Daniël Hoyer
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View article: 5-Hydroxytryptamine receptors in GtoPdb v.2025.3
5-Hydroxytryptamine receptors in GtoPdb v.2025.3 Open
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [201] and subsequently revised [183]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. …
View article: The WiserAD Trial: Protocol for the Pragmatic, Randomised Controlled Trial of a Structured Online Support Intervention to Inform and Assist Antidepressant Deprescribing in Primary Care. (Preprint)
The WiserAD Trial: Protocol for the Pragmatic, Randomised Controlled Trial of a Structured Online Support Intervention to Inform and Assist Antidepressant Deprescribing in Primary Care. (Preprint) Open
BACKGROUND The use of antidepressant medications is increasing globally. However, despite their obvious benefits, there is reason to believe that ongoing use of these medications is often not properly monitored or deprescribed when a pers…
View article: Psychedelics, entactogens and psychoplastogens for depression and related disorders
Psychedelics, entactogens and psychoplastogens for depression and related disorders Open
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N , N ‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psyc…
View article: 5-Hydroxytryptamine receptors in GtoPdb v.2025.1
5-Hydroxytryptamine receptors in GtoPdb v.2025.1 Open
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [200] and subsequently revised [182]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. …
View article: Secondary sclerosing cholangitis in patients suffering cardiogenic shock
Secondary sclerosing cholangitis in patients suffering cardiogenic shock Open
Aims Cardiogenic shock (CS) patients suffer from severe organ hypoperfusion, yet the incidence of secondary sclerosing cholangitis in critically ill patients (SSC‐CIP) in CS is poorly described. Given the limited evidence and severity of t…
View article: Cliopatria - A geospatial database of world-wide political entities from 3400BCE to 2024CE
Cliopatria - A geospatial database of world-wide political entities from 3400BCE to 2024CE Open
The scientific understanding of the complex dynamics of global history – from the rise and spread of states to their declines and falls, from their peaceful interactions with economic or diplomatic exchanges to violent confrontations – req…
View article: The distribution of Hypocretin/Orexin receptor mRNA in the mouse and human brain
The distribution of Hypocretin/Orexin receptor mRNA in the mouse and human brain Open
Hypocretin (Hcrtr, HCRTR) / orexin (OX) receptors modulate a range of neurobiological functions and are drug targets for several disorders. Mapping the distribution of receptors in the brain can inform their function and guide targeting of…
View article: International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology
International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology Open
The orexin system consists of the peptide transmitters orexin-A and -B and the G protein-coupled orexin receptors OX1 and OX2 Orexin receptors are capable of coupling to all four families of heterotrimeric G proteins, and there are also ot…
View article: International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function Open
5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and function reflects the important role 5-HT receptors play in physiologic and path…
View article: On serotonin, psychedelics, entactogens and psychoplastogens in depression, anxiety, post-traumatic stress, and related disorders.
On serotonin, psychedelics, entactogens and psychoplastogens in depression, anxiety, post-traumatic stress, and related disorders. Open
There is controversy about a causal role of serotonin (5-HT) in depression, some arguing that there is no proof for impaired brain 5-HT function in depressed patients. Major depressive disorder comes with multiple endophenotypes; not surpr…
View article: On the kinetic features of orexin receptor antagonists at orexin receptors, transduction systems and receptor binding
On the kinetic features of orexin receptor antagonists at orexin receptors, transduction systems and receptor binding Open
Orexin receptor antagonists are on the market or under development for the treatment of insomnia and a number of other neuropsychiatric disorders. Currently, suvorexant, lemborexant and daridorexant, three dual orexin receptor antagonists …
View article: A contemporary training concept in critical care cardiology
A contemporary training concept in critical care cardiology Open
Critical care cardiology (CCC) in the modern era is shaped by a multitude of innovative treatment options and an increasingly complex, ageing patient population. Generating high-quality evidence for novel interventions and devices in an in…
View article: A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli
A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli Open
Treatment of multidrug-resistant Gram-negative bacterial pathogens represents a critical clinical need. Here, we report a novel γ-lactam pyrazolidinone that targets penicillin-binding proteins (PBPs) and incorporates a siderophore moiety t…
View article: The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors Open
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 600…
View article: Effectiveness of conduction system pacing for cardiac resynchronization therapy: A systematic review and network meta‐analysis
Effectiveness of conduction system pacing for cardiac resynchronization therapy: A systematic review and network meta‐analysis Open
Introduction Cardiac resynchronization therapy (CRT) with biventricular pacing (BiV‐CRT) is ineffective in approximately one‐third of patients. CRT with Conduction system pacing (CSP‐CRT) may achieve greater synchronization. We aimed to as…
View article: Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease Open
Sleep is essential for human well-being, yet the quality and quantity of sleep reduce as age advances. Older persons (>65 years old) are more at risk of disorders accompanied and/or exacerbated by poor sleep. Furthermore, evidence supports…
View article: Safety and efficacy of renal sympathetic denervation: a 9-year long-term follow-up of 24-hour ambulatory blood pressure measurements
Safety and efficacy of renal sympathetic denervation: a 9-year long-term follow-up of 24-hour ambulatory blood pressure measurements Open
Background Renal sympathetic denervation (RDN) has been shown to lower arterial blood pressure both in the presence and in the absence of antihypertensive medication in an observation period of up to 3 years. However, long-term results bey…
View article: Somatostatin receptors in GtoPdb v.2023.1
Somatostatin receptors in GtoPdb v.2023.1 Open
Somatostatin (somatotropin release inhibiting factor) is an abundant neuropeptide, which acts on five subtypes of somatostatin receptor (SST1-SST5; nomenclature as agreed by the NC-IUPHAR Subcommittee on Somatostatin Receptors [98]). Activ…
View article: 5-Hydroxytryptamine receptors in GtoPdb v.2023.1
5-Hydroxytryptamine receptors in GtoPdb v.2023.1 Open
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [198] and subsequently revised [180]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. …
View article: Orexin receptors in GtoPdb v.2023.1
Orexin receptors in GtoPdb v.2023.1 Open
Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [43]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common pre…
View article: Default Mode Network Modulation by Psychedelics: A Systematic Review
Default Mode Network Modulation by Psychedelics: A Systematic Review Open
Psychedelics are a unique class of drug that commonly produce vivid hallucinations as well as profound psychological and mystical experiences. A grouping of interconnected brain regions characterized by increased temporal coherence at rest…
View article: Introduction to Special Issue: Leading Scholars of the Past Comment on Dawn of Everything
Introduction to Special Issue: Leading Scholars of the Past Comment on Dawn of Everything Open
Critical Reception
View article: Orexin Signaling: A Complex, Multifaceted Process
Orexin Signaling: A Complex, Multifaceted Process Open
The orexin system comprises two G protein-coupled receptors, OX 1 and OX 2 receptors (OX 1 R and OX 2 R, respectively), along with two endogenous agonists cleaved from a common precursor (prepro-orexin), orexin-A (OX-A) and orexin-B (OX-B)…