Daniel Hägg
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View article: Treatment with the Bifidobacterium longum Strain DSM 32947 Increases Bone Mineral Density in Female Mice
Treatment with the Bifidobacterium longum Strain DSM 32947 Increases Bone Mineral Density in Female Mice Open
Previous studies have shown that the gut microbiota regulates bone mass and that certain strains of Bifidobacterium longum prevent bone loss in ovariectomized (ovx) mice. A novel strain of Bifidobacterium longum ( B. longum subsp. longum D…
View article: Body weight reduction by increased weight loading in mice is associated with sensory signaling in the dorsal horn of the lumbar spinal cord
Body weight reduction by increased weight loading in mice is associated with sensory signaling in the dorsal horn of the lumbar spinal cord Open
Previously, we demonstrated that increased weight loading suppresses body weight and food intake in rodents. Our earlier studies suggested that the hind limbs sense this increased load and transmit signals to the Nucleus of the Solitary Tr…
View article: Loading Enhances Glucose Uptake in Muscles, Bones, and Bone Marrow of Lower Extremities in Humans
Loading Enhances Glucose Uptake in Muscles, Bones, and Bone Marrow of Lower Extremities in Humans Open
Context Increased standing time has been associated with improved health, but the underlying mechanism is unclear. Objectives We herein investigate if increased weight loading increases energy demand and thereby glucose uptake (GU) locally…
View article: Reduction of body weight by increased loading is associated with activation of norepinephrine neurones in the medial nucleus of the solitary tract
Reduction of body weight by increased loading is associated with activation of norepinephrine neurones in the medial nucleus of the solitary tract Open
We previously provided evidence supporting the existence of a novel leptin‐independent body weight homeostat (“the gravitostat”) that senses body weight and then initiates a homeostatic feed‐back regulation of body weight. We, herein, hypo…
View article: The dual hypothesis of homeostatic body weight regulation, including gravity-dependent and leptin-dependent actions
The dual hypothesis of homeostatic body weight regulation, including gravity-dependent and leptin-dependent actions Open
Body weight is tightly regulated when outside the normal range. It has been proposed that there are individual-specific lower and upper intervention points for when the homeostatic regulation of body weight is initiated. The nature of the …
View article: A Body Weight Sensor Regulates Prepubertal Growth via the Somatotropic Axis in Male Rats
A Body Weight Sensor Regulates Prepubertal Growth via the Somatotropic Axis in Male Rats Open
In healthy conditions, prepubertal growth follows an individual specific growth channel. Growth hormone (GH) is undoubtedly the major regulator of growth. However, the homeostatic regulation to maintain the individual specific growth chann…
View article: Increased weight loading reduces body weight and body fat in obese subjects – A proof of concept randomized clinical trial
Increased weight loading reduces body weight and body fat in obese subjects – A proof of concept randomized clinical trial Open
Funded by Jane and Dan Olsson (JADO) Foundation, the Torsten Söderberg Foundation, The Knut and Alice Wallenberg's Foundation and the Novo Nordisk Foundation.
View article: Interactions Between the Gravitostat and the Fibroblast Growth Factor System for the Regulation of Body Weight
Interactions Between the Gravitostat and the Fibroblast Growth Factor System for the Regulation of Body Weight Open
Both fibroblast growth factors (FGFs), by binding to FGF receptors (FGFRs), and activation of the gravitostat, by artificial loading, decrease the body weight (BW). Previous studies demonstrate that both the FGF system and loading have the…
View article: The Gravitostat Regulates Fat Mass in Obese Male Mice While Leptin Regulates Fat Mass in Lean Male Mice
The Gravitostat Regulates Fat Mass in Obese Male Mice While Leptin Regulates Fat Mass in Lean Male Mice Open
Leptin has been the only known homeostatic regulator of fat mass, but we recently found evidence for a second one, named the gravitostat. In the current study, we compared the effects of leptin and increased loading (gravitostat stimulatio…
View article: Body weight homeostat that regulates fat mass independently of leptin in rats and mice
Body weight homeostat that regulates fat mass independently of leptin in rats and mice Open
Significance The only known homeostatic regulator of fat mass is the leptin system. We hypothesized that there is a second homeostat regulating body weight with an impact on fat mass. In this study we have added and removed weight loads fr…
View article: In Vivo Chondrogenesis in 3D Bioprinted Human Cell-laden Hydrogel Constructs
In Vivo Chondrogenesis in 3D Bioprinted Human Cell-laden Hydrogel Constructs Open
Background: The three-dimensional (3D) bioprinting technology allows creation of 3D constructs in a layer-by-layer fashion utilizing biologically relevant materials such as biopolymers and cells. The aim of this study is to investigate the…