Seung Pyo Hong
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View article: Deciphering gut microbiome patterns from host preferences and microbial interactions in healthy Korean individuals
Deciphering gut microbiome patterns from host preferences and microbial interactions in healthy Korean individuals Open
This study reveals intricate structures and interactions within microbial communities, offering insights into the gut microbiome ecology and guiding health enhancement strategies.
View article: Functional Characterization and Heterogeneity Analysis of Ribosomal Proteins in Mouse Preimplantation Embryos
Functional Characterization and Heterogeneity Analysis of Ribosomal Proteins in Mouse Preimplantation Embryos Open
Translational control is important during the mammalian preimplantation phase, when maternal RNAs and proteins are degraded and de novo synthesis of RNAs and proteins increases. Proteins are synthesized in ribosomes, which are assembled fr…
View article: Cushing’s Syndrome in Adenocarcinoma of Lung Responding to Osilodrostat
Cushing’s Syndrome in Adenocarcinoma of Lung Responding to Osilodrostat Open
Cushing’s syndrome (CS), secondary to paraneoplastic syndrome, is more commonly seen in small cell lung cancer but never before reported in epidermal growth factor receptor-mutated adenocarcinoma of the lung. Here, we present a case of a p…
View article: Impaired Blastocyst Formation in Lnx2-Knockdown Mouse Embryos
Impaired Blastocyst Formation in Lnx2-Knockdown Mouse Embryos Open
Ligand of Numb-protein X 2 (LNX2) is an E3 ubiquitin ligase that is known to regulate Notch signaling by participating in NUMB protein degradation. Notch signaling is important for differentiation and proliferation in mammals, and plays a …
View article: 519 Meta-analysis on immunotherapy-related hyperprogressive disease (HPD) incidence across tumor types and HPD definitions
519 Meta-analysis on immunotherapy-related hyperprogressive disease (HPD) incidence across tumor types and HPD definitions Open
Background While reported in other types of systemic therapy as well, evidence for hyperprogressive disease (HPD) following onset of immunotherapy has increased in the past decade. Despite such growing evidence, the lack of a consensual de…
View article: Acceptor dependent catalytic properties of GH57 4-α-glucanotransferase from Pyrococcus sp. ST04
Acceptor dependent catalytic properties of GH57 4-α-glucanotransferase from Pyrococcus sp. ST04 Open
The 4-α-glucanotransferase (4-α-GTase or amylomaltase) is an essential enzyme in maltodextrin metabolism. Generally, most bacterial 4-α-GTase is classified into glycoside hydrolase (GH) family 77. However, hyperthermophiles have unique 4-α…
View article: Effects of Brain-Timing Training on Reading Abilities : A Retrospective Comparative Study
Effects of Brain-Timing Training on Reading Abilities : A Retrospective Comparative Study Open
목적 : 본 연구는 두뇌타이밍 능력이 낮은 아동을 대상으로 상호작용식 메트로놈(Interactive Metromome; IM)을 이용한 두뇌타이밍 훈련을 적용한 후 읽기 능력에 미치는 효과를 파악하고자 하였다. 연구방법 : 2019년∼2021년에 아동발달연구소에서 IM 훈련을 시행한 아동 중 타이밍 능력이 자신의 연 령 평균보다 낮은 아동 8명의 자료를 수집하여 검사 전-검사 후의 변화를 비교하였다. 두뇌타이밍 훈련 은 주당…
View article: Scanning Deposition Method for Large-Area Diamond Film Synthesis Using Multiple Microwave Plasma Sources
Scanning Deposition Method for Large-Area Diamond Film Synthesis Using Multiple Microwave Plasma Sources Open
The demand for synthetic diamonds and research on their use in next-generation semiconductor devices have recently increased. Microwave plasma chemical vapor deposition (MPCVD) is considered one of the most promising techniques for the mas…
View article: Role of mass spectrometry-based serum proteomics signatures in predicting clinical outcomes and toxicity in patients with cancer treated with immunotherapy
Role of mass spectrometry-based serum proteomics signatures in predicting clinical outcomes and toxicity in patients with cancer treated with immunotherapy Open
Immunotherapy has fundamentally changed the landscape of cancer treatment. However, only a subset of patients respond to immunotherapy, and a significant portion experience immune-related adverse events (irAEs). In addition, the predictive…
View article: Effect of Saengshik Supplementation on the Gut Microbial Composition of Healthy Korean Adults: A Single-Group Pilot Study
Effect of Saengshik Supplementation on the Gut Microbial Composition of Healthy Korean Adults: A Single-Group Pilot Study Open
Saengshik is a type of meal-replacement product or dietary supplement comprising an uncooked and dried plant-based food mixture with various health-promoting properties, such as antidiabetic, anti-dyslipidemic, antioxidant, and anticancer …
View article: Diagnostic and prognostic potential of the oral and gut microbiome for lung adenocarcinoma
Diagnostic and prognostic potential of the oral and gut microbiome for lung adenocarcinoma Open
Dear Editor, Lung cancer is one of the most common cancers.1 Although its primary risk factor is smoking,2 15–20% and >50% of male and female lung cancer patients, respectively, are nonsmokers,3, 4 which indicates the involvement of other …
View article: Gut Microbiome Structure and Association with Host Factors in a Korean Population
Gut Microbiome Structure and Association with Host Factors in a Korean Population Open
Comparing the gut microbiomes of healthy controls and disease patients showed that the composition of the gut microbiome is associated with various host health conditions. The gut microbiome in healthy Western populations is well character…
View article: Exploring real-world concordance of tissue mutation burden (TMB) from blood and tissue in patients with solid tumors
Exploring real-world concordance of tissue mutation burden (TMB) from blood and tissue in patients with solid tumors Open
Purpose Tumor mutational burden (TMB) is an approved biomarker for immunotherapy in metastatic cancer patients. While initially measured from tissue (tTMB), TMB derived from circulating tumor DNA (ctDNA) - also known as blood TMB (bTMB) - …
View article: Propolis Suppresses UV-Induced Photoaging in Human Skin through Directly Targeting Phosphoinositide 3-Kinase
Propolis Suppresses UV-Induced Photoaging in Human Skin through Directly Targeting Phosphoinositide 3-Kinase Open
Propolis is a resinous substance generated by bees using materials from various plant sources. It has been known to exhibit diverse bioactivities including anti-oxidative, anti-microbial, anti-inflammatory, and anti-cancer effects. However…
View article: <i>Mir214-3p</i> and <i>Hnf4a/Hnf4α</i> reciprocally regulate <i>Ulk1</i> expression and autophagy in nonalcoholic hepatic steatosis
<i>Mir214-3p</i> and <i>Hnf4a/Hnf4α</i> reciprocally regulate <i>Ulk1</i> expression and autophagy in nonalcoholic hepatic steatosis Open
Macroautophagy/autophagy, a self-degradative process, regulates metabolic homeostasis in response to various stress conditions and is a therapeutic target for nonalcoholic fatty liver disease. We found that autophagic activity was inhibite…
View article: Piceatannol reduces resistance to statins in hypercholesterolemia by reducing PCSK9 expression through p300 acetyltransferase inhibition
Piceatannol reduces resistance to statins in hypercholesterolemia by reducing PCSK9 expression through p300 acetyltransferase inhibition Open
The purpose of this study was to investigate the role of piceatannol (PT) in statin (rosuvastatin and simvastatin) resistance and tolerance and its association with PCSK9 expression via its p300 inhibitory (p300i) activity. An in vitro stu…
View article: Molecular Docking and Kinetic Studies of the A226N Mutant of <i>Deinococcus geothermalis</i> Amylosucrase with Enhanced Transglucosylation Activity
Molecular Docking and Kinetic Studies of the A226N Mutant of <i>Deinococcus geothermalis</i> Amylosucrase with Enhanced Transglucosylation Activity Open
Amylosucrase (ASase, E.C. 2.4.1.4) is capable of efficient glucose transfer from sucrose, acting as the sole donor molecule, to various functional acceptor compounds, such as polyphenols and flavonoids. An ASase variant from Deinococcus ge…
View article: Changes in microbiome and metabolomic profiles of fecal samples stored with stabilizing solution at room temperature: a pilot study
Changes in microbiome and metabolomic profiles of fecal samples stored with stabilizing solution at room temperature: a pilot study Open
The gut microbiome is related to various host health conditions through metabolites produced by microbiota. Investigating their relationships involves association analysis of the population-level microbiome and metabolome data, which requi…
View article: Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin
Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin Open
Quercetin is a naturally occurring polyphenol present in various fruits and vegetables. The bioactive properties of quercetin include anti-oxidative, anti-cancer, anti-inflammatory, and anti-diabetic effects. However, the effect of quercet…
View article: Changes in microbiome and metabolomic profiles of fecal samples stored with stabilizing solution at room temperature
Changes in microbiome and metabolomic profiles of fecal samples stored with stabilizing solution at room temperature Open
Metabolite profiles of samples stored at room temperature. Fecal samples from three individuals were stored in non-stabilization condition and in OMNIgene.GUT metagenome stabilization solution up to 21 days. Their metabolites were profiled…
View article: Changes in microbiome and metabolomic profiles of fecal samples stored with stabilizing solution at room temperature
Changes in microbiome and metabolomic profiles of fecal samples stored with stabilizing solution at room temperature Open
Metabolite profiles of samples stored at room temperature. Fecal samples from three individuals were stored in non-stabilization condition and in OMNIgene.GUT metagenome stabilization solution up to 21 days. Their metabolites were profiled…
View article: Two-Dimensional NbS<sub>2</sub> Gas Sensors for Selective and Reversible NO<sub>2</sub> Detection at Room Temperature
Two-Dimensional NbS<sub>2</sub> Gas Sensors for Selective and Reversible NO<sub>2</sub> Detection at Room Temperature Open
Transition metal dichalcogenides (TMDs) have attracted enormous attention in diverse research fields. Especially, gas sensors are considered in a promising application exploiting TMDs. However, the studies are confined to only major TMDs s…
View article: Engineering Clostridial Aldehyde/Alcohol Dehydrogenase for Selective Butanol Production
Engineering Clostridial Aldehyde/Alcohol Dehydrogenase for Selective Butanol Production Open
Renewable biofuel represents one of the answers to solving the energy crisis and climate change problems. Butanol produced naturally by clostridia has superior liquid fuel characteristics and thus has the potential to replace gasoline. Due…