Daniel Hofius
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View article: Autophagy and Bacterial infections
Autophagy and Bacterial infections Open
Autophagy is an evolutionarily conserved cellular process that is prominent during bacterial infections. In this review article, we discuss how direct pathogen clearance via xenophagy and regulation of inflammatory products represent dual …
View article: Salicylic acid and the viral virulence factor 2b regulate the divergent roles of autophagy during cucumber mosaic virus infection
Salicylic acid and the viral virulence factor 2b regulate the divergent roles of autophagy during cucumber mosaic virus infection Open
Macroautophagy/autophagy is a conserved intracellular degradation pathway that has recently emerged as an integral part of plant responses to virus infection. The known mechanisms of autophagy range from the selective degradation of viral …
View article: Turnip crinkle virus targets host ATG8 proteins to attenuate antiviral autophagy
Turnip crinkle virus targets host ATG8 proteins to attenuate antiviral autophagy Open
SUMMARY Autophagy has emerged as a central player in plant virus disease and resistance. In this study we have addressed the potential roles of autophagy in Turnip crinkle virus (TCV) infection. We found that autophagy attenuates disease s…
View article: A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component Open
Beyond its role in cellular homeostasis, autophagy plays anti- and pro-microbial roles in host-microbe interactions, both in animals and plants. One prominent role of anti-microbial autophagy is to degrade intracellular pathogens or microb…
View article: Polycomb Repressive Complex 2 and KRYPTONITE regulate pathogen-induced programmed cell death in Arabidopsis
Polycomb Repressive Complex 2 and KRYPTONITE regulate pathogen-induced programmed cell death in Arabidopsis Open
The Polycomb Repressive Complex 2 (PRC2) is well-known for its role in controlling developmental transitions by suppressing the premature expression of key developmental regulators. Previous work revealed that PRC2 also controls the onset …
View article: Salicylic acid and the viral virulence factor 2b regulate the divergent roles of autophagy during cucumber mosaic virus infection
Salicylic acid and the viral virulence factor 2b regulate the divergent roles of autophagy during cucumber mosaic virus infection Open
Macroautophagy/autophagy is a conserved intracellular degradation pathway that has recently emerged as an integral part of plant responses to virus infection. The known mechanisms of autophagy range from the selective degradation of viral …
View article: Retromer Contributes to Immunity-Associated Cell Death in Arabidopsis
Retromer Contributes to Immunity-Associated Cell Death in Arabidopsis Open
Membrane trafficking is required during plant immune responses, but its contribution to the hypersensitive response (HR), a form of programmed cell death (PCD) associated with effector-triggered immunity, is not well understood. HR is indu…
View article: Arabidopsis RING‐type E3 ubiquitin ligase XBAT35.2 promotes proteasome‐dependent degradation of ACD11 to attenuate abiotic stress tolerance
Arabidopsis RING‐type E3 ubiquitin ligase XBAT35.2 promotes proteasome‐dependent degradation of ACD11 to attenuate abiotic stress tolerance Open
SUMMARY Plants employ multiple mechanisms to cope with a constantly changing and challenging environment, including using the ubiquitin proteasome system (UPS) to alter their proteome to assist in initiating, modulating and terminating res…
View article: Autophagic degradation of the Cucumber mosaic virus virulence factor 2b balances antiviral RNA silencing with proviral plant fitness and virus seed transmission
Autophagic degradation of the Cucumber mosaic virus virulence factor 2b balances antiviral RNA silencing with proviral plant fitness and virus seed transmission Open
Autophagy is a conserved intracellular degradation pathway that has recently emerged as an integral part of plant responses to virus infection. The elucidated mechanisms of autophagy range from the selective degradation of viral components…
View article: Autophagy–virus interplay in plants: from antiviral recognition to proviral manipulation
Autophagy–virus interplay in plants: from antiviral recognition to proviral manipulation Open
