Loss: Functional Relevance and Diagnostic Value Open
Miscarriages affect 50–70% of all conceptions and 15–20% of clinically recognized pregnancies. Recurrent pregnancy loss (RPL, ≥2 miscarriages) affects 1–5% of recognized pregnancies. Nevertheless, our knowledge about the etiologies and pat…
View article: Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention
Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention Open
The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinical…
View article: A Kinetic Transition Network Model Reveals the Diversity of Protein Dimer Formation Mechanisms
A Kinetic Transition Network Model Reveals the Diversity of Protein Dimer Formation Mechanisms Open
Protein homodimers have been classified as three-state or two-state dimers depending on whether a folded monomer forms before association, but the details of the folding–binding mechanisms are poorly understood. Kinetic transition networks…
View article: Molecular subclasses of preeclampsia characterized by a longitudinal maternal proteomics study: distinct biomarkers, disease pathways and options for prevention
Molecular subclasses of preeclampsia characterized by a longitudinal maternal proteomics study: distinct biomarkers, disease pathways and options for prevention Open
Objectives The heterogeneous nature of preeclampsia is a major obstacle to early screening and prevention, and a molecular taxonomy of disease is needed. We have previously identified four subclasses of preeclampsia based on first-trimeste…
View article: Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: The intersection of clinical, pathological, and high-dimensional biology studies
Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: The intersection of clinical, pathological, and high-dimensional biology studies Open
View article: Ligand-induced conformational rearrangements regulate the switch between membrane-proximal and distal functions of Rho kinase 2
Ligand-induced conformational rearrangements regulate the switch between membrane-proximal and distal functions of Rho kinase 2 Open
View article: New type of interaction between the SARAH domain of the tumour suppressor RASSF1A and its mitotic kinase Aurora A
New type of interaction between the SARAH domain of the tumour suppressor RASSF1A and its mitotic kinase Aurora A Open