Daniel H. Fine
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View article: Nonopioid vs opioid analgesics after impacted third-molar extractions
Nonopioid vs opioid analgesics after impacted third-molar extractions Open
Routine opioid prescribing after dental surgery is not supported. The results of this study confirmed the American Dental Association's recommendations that ibuprofen and acetaminophen in combination should be the first-line therapy for ac…
View article: Delayed Tooth Development and the Impaired Differentiation of Stem/Progenitor Cells in Incisors from Type 2 Diabetes Mice
Delayed Tooth Development and the Impaired Differentiation of Stem/Progenitor Cells in Incisors from Type 2 Diabetes Mice Open
Patients with diabetes mellitus (DM) have an increased risk of tooth decay caused by alterations in their tooth development and their oral environment, as well as a tendency to present with pulp infection due to compromised immune response…
View article: New Classification of Periodontal Diseases, the Obstacles Created and Opportunities for Growth
New Classification of Periodontal Diseases, the Obstacles Created and Opportunities for Growth Open
The purpose of this Editorial is to expose the gaps in the knowledge created by a decision by the World Workshop Consensus Conference (WWCC), held in 2017, which was focused on the re-classification of periodontal diseases [...]
View article: Molecular Analysis of Aggregatibacter actinomycetemcomitans ApiA, a Multi-Functional Protein
Molecular Analysis of Aggregatibacter actinomycetemcomitans ApiA, a Multi-Functional Protein Open
Aggregatibacter actinomycetemcomitans ApiA is a trimeric autotransporter outer membrane protein (Omp) that participates in multiple functions, enabling A. actinomycetemcomitans to adapt to a variety of environments. The goal of this study …
View article: Computational approaches to investigate the relationship between periodontitis and cardiovascular diseases for precision medicine
Computational approaches to investigate the relationship between periodontitis and cardiovascular diseases for precision medicine Open
View article: A Rose by Any Other Name: The Long Intricate History of Localized Aggressive Periodontitis
A Rose by Any Other Name: The Long Intricate History of Localized Aggressive Periodontitis Open
This review addresses the recent World Workshop Consensus Conference (WWCC) decision to eliminate Localized Aggressive Periodontitis (LAgP) in young adults as a distinct form of periodontitis. A “Consensus” implies widespread, if not unani…
View article: From Global to Nano: A Geographical Perspective of Aggregatibacter actinomycetemcomitans
From Global to Nano: A Geographical Perspective of Aggregatibacter actinomycetemcomitans Open
The periodontal disease pathobiont Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) may exert a range of detrimental effects on periodontal diseases in general and, more specifically, with the initiation and progression of …
View article: A Rose by Any Other Name: The Long Intricate History of Localized Aggressive Periodontitis
A Rose by Any Other Name: The Long Intricate History of Localized Aggressive Periodontitis Open
This narrative review challenges the recent World Workshop Consensus (WWC) conferences failure to classify aggressive periodontitis (AP) in young adults as distinct from adult periodontitis. Deficiencies in the consensus process, results o…
View article: Pragmatic Return to Effective Dental Infection Control through Triage and Testing (PREDICT): an observational, feasibility study to improve dental office safety
Pragmatic Return to Effective Dental Infection Control through Triage and Testing (PREDICT): an observational, feasibility study to improve dental office safety Open
Background During the COVID-19 pandemic, there was a substantial interruption of care, with patients and workers fearful to return to the dental office. As dental practice creates a highly aerosolized environment, the potential for spread …
View article: Oral microbial interactions from an ecological perspective: a narrative review
Oral microbial interactions from an ecological perspective: a narrative review Open
Landscape ecology is a relatively new field of study within the sub-specialty of ecology that considers time and space in addition to structure and function. Landscape ecology contends that both the configuration (spatial pattern) and the …
View article: Pragmatic Return to Effective Dental Infection Control through Triage and Testing (PREDICT): A feasibility study to improve dental office safety
