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View article: Alterations of sensorimotor predictive processes and their electrophysiological signatures in Tourette syndrome
Alterations of sensorimotor predictive processes and their electrophysiological signatures in Tourette syndrome Open
People with Tourette syndrome exhibit excessive motor actions known as tics. An aversive sensation called the premonitory urge often precedes these tics, leading to the conceptualization of Tourette syndrome as a sensorimotor disorder. In …
View article: Alterations of sensorimotor predictive processes and their electrophysiological signatures in Tourette syndrome
Alterations of sensorimotor predictive processes and their electrophysiological signatures in Tourette syndrome Open
People with Tourette syndrome exhibit excessive motor actions known as tics. An aversive sensation called the premonitory urge often precedes these tics, leading to the conceptualization of Tourette syndrome as a sensorimotor disorder. In …
View article: Thalamic deep brain stimulation for tourette syndrome increases cortical beta activity
Thalamic deep brain stimulation for tourette syndrome increases cortical beta activity Open
Thalamic DBS in TS patients modulates beta frequency oscillations presumably important for sensorimotor function and relevant to TS pathophysiology.
View article: Chronic Deep Brain Stimulation of the Human Nucleus Accumbens Region Disrupts the Stability of Intertemporal Preferences
Chronic Deep Brain Stimulation of the Human Nucleus Accumbens Region Disrupts the Stability of Intertemporal Preferences Open
When choosing between rewards that differ in temporal proximity (intertemporal choice), human preferences are typically stable, constituting a clinically relevant transdiagnostic trait. Here we show, in female and male human patients under…
View article: Electrophysiological Correlates of Proactive Control and Binding Processes during Task Switching in Tourette Syndrome
Electrophysiological Correlates of Proactive Control and Binding Processes during Task Switching in Tourette Syndrome Open
The occurrence of tics in Tourette syndrome (TS) has often been linked to impaired cognitive control, but empirical findings are still inconclusive. A recent view proposes that tics may be the result of an abnormally strong interrelation b…
View article: CANNA-TICS: Efficacy and safety of oral treatment with nabiximols in adults with chronic tic disorders – Results of a prospective, multicenter, randomized, double-blind, placebo controlled, phase IIIb superiority study
CANNA-TICS: Efficacy and safety of oral treatment with nabiximols in adults with chronic tic disorders – Results of a prospective, multicenter, randomized, double-blind, placebo controlled, phase IIIb superiority study Open
Preliminary data suggest that cannabis-based medicines might be a promising new treatment for patients with Tourette syndrome (TS)/chronic tic disorders (CTD) resulting in an improvement of tics, comorbidities, and quality of life. This ra…
View article: Internal Capsule/Nucleus Accumbens Deep Brain Stimulation Increases Impulsive Decision Making in Obsessive-Compulsive Disorder
Internal Capsule/Nucleus Accumbens Deep Brain Stimulation Increases Impulsive Decision Making in Obsessive-Compulsive Disorder Open
Our findings provide experimental evidence that ALIC/nucleus accumbens stimulation increases impulsive decision making in obsessive-compulsive disorder. We show that changes in risk adjustment depend on the location of stimulation volumes …
View article: Predictors of short-term impulsive and compulsive behaviour after subthalamic stimulation in Parkinson disease
Predictors of short-term impulsive and compulsive behaviour after subthalamic stimulation in Parkinson disease Open
Background The effects of subthalamic stimulation (subthalamic nucleus-deep brain stimulation, STN-DBS) on impulsive and compulsive behaviours (ICB) in Parkinson’s disease (PD) are understudied. Objective To investigate clinical predictors…
View article: A functional network target for tic reduction during thalamic stimulation for Tourette Syndrome
A functional network target for tic reduction during thalamic stimulation for Tourette Syndrome Open
Background Deep brain stimulation (DBS) of the medial thalamus is an evolving therapy for severe, treatment-refractory Tourette syndrome (TS). It remains unanswered which functionally connected networks need to be modulated to obtain optim…
View article: Thalamic deep brain stimulation for Tourette Syndrome: A naturalistic trial with brief randomized, double-blinded sham-controlled periods
Thalamic deep brain stimulation for Tourette Syndrome: A naturalistic trial with brief randomized, double-blinded sham-controlled periods Open