Summary Autophagy is a conserved self‐cleaning and renewal system required for cellular homeostasis and stress tolerance. Autophagic processes are also implicated in the response to ‘non‐self’ such as viral pathogens, yet the functions and…
View article: Anti- and pro-microbial roles of autophagy in plant-bacteria interactions
Anti- and pro-microbial roles of autophagy in plant-bacteria interactions Open
Macroautophagy/autophagy and the ubiquitin-proteasome system (UPS) are major proteolytic pathways that are increasingly recognized as battlegrounds during host-microbe interactions in eukaryotes. In plants, the UPS has emerged as central c…
View article: Corrigendum: Autophagy-related approaches for improving nutrient use efficiency and crop yield protection
Corrigendum: Autophagy-related approaches for improving nutrient use efficiency and crop yield protection Open
Correction : 10.1093/jxb/ery113
View article: Bacteria Exploit Autophagy for Proteasome Degradation and Enhanced Virulence in Plants
Bacteria Exploit Autophagy for Proteasome Degradation and Enhanced Virulence in Plants Open
Autophagy and the ubiquitin-proteasome system (UPS) are two major protein degradation pathways implicated in the response to microbial infections in eukaryotes. In animals, the contribution of autophagy and the UPS to antibacterial immunit…
View article: Autophagy-related approaches for improving nutrient use efficiency and crop yield protection
Autophagy-related approaches for improving nutrient use efficiency and crop yield protection Open
Autophagy is a eukaryotic catabolic pathway essential for growth and development. In plants, it is activated in response to environmental cues or developmental stimuli. However, in contrast to other eukaryotic systems, we know relatively l…
View article: Transcriptional stimulation of rate-limiting components of the autophagic pathway improves plant fitness
Transcriptional stimulation of rate-limiting components of the autophagic pathway improves plant fitness Open
Autophagy is a major catabolic process whereby autophagosomes deliver cytoplasmic content to the lytic compartment for recycling. Autophagosome formation requires two ubiquitin-like systems conjugating Atg12 with Atg5, and Atg8 with lipid …
View article: Turnip Mosaic Virus Counteracts Selective Autophagy of the Viral Silencing Suppressor HCpro
Turnip Mosaic Virus Counteracts Selective Autophagy of the Viral Silencing Suppressor HCpro Open
Autophagy is a conserved intracellular degradation pathway and has emerged as a key mechanism of antiviral immunity in metazoans, including the selective elimination of viral components. In turn, some animal viruses are able to escape and …
View article: NBR1-mediated antiviral xenophagy in plant immunity
NBR1-mediated antiviral xenophagy in plant immunity Open
Macroautophagy/autophagy intersects with metazoan virus infections in highly complex and multifaceted ways. Autophagy mechanisms are part of antiviral immunity, but can be manipulated by several viruses to the benefit of infection. In plan…
View article: The RING-Type E3 Ligase XBAT35.2 Is Involved in Cell Death Induction and Pathogen Response
The RING-Type E3 Ligase XBAT35.2 Is Involved in Cell Death Induction and Pathogen Response Open
XBAT35 belongs to a subfamily of Arabidopsis (Arabidopsis thaliana) RING-type E3s that are similar in domain architecture to the rice (Oryza sativa) XA21 Binding Protein3, a defense protein. The XBAT35 transcript undergoes alternative spli…
View article: Selective autophagy limits cauliflower mosaic virus infection by NBR1-mediated targeting of viral capsid protein and particles
Selective autophagy limits cauliflower mosaic virus infection by NBR1-mediated targeting of viral capsid protein and particles Open
Significance Autophagy contributes to innate immune responses in metazoans by targeted elimination of intracellular pathogens, including viruses, in a process termed “xenophagy.” Whether autophagy has a similar role in plant immunity is un…
View article: Salicylic acid interferes with GFP fluorescence in vivo
Salicylic acid interferes with GFP fluorescence in vivo Open
Fluorescent proteins have become essential tools for cell biologists. They are routinely used by plant biologists for protein and promoter fusions to infer protein localization, tissue-specific expression and protein abundance. When studyi…