Daniel H. Lench
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View article: Midfrontal Oscillatory Alterations During Gait Imagination and Observation in Parkinson’s Disease with Freezing of Gait
Midfrontal Oscillatory Alterations During Gait Imagination and Observation in Parkinson’s Disease with Freezing of Gait Open
Background Freezing of gait (FOG) is a debilitating motor symptom of Parkinson’s disease (PD) that reflects a breakdown in both motor automaticity and cognitive control. Cognitive strategies, such as motor imagery (gait imagination, GI) an…
View article: Neuromodulation of Cortical Control in Freezing of Gait
Neuromodulation of Cortical Control in Freezing of Gait Open
Freezing of gait (FOG) is a disabling feature of Parkinson’s Disease (PD) that results in a loss of automatic gait. Neuroimaging studies suggest that increased cortical involvement in gait is closely linked to a loss of automaticity. While…
View article: Are Standardized Tests Sensitive to Early Cognitive Change in Parkinson’s Disease?
Are Standardized Tests Sensitive to Early Cognitive Change in Parkinson’s Disease? Open
Introduction Cognitive deficits within the first years of Parkinson’s disease (PD) diagnosis are commonly reported, and progression to dementia greatly impacts independence. Identifying measures sensitive to early changes is critical for t…
View article: Reduced automaticity in freezing of gait is associated with elevated cortico-cerebellar connectivity
Reduced automaticity in freezing of gait is associated with elevated cortico-cerebellar connectivity Open
Freezing of gait (FOG) in individuals with Parkinson’s Disease is associated with a loss of gait automaticity. This loss of automaticity is demonstrated by worsening gait performance while dual tasking. Functional connectivity between the …
View article: Stem cell therapy: a new hope for stroke and traumatic brain injury recovery and the challenge for rural minorities in South Carolina
Stem cell therapy: a new hope for stroke and traumatic brain injury recovery and the challenge for rural minorities in South Carolina Open
Stroke and traumatic brain injury (TBI) are a significant cause of death and disability nationwide. Both are considered public health concerns in rural communities in the state of South Carolina (SC), particularly affecting the African Ame…
View article: Bilateral deep transcranial magnetic stimulation of motor and prefrontal cortices in Parkinson’s disease: a comprehensive review
Bilateral deep transcranial magnetic stimulation of motor and prefrontal cortices in Parkinson’s disease: a comprehensive review Open
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder characterized by both motor and non-motor symptoms, many of which are resistant to currently available treatments. Since the discovery that non-invasive transcranial magnet…
View article: Deep brain stimulation for essential tremor versus essential tremor plus: should we target the same spot in the thalamus?
Deep brain stimulation for essential tremor versus essential tremor plus: should we target the same spot in the thalamus? Open
Background Although ET is a phenomenologically heterogeneous condition, thalamic DBS appears to be equally effective across subtypes. We hypothesized stimulation sites optimized for individuals with essential tremor (ET) would differ from …
View article: Safety, tolerability and feasibility of remotely-instructed home-based transcranial direct current stimulation in children with cerebral palsy
Safety, tolerability and feasibility of remotely-instructed home-based transcranial direct current stimulation in children with cerebral palsy Open
•Remotely-instructed tDCS is safe and tolerable in children and young adults with cerebral palsy.•Participants and caregivers reported and demonstrated that at-home tDCS setup was feasible.•Results support further studies to evaluate effic…
View article: Multi-session transcutaneous auricular vagus nerve stimulation for Parkinson's disease: evaluating feasibility, safety, and preliminary efficacy
Multi-session transcutaneous auricular vagus nerve stimulation for Parkinson's disease: evaluating feasibility, safety, and preliminary efficacy Open
Background In pre-clinical animal models of Parkinson's disease (PD), vagus nerve stimulation (VNS) can rescue motor deficits and protect susceptible neuronal populations. Transcutaneous auricular vagus nerve stimulation (taVNS) has emerge…
View article: Neurodegeneration of the Globus Pallidus Internus as a Neural Correlate to Dopa-Response in Freezing of Gait
Neurodegeneration of the Globus Pallidus Internus as a Neural Correlate to Dopa-Response in Freezing of Gait Open
Background: Background: Parkinson’s disease (PD) patients who develop freezing of gait (FOG) have reduced mobility and independence. While some patients experience improvement in their FOG symptoms with dopaminergic therapies, a subset of …
View article: Disrupted Access to Therapies and Impact on Well-Being During the COVID-19 Pandemic for Children With Motor Impairment and Their Caregivers
Disrupted Access to Therapies and Impact on Well-Being During the COVID-19 Pandemic for Children With Motor Impairment and Their Caregivers Open
Objectives The aim of this study was to determine the impact of the COVID-19 pandemic on access to rehabilitation therapies and the impact of changes in therapy access on the physical and mental well-being of children with motor impairment…
View article: Determining the optimal pulse number for theta burst induced change in cortical excitability
Determining the optimal pulse number for theta burst induced change in cortical excitability Open
Theta-burst stimulation (TBS) is a form of non-invasive neuromodulation which is delivered in an intermittent (iTBS) or continuous (cTBS) manner. Although 600 pulses is the most common dose, the goal of these experiments was to evaluate th…
View article: Evaluating a novel <scp>MR‐compatible</scp> foot pedal device for unipedal and bipedal motion: <scp>Test–retest</scp> reliability of evoked brain activity
Evaluating a novel <span>MR‐compatible</span> foot pedal device for unipedal and bipedal motion: <span>Test–retest</span> reliability of evoked brain activity Open
The purpose of this study was to develop and evaluate a new, open‐source MR‐compatible device capable of assessing unipedal and bipedal lower extremity movement with minimal head motion and high test–retest reliability. To evaluate the pro…
View article: Individualized anodal transcranial direct current stimulation increases corticospinal excitability in children with hemiparesis due to early stroke: transcranial magnetic stimulation assessment data
Individualized anodal transcranial direct current stimulation increases corticospinal excitability in children with hemiparesis due to early stroke: transcranial magnetic stimulation assessment data Open
**This dataset contains 19 individuals (N01-N21, excl N10 and N18) with stroke and hemiparesis, age 7-22.
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\nData are stored in Matlab data structures, which contain a table and two sub-structures:
\n1. BasicInfo (table): demographics, …