Our results provide evidence that thalamic stimulation is effective in improving tic severity and overall quality of life. Crucially, the reduction of tic severity was primarily driven by active stimulation. Further research may focus on i…
View article: Temporal discounting in adolescents and adults with Tourette syndrome
Temporal discounting in adolescents and adults with Tourette syndrome Open
Tourette syndrome is a neurodevelopmental disorder associated with hyperactivity in dopaminergic networks. Dopaminergic hyperactivity in the basal ganglia has previously been linked to increased sensitivity to positive reinforcement and in…
View article: Error-Related Activity in Striatal Local Field Potentials and Medial Frontal Cortex: Evidence From Patients With Severe Opioid Abuse Disorder
Error-Related Activity in Striatal Local Field Potentials and Medial Frontal Cortex: Evidence From Patients With Severe Opioid Abuse Disorder Open
For successful goal-directed behavior, a performance monitoring system is essential. It detects behavioral errors and initiates behavioral adaptations to improve performance. Two electrophysiological potentials are known to follow errors i…
View article: Connectivity Patterns of Deep Brain Stimulation Targets in Patients with Gilles de la Tourette Syndrome
Connectivity Patterns of Deep Brain Stimulation Targets in Patients with Gilles de la Tourette Syndrome Open
Since 1999, several targets for deep brain stimulation (DBS) in Gilles de la Tourette syndrome (GTS) have emerged showing similar success rates. Studies using different tractography techniques have identified connectivity profiles associat…
View article: Chronic deep brain stimulation of the human nucleus accumbens region disrupts the stability of inter-temporal preferences
Chronic deep brain stimulation of the human nucleus accumbens region disrupts the stability of inter-temporal preferences Open
When choosing between rewards that differ in temporal proximity (inter-temporal choice), human preferences are typically stable, constituting a clinically-relevant transdiagnostic trait. Here we show in patients undergoing deep brain stimu…
View article: A brief demonstration of frontostriatal connectivity in OCD patients with intracranial electrodes
A brief demonstration of frontostriatal connectivity in OCD patients with intracranial electrodes Open
Closed-loop neuromodulation is presumed to be the logical evolution for improving the effectiveness of deep brain stimulation (DBS) treatment protocols (Widge et al., 2018). Identifying symptom-relevant biomarkers that provide meaningful f…
View article: Structural connectivity predicts clinical outcomes of deep brain stimulation for Tourette syndrome
Structural connectivity predicts clinical outcomes of deep brain stimulation for Tourette syndrome Open
Deep brain stimulation may be an effective therapy for select cases of severe, treatment-refractory Tourette syndrome; however, patient responses are variable, and there are no reliable methods to predict clinical outcomes. The objectives …
View article: Modulation of Fibers to Motor Cortex during Thalamic DBS in Tourette Patients Correlates with Tic Reduction
Modulation of Fibers to Motor Cortex during Thalamic DBS in Tourette Patients Correlates with Tic Reduction Open
Probabilistic tractography in Tourette syndrome (TS) patients have shown an alteration in the connectivity of the primary motor cortex and supplementary motor area with the striatum and thalamus, suggesting an abnormal connectivity of the …
View article: Temporal discounting in adolescents and adults with Tourette syndrome
Temporal discounting in adolescents and adults with Tourette syndrome Open
Background Tourette syndrome is a neurodevelopmental disorder with the clinical hallmarks of motor and phonic tics which are associated with hyperactivity in dopaminergic networks. Dopaminergic hyperactivity in the basal ganglia has previo…
View article: Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus
Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus Open
Weight changes are insufficiently understood adverse events of deep brain stimulation. In this context, exploring neural networks of weight control may inform novel treatment strategies for weight-related disorders. In this study, we inves…
View article: Image-based analysis and long-term clinical outcomes of deep brain stimulation for Tourette syndrome: a multisite study
Image-based analysis and long-term clinical outcomes of deep brain stimulation for Tourette syndrome: a multisite study Open
Background Deep brain stimulation (DBS) can be an effective therapy for tics and comorbidities in select cases of severe, treatment-refractory Tourette syndrome (TS). Clinical responses remain variable across patients, which may be attribu…