Pragmatic Return to Effective Dental Infection Control through Triage and Testing (PREDICT): A feasibility study to improve dental office safety Open
Background The COVID-19 pandemic highlights the need for practitioners to enhance workflows to increase safety and mitigate risk. As dental practice creates a highly aerosolized environment, pre-visit testing for SARS-CoV-2 has the potenti…
View article: Oral Epithelial Cells Expressing Low or Undetectable Levels of Human Angiotensin-Converting Enzyme 2 Are Susceptible to SARS-CoV-2 Virus Infection In Vitro
Oral Epithelial Cells Expressing Low or Undetectable Levels of Human Angiotensin-Converting Enzyme 2 Are Susceptible to SARS-CoV-2 Virus Infection In Vitro Open
The oral cavity is thought to be one of the portals for SARS-CoV-2 entry, although there is limited evidence of active oral infection by SARS-CoV-2 viruses. We assessed the capacity of SARS-CoV-2 to infect and replicate in oral epithelial …
View article: Advancing oral health through practice-based research
Advancing oral health through practice-based research Open
View article: Oral Epithelial Cells Expressing Low or Undetectable Levels of Human Angiotensin-Converting Enzyme 2 are Susceptible SARS-CoV-2Virus Infection in vitro
Oral Epithelial Cells Expressing Low or Undetectable Levels of Human Angiotensin-Converting Enzyme 2 are Susceptible SARS-CoV-2Virus Infection in vitro Open
The oral cavity is thought to be one of the portals for SARS-CoV-2 entry. Because there is limited evidence of active oral infection by SARS-CoV-2 viruses, we assessed the capacity of SARS-CoV-2 to infect and replicate in oral epithelial c…
View article: The Opioid Analgesic Reduction Study (OARS) Pilot: A Double-Blind Randomized Multicenter Trial
The Opioid Analgesic Reduction Study (OARS) Pilot: A Double-Blind Randomized Multicenter Trial Open
Background: With addiction rates and opioid deaths increasing, health care providers are obligated to help stem the opioid crisis. As limited studies examine the comparative effectiveness of fixed-dose combination nonopioid analgesia to op…
View article: The Pragmatic Return to Effective Dental Infection Control Through Triage and Testing (PREDICT) Study: Protocol for a Prospective Clinical Study in the National Dental Practice–Based Research Network
The Pragmatic Return to Effective Dental Infection Control Through Triage and Testing (PREDICT) Study: Protocol for a Prospective Clinical Study in the National Dental Practice–Based Research Network Open
Background Dental practice has been greatly affected by the COVID-19 pandemic. As SARS-CoV-2 infection is transmitted by respiratory fluids, dental practice techniques, which include aerosol-generating procedures, can increase the risk of …
View article: PREDICT: Pragmatic Return to Effective Dental Infection Control through Triage and Testing, a PBRN Feasibility Study (Preprint)
PREDICT: Pragmatic Return to Effective Dental Infection Control through Triage and Testing, a PBRN Feasibility Study (Preprint) Open
BACKGROUND Dental practice has been greatly affected by the COVID-19 pandemic. As SARS-COV-2 infection is transmitted by respiratory fluids, dental practice techniques, which include aerosol-generating procedures, can increase the risk of…
View article: Impact of DHCWs’ Safety Perception on Vaccine Acceptance and Adoption of Risk Mitigation Strategies
Impact of DHCWs’ Safety Perception on Vaccine Acceptance and Adoption of Risk Mitigation Strategies Open
Objectives: To estimate the association between safety perception on vaccine acceptance and adoptions of risk mitigation strategies among dental health care workers (DHCWs). Methods: A survey was emailed to DHCWs in the New Jersey area fro…
View article: The Opioid Analgesic Reduction Study (OARS)—a comparison of opioid vs. non-opioid combination analgesics for management of post-surgical pain: a double-blind randomized clinical trial
The Opioid Analgesic Reduction Study (OARS)—a comparison of opioid vs. non-opioid combination analgesics for management of post-surgical pain: a double-blind randomized clinical trial Open
Background Everyday people die unnecessarily from opioid overdose-related addiction. Dentists are among the leading prescribers of opioid analgesics. Opioid-seeking behaviors have been linked to receipt of initial opioid prescriptions foll…
View article: Severe acute respiratory syndrome coronavirus 2 screening to augment dental office and patient safety
Severe acute respiratory syndrome coronavirus 2 screening to augment dental office and patient safety Open
View article: The Opioid Analgesic Reduction Study (OARS): A Comparison of Opioid vs. Non-Opioid Combination Analgesics for Management of Post-Surgical Pain Study Protocol for a Double-Blind Randomized Multi-Center Clinical Trial
The Opioid Analgesic Reduction Study (OARS): A Comparison of Opioid vs. Non-Opioid Combination Analgesics for Management of Post-Surgical Pain Study Protocol for a Double-Blind Randomized Multi-Center Clinical Trial Open
Background: Everyday people die unnecessarily from opioid overdose-related addiction. Dentists are among the leading prescribers of opioid analgesics. Opioid seeking behaviors have been linked to receipt of initial opioid prescr…
View article: iPSC-derived cranial neural crest-like cells can replicate dental pulp tissue with the aid of angiogenic hydrogel
iPSC-derived cranial neural crest-like cells can replicate dental pulp tissue with the aid of angiogenic hydrogel Open
The dental pulp has irreplaceable roles in maintaining healthy teeth and its regeneration is a primary aim of regenerative endodontics. This study aimed to replicate the characteristics of dental pulp tissue by using cranial neural crest (…
View article: Altered Prevalence of Pulp Diagnoses in Diabetes Mellitus Patients: A Retrospective Study
Altered Prevalence of Pulp Diagnoses in Diabetes Mellitus Patients: A Retrospective Study Open
View article: Determinants and Dynamics of SARS-CoV-2 Infection in a Diverse Population: 6-Month Evaluation of a Prospective Cohort Study
Determinants and Dynamics of SARS-CoV-2 Infection in a Diverse Population: 6-Month Evaluation of a Prospective Cohort Study Open
Background We studied risk factors, antibodies, and symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a diverse, ambulatory population. Methods A prospective cohort (n = 831) previously undiagnosed with …
View article: Ezh2 knockout in mesenchymal cells causes enamel hyper-mineralization
Ezh2 knockout in mesenchymal cells causes enamel hyper-mineralization Open
Enhancer of zeste homolog 2 (EZH2) is the catalytic core of polycomb repressive complex 2 (PRC2), which primarily methylates lysine 27 on histone H3 (H2K27me3), generating transcriptionally suppressed heterochromatin. Since EZH2 suppresses…
View article: Adaptation by Ancient Horizontal Acquisition of Butyrate Metabolism Genes in Aggregatibacter actinomycetemcomitans
Adaptation by Ancient Horizontal Acquisition of Butyrate Metabolism Genes in Aggregatibacter actinomycetemcomitans Open
There has been considerable interest in the impact of short-chain fatty acids (SCFAs) on inflammatory effects related to the microbiome. Here, we present evidence that SCFAs may also be important in disease by providing an energy source or…
View article: Dysbiosis From a Microbial and Host Perspective Relative to Oral Health and Disease
Dysbiosis From a Microbial and Host Perspective Relative to Oral Health and Disease Open
The significance of microbiology and immunology with regard to caries and periodontal disease gained substantial clinical or research consideration in the mid 1960's. This enhanced emphasis related to several simple but elegant experiments…
View article: Differential Effects of Antiseptic Mouth Rinses on SARS-CoV-2 Infectivity In Vitro
Differential Effects of Antiseptic Mouth Rinses on SARS-CoV-2 Infectivity In Vitro Open
Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) is detectable in saliva from asymptomatic individuals, suggesting a potential benefit from the use of mouth rinses to suppress viral load and reduce virus spread. Published…
View article: Trees and Roary output for Adaptation by ancient horizontal acquisition of butyrate metabolism genes in Aggregatibacter actinomycetemcomitans
Trees and Roary output for Adaptation by ancient horizontal acquisition of butyrate metabolism genes in Aggregatibacter actinomycetemcomitans Open
Supporting data for publication. Raw Trees for Figure 1 and supplementary figures 2 and 3. Roary presence absence output.
View article: Trees and Roary output for Adaptation by ancient horizontal acquisition of butyrate metabolism genes in Aggregatibacter actinomycetemcomitans
Trees and Roary output for Adaptation by ancient horizontal acquisition of butyrate metabolism genes in Aggregatibacter actinomycetemcomitans Open
Supporting data for publication. Raw Trees for Figure 1 and supplementary figures 2 and 3. Roary presence absence output.