Daniel Hagenfeld
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View article: Exhaled Carbon Monoxide Indicates Persistent Subgingival Dysbiosis After Periodontal Therapy
Exhaled Carbon Monoxide Indicates Persistent Subgingival Dysbiosis After Periodontal Therapy Open
Aim To investigate whether exhaled carbon monoxide (CO) is dose‐dependently associated with subgingival polymicrobial clusters before and after non‐surgical periodontal therapy. Material and Methods We followed 163 adults with periodontiti…
View article: Proteome‐Guided Drug Target Discovery for Periodontitis
Proteome‐Guided Drug Target Discovery for Periodontitis Open
Background and Objective Periodontitis is a chronic inflammatory disease driven by immune dysfunction and microbial imbalance. This study aims to identify circulating druggable proteins causally linked to the disease. Materials and Methods…
View article: Association of supragingival plaque management with subgingival microbiota is moderated by adjunctive antibiotics in stage III-IV periodontitis patients during periodontal therapy
Association of supragingival plaque management with subgingival microbiota is moderated by adjunctive antibiotics in stage III-IV periodontitis patients during periodontal therapy Open
Ineffective supragingival plaque control correlates with increased BOP and microbial diversity, though not necessarily with dysbiosis. Adjunctive antibiotics may promote a more cariogenic subgingival microbiota by disrupting the associatio…
View article: Impact of Prolonged Fasting on the Oral Microbiome in Patients With Metabolic Syndrome: An Exploratory Secondary Analysis
Impact of Prolonged Fasting on the Oral Microbiome in Patients With Metabolic Syndrome: An Exploratory Secondary Analysis Open
Aim To evaluate the effect of prolonged fasting on the oral microbiome in patients with metabolic syndrome (MetS). Materials and Methods This follow‐up study evaluated changes in the oral microbiome in a sub‐cohort of 42 patients with MetS…
View article: Consensus Report of the 20th European Workshop on Periodontology: Contemporary and Emerging Technologies in Periodontal Diagnosis
Consensus Report of the 20th European Workshop on Periodontology: Contemporary and Emerging Technologies in Periodontal Diagnosis Open
Background This Consensus Workshop dealt with diagnostic methodologies in the context of surveillance, screening, assessment of stage and grade, prognosis, monitoring and prediction of periodontal status. Several elements provided the impe…
View article: Dental and oral health assessments in the German National Cohort (NAKO)
Dental and oral health assessments in the German National Cohort (NAKO) Open
Background Despite considerable improvements in oral health in recent decades, caries and periodontitis are still widespread, ranking among the most prevalent diseases worldwide and requiring future research. The German National Cohort (NA…
View article: Population Proteomics: A Tool to Gain Insights Into the Inflamed Periodontium
Population Proteomics: A Tool to Gain Insights Into the Inflamed Periodontium Open
Periodontitis, characterized by inflammatory loss of tooth‐supporting tissues associated with biofilm, is among the most prevalent chronic diseases globally, affecting approximately 50% of the adult population to a moderate extent and case…
View article: Correction: The role of the oral microbiota in the causal effect of adjunctive antibiotics on clinical outcomes in stage III–IV periodontitis patients
Correction: The role of the oral microbiota in the causal effect of adjunctive antibiotics on clinical outcomes in stage III–IV periodontitis patients Open
View article: A Methodological Study on Microbial In Vivo Sampling Methods of Root Canal Microbiota for Next-Generation Gene Sequencing Analysis
A Methodological Study on Microbial In Vivo Sampling Methods of Root Canal Microbiota for Next-Generation Gene Sequencing Analysis Open
Paper point and endodontic instrument sampling generate valid specimens for 16S rDNA community profiling. Endodontic instrument sampling is easier to execute and, therefore, could be the technique of choice.
View article: The role of the oral microbiota in the causal effect of adjunctive antibiotics on clinical outcomes in stage III–IV periodontitis patients
The role of the oral microbiota in the causal effect of adjunctive antibiotics on clinical outcomes in stage III–IV periodontitis patients Open
View article: Long‐term changes in the subgingival microbiota in patients with stage <scp>III–IV</scp> periodontitis treated by mechanical therapy and adjunctive systemic antibiotics: A secondary analysis of a randomized controlled trial
Long‐term changes in the subgingival microbiota in patients with stage <span>III–IV</span> periodontitis treated by mechanical therapy and adjunctive systemic antibiotics: A secondary analysis of a randomized controlled trial Open
Aim To explore whether adjunctive antibiotics can relevantly influence long‐term microbiota changes in stage III–IV periodontitis patients. Materials and Methods This is a secondary analysis of a randomized clinical trial on periodontal th…
View article: Effect of interleukin‐17 on periodontitis development: An instrumental variable analysis
Effect of interleukin‐17 on periodontitis development: An instrumental variable analysis Open
Background Circulating levels of interleukin‐17 (IL‐17) are associated with the presence and severity of periodontitis. However, whether IL‐17 is causal for disease development is unknown. We investigated the effect of genetically proxied …
View article: Ex vivo assessment of the buccal and oral bone by CBCT
Ex vivo assessment of the buccal and oral bone by CBCT Open
View article: Nitrate‐rich diet alters the composition of the oral microbiota in periodontal recall patients
Nitrate‐rich diet alters the composition of the oral microbiota in periodontal recall patients Open
Background This follow‐up study evaluated microbiome changes in periodontal recall patients after consuming a nitrate‐rich diet that led to a marked decrease of gingival inflammation. Methods Subgingival microbial samples of 37 patients su…
View article: A systematic review on bacterial community changes after periodontal therapy with and without systemic antibiotics: An analysis with a wider lens
A systematic review on bacterial community changes after periodontal therapy with and without systemic antibiotics: An analysis with a wider lens Open
Background This systematic review aimed to provide a comprehensive view on microbial community shifts after periodontal therapy with and without systemic antibiotics, conducted in randomized controlled trials (RCTs). Methods Search functio…
View article: Significant Short-Term Shifts in the Microbiomes of Smokers With Periodontitis After Periodontal Therapy With Amoxicillin & Metronidazole as Revealed by 16S rDNA Amplicon Next Generation Sequencing
Significant Short-Term Shifts in the Microbiomes of Smokers With Periodontitis After Periodontal Therapy With Amoxicillin & Metronidazole as Revealed by 16S rDNA Amplicon Next Generation Sequencing Open
The aim of this follow-up study was, to compare the effects of mechanical periodontal therapy with or without adjunctive amoxicillin and metronidazole on the subgingival microbiome of smokers with periodontitis using 16S rDNA amplicon next…
View article: Design und Qualitätskontrolle der zahnmedizinischen Untersuchung in der NAKO Gesundheitsstudie
Design und Qualitätskontrolle der zahnmedizinischen Untersuchung in der NAKO Gesundheitsstudie Open
View article: Periodontal Health and Use of Oral Health Services: A Comparison of Germans and Two Migrant Groups
Periodontal Health and Use of Oral Health Services: A Comparison of Germans and Two Migrant Groups Open
A cross-sectional study was performed with 251 individuals, consisting of 127 Germans, 68 migrants from Turkey, and 56 resettlers (migrants from the former Soviet Union with German ancestors) to compare periodontal health status, with a sp…
View article: No differences in microbiome changes between anti‐adhesive and antibacterial ingredients in toothpastes during periodontal therapy
No differences in microbiome changes between anti‐adhesive and antibacterial ingredients in toothpastes during periodontal therapy Open
Aim This subgroup analysis of a 12‐week randomized, double‐blind, and two‐center trial aimed to evaluate whether two different toothpaste formulations can differentially modulate the dental microbiome. Material and Methods Forty one mild t…
View article: Do we treat our patients or rather periodontal microbes with adjunctive antibiotics in periodontal therapy? A 16S rDNA microbial community analysis
Do we treat our patients or rather periodontal microbes with adjunctive antibiotics in periodontal therapy? A 16S rDNA microbial community analysis Open
Empiric antibiotics are often used in combination with mechanical debridement to treat patients suffering from periodontitis and to eliminate disease-associated pathogens. Until now, only a few next generation sequencing 16S rDNA amplicon …
View article: Clustering of Subgingival Microbiota Reveals Microbial Disease Ecotypes Associated with Clinical Stages of Periodontitis in a Cross-Sectional Study
Clustering of Subgingival Microbiota Reveals Microbial Disease Ecotypes Associated with Clinical Stages of Periodontitis in a Cross-Sectional Study Open
Periodontitis is characterized by chronic inflammation associated with alteration of the oral microbiota. In contrast to previous microbiome studies focusing a priori on comparison between extreme phenotypes, our study analyzed a ra…
View article: Pocket depth and bleeding on probing and their associations with dental, lifestyle, socioeconomic and blood variables: a cross-sectional, multicenter feasibility study of the German National Cohort
Pocket depth and bleeding on probing and their associations with dental, lifestyle, socioeconomic and blood variables: a cross-sectional, multicenter feasibility study of the German National Cohort